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Showing 1 to 20 of 93 for “"Bladder Cancer"”.
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Molecular Classification of Bladder Cancer
Decisions in the treatment of bladder cancer today are based on clinical and pathological risk variables such as tumor stage and tumor grade. The importance of these conventional risk variables is well documented since more than 10 years, and they are used routinely in the clinics. Over the last …
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Molecular Drivers of Bladder Cancer Motility
<p>Bladder cancer (BC) progression is measured by the degree of tumor cell invasion into the bladder wall and dissemination to distant sites. The study of BC cell motility will both enable development of anti-invasion therapeutics to limit progression of early-stage disease and improve our …
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Molecular prognostic factors in bladder cancer
Contains fulltext : mmubn000001_221553789.pdf (Publisher’s version ) (Open Access)
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INVASIVE BLADDER CANCER - Aspects on staging and prognosis
… for the individual patient with invasive bladder cancer is a major clinical problem. Currently, decisions regarding therapy are mainly based on tumour stage and grade, the first of which is notoriously demanding to ascertain. New molecular markers are however proposed to be of prognostic …
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Nuclear receptor co-repressor actions in bladder cancer
… of a range NRs and co-repressors in four bladder cancer cell lines. Nuclear co-repressor 1 (NCoR1) is over-expressed in RT-112 (1.6 fold) and EJ-28 cells (2.6 fold). This correlates with reduced sensitivity to NR ligands in EJ-28 cells. Stable over-expression of NCoR1 in sensitive RT-4 …
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Rational drug combinations to selectively target 9p21-deleted bladder cancer
Precision medicine for cancer therapy has the potential to offer personalized genotype-targeted treatments that exploit the selective dependencies of tumor cells. While several tumor types benefit from the use of targeted therapy, current precision medicine approaches for bladder cancer (BLCA) are …
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Induced Gene Expression In Bladder Cancer: Kindlin-2 And Metallothionein-1x
… by the International Agency on Research in Cancer (IARC). Numerous epidemiological studies have linked arsenite (As+3) and Cd+2 to the development of bladder cancer. Bladder cancer is the second most common genitourinary malignancy in the United States, and one of the first cancers to be …
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Development of non-invasive techniques for bladder cancer diagnosis and therapy
Bladder cancer is among the most common cancers in the UK, responsible for significant patient morbidity. Current techniques for detection suffer from low sensitivity, particularly for early stage disease, therefore new techniques are urgently sought.<br/><br/>Among the suggested techniques to …
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Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
Bladder cancer is the most common malignancy of the urinary tract. However, bladder cancer is a highly heterogenous disease and our understanding of the mechanisms that drive disease progression remain ill-defined. Additionally, a limited range of therapeutics and the dismal prognosis of patients …
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Urinary Volatile Organic Compounds (VOCs) in the Diagnosis of Urothelial Bladder Cancer
Bladder cancer is the seventh most common cancer in the UK (2011), fourth most common cancer in men and thirteenth most common in women. The total annual cost of bladder cancers in the UK was £55.39 million. The cost per patient was £8349 per year, including diagnosing, treating and following up, …
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Interpretable Tumor Localization in Bladder Cancer Histopathology Using Deep Multiple Instance Learning
Deep learning has emerged in cancer histopathology as a tool for predicting clinical and molecular properties of a patient’s disease, thereby connecting slide with function. This concept is especially relevant to bladder cancer, where molecular and histopathologic heterogeneity is known to impact …
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The Applications of Raman Spectroscopy Assisted Urinalysis: Hematuria and Bladder Cancer Detection
… biological solution, for the detection of bladder cancer (BCa) and hematuria. Raman spectroscopy is a rapid, low cost, non-destructive analysis method with wide-ranging applicability due to the holistic data capturing nature of the scanning technique. Each Raman scan can be considered a …
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Non-Coding Rnas Identify The Intrinsic Molecular Subtypes of Muscle-Invasive Bladder Cancer
… INTRINSIC MOLECULAR SUBTYPES OF MUSCLE-INVASIVE BLADDER CANCER</strong></p> <p>Andrea Elizabeth Ochoa, B.S.</p> <p>Advisory Professors: David J. McConkey, Ph.D. and Joya Chandra, Ph.D.</p> <p>There has been a recent explosion of genomics data in muscle-invasive bladder cancer (MIBC) to better …
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Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane
… (MDR) describes the phenomenon whereby cancer cells<br/>exposed to a single cytotoxic drug develop cross resistance to numerous other<br/>structurally unrelated chemotherapeutics. The development of MDR is a major<br/>cause of cancer chemotherapy treatment failure in all types of …
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Strategies to Sensitize Bladder Cancer Cells to Small Molecule Inhibitors Targeting The Pi3K Pathway
<p>After many years of cancer research, it is well accepted by the scientific community that the future cure for this disease lies in a personalized therapeutic approach. Anticipating therapeutic outcome based on the genetic signature of a tumor has become the new paradigm. The PI3K pathway …
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Dynamic Contrast-Enhanced MRI and Diffusion-Weighted MRI for the Diagnosis of Bladder Cancer
It is estimated by the American Cancer Society that there will be about 72,570 newly diagnosed cases of bladder cancer (about 54,610 in men and 17,960 in women) and about 15,210 (about 10,820 in men and 4,390 in women) deaths from bladder cancer in 2013. Early detection and accurate staging of …
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Mechanisms Underlying Distinct Egfr Versus Fgfr-3 and -1 Dependency In Human Bladder Cancer Cells
… amplification, mutation and overexpression in bladder cancer, which drives tumor development and progression. Both EGFR and FGFR inhibitors are currently being tested in clinical trials. However, bladder cancer (BC) cells show remarkably heterogeneous sensitivities to both inhibitors, and the …
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