Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Blast induced neurotrauma"”.
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Epigenetic Mechanisms in Blast-Induced Neurotrauma
Blast-induced neurotrauma (BINT) is a prevalent brain injury within both military and civilian populations due to current engagement in overseas conflict and ongoing terrorist events worldwide. In the early 2000s, 78% of injuries were attributable to an explosive mechanism during overseas …
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Transcranial Administration of Nano Pulse Laser Therapy for Blast Induced Neurotrauma
… as both a prophylactic treatment for a single blast TBI (bTBI) and through multiple applications as a therapeutic for repeated bTBI. In our first aim, male adult Sprague Dawley rats were treated with NPLT 24 hours prior to being subjected to blast TBI. Then the animals were assessed using Beam …
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The Effects of Blast-Induced Neurotrauma on Blood-Brain Barrier Permeability, Cell-Cell Junction Protein Levels and the Role of Peroxynitrite
… challenge for researchers and clinicians alike. Blast-induced Neurotrauma (BINT), often caused by improvised explosive devices (IEDs), is an injury that affects military personnel, however, the increasing threat of worldwide terrorist attacks makes this a concern for all individuals. Many of …
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Experimental study of bubble rupture during shock-fluid interaction
… detonation. There are four distinct types of blast induced neurotrauma (BINT): 1) these caused by supersonic shock waves propagating in the atmosphere (primary), 2) high velocity impact of shrapnel and debris (secondary) 3) acceleration and deceleration of the body and collision with the solid …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
… models of injury and disease. Rodent models of blast induced neurotrauma (BINT) and severe osteoporosis were used to inform the development of 2D and 3D in-vitro models of macrophage/endothelial cell injury and osteogenic differentiation respectively. Keratin biomaterials exhibited some …
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The Post Deployment Lived Experience of U.S. Military Troops after Combat-Related Blast Exposure
Blast-induced neurotrauma (BINT) is a newly emerging re-occurrence of an old combat-related injury in U.S. military troops returning from deployment in Afghanistan and Iraq. BINT is leading to a silent epidemic of symptomatic troops who face barriers to accessing healthcare and suffer debilitating …
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Impaired Behavioral and Pathological Outcomes Following Blast Neurotrauma
Blast-induced neurotrauma (BINT) is a major societal concern due to the complex expression of neuropathological disorders after exposure to blast. Disruptions in neuronal function, proximal in time to the blast exposure, may eventually contribute to the late emergence of the clinical deficits. …
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Investigating Injury Pathology of Blast-induced Polytrauma and Assessing the Therapeutic Role of Hemostatic Nanoparticles after Blast Exposure
… combat related injuries (Ramasamy et al. 2008). Blast overpressure from explosions can cause barotrauma to the lungs and the brain. Blast-induced mild traumatic brain injury has been labeled the "signature wound" of current military conflicts in Iraq and Afghanistan (Snell and Halter 2010). In …
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The Influence of Biomechanics on Acute Spatial and Temporal Pathophysiology Following Blast-Induced Traumatic Brain Injury
Blast-induced traumatic brain injury (bTBI) remains a significant problem among military populations. When an explosion occurs, a high magnitude positive pressure rapidly propagates away from the detonation source. Upon contact, biological tissues throughout the body undergo deformation at high …
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Nonlinear Viscoelastic Wave Propagation in Brain Tissue
… could contribute to mechanism of brain injury in blast loading conditions. The approach consisted of three major steps. In the first step, a viscoelastic constitutive model of bovine brain tissue under finite step-and-hold uniaxial compression with 10 1/s ramp rate and 20 s hold time has been …
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Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular Function, Histopathological and Behavioral Outcomes in Rats
Impact traumatic brain injury (i.e. non-blast TBI) is often associated with reduced cerebral perfusion and impaired cerebrovascular function due, in part, to the generation of reactive oxygen (ROS) and reactive nitrogen species (RNS) (e.g. peroxynitrite, ONOO‾). Although blast TBI (bTBI) also …