Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 100 for “"Bivalent"”.
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BIVALENT SOCIAL FREEDOM: A DEFENCE
When I am unable to drive due to a road blockade, there seems to be a morally relevant difference between a case in which the road is blocked by some workers (involved, say, in road works or a strike) and a case in which the road is blocked by a naturally occuring landslide. Many social and …
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Structural studies on some bivalent metal complexes.
Previous investigations of the solid-state structures of (R[3]P)[2]HgX[2] and (R[3]P)HgX[2] complexes have been extended by the determination of the following crystal structures: (1) (Ph[3]P)[2]HgCl[2] (2) (Cy[3]P)HgCl[2]. The structure of (Ph[3]P)[2]HgCl[2] is that of a discrete monomer with a …
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“CLICKED” BIVALENT MULTIFUNCTIONAL LIGANDS IN ALZHEIMER’S DISEASE.
… recently we have embarked on the development of bivalent multifunctional Aβ oligomerization inhibitors (BMOIs) as potential AD-modifying agents. These BMAOIs contain curcumin as the multifunctional moiety and cholesterol as the CM/LR anchorage moiety linked by a spacer to co-target AβOs, CM/LR, …
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MODULATION AND INTERACTIONS OF CHARGED BIOMIMETIC MEMBRANES WITH BIVALENT IONS
… PtdIns and DOPG monolayers and its modulation by bivalent ions using Langmuir monolayers. In addition, a theoretical framework of compressibility that depends on a surface potential induced by a planar layer of charged molecules and ions in the bulk was provided. In the third part, I present my …
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Candidate Bivalent HCV Vaccine: A Novel Approach To Vaccine Design for Hyper-variable Viruses
… our approach was used to develop a bivalent HCV vaccine explicitly designed to elicit AB to HVR1 (hypervariable region 1), the most variable epitope of any known human pathogen. Remarkably, the polyclonal response induced by vaccination was pan-genotypically neutralizing. These …
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Development of an Antibiotic Resistance Free Bivalent Vaccine Against Swine Brucellosis and Swine Influenza
… that caused a pandemic. To develop an effective bivalent vaccine for swine against these two diseases, a leucine auxotroph of the USDA approved vaccine B. abortus strain RB51 was constructed along with leuB gene complementing plasmid pNS4 to over-express antigens from Brucella and influenza. This …
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Synthesis and Biological Evaluation of Coactivator Binding Inhibitors and Bivalent Ligands for the Estrogen Receptor
The synthesis of steroidal bivalent ligands for ER is also reported. Two estradiol molecules were connected through a phenylethynyl linkage with chemical tethers of varying composition and length. The binding properties of the bivalent ligands for ER were measured. Moderate relative binding …
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Geometrical Requirements for Nucleophilic Substitution at Bivalent sulfur(II) and sulfur(VI): An Application of the Endocyclic Restriction Test
Embargo set by: Seth Robbins for item 85782 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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Elucidating the role of the EGFR-family members in cell motility through the use of novel engineered bivalent ligands
… This thesis describes the use of engineered bivalent ligands to systematically manipulate receptor dimerization, perturb downstream signaling processes, and affect phenotypic outcomes. Results showed that biasing away from an EGFR-HER-2 with a bivalent ligand reduces cell motility …
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Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
… such as fluorine-18 radiopharmaceuticals, bivalent ligands, and affinity labels, provide information toward a better understanding of ER localization, structure, and function. We have prepared two fluorinated analogs of 2-oxohexestrol as potential diagnostic imaging agents for ER-responsive …
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MET-2 and SET-25 have sexually dimorphic effects on chromosome structure in Caenorhabditis elegans
… In C. elegans, we found that the bivalent length of diakinesis oocytes is significantly longer than spermatocytes. In addition, we found that mutations in different genes involved in histone post-translational modifications have distinct impacts on oocyte and spermatocyte bivalent …
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GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA
… engineer anti–IL3Rα–IL3Rα and anti–IL3Rβ–IL3Rβ bivalent and anti–IL3Rβ–IL3Rα bispecific antigen binding fragments (Fabs) to enhance targeting of CML cells. SpyCatcher-SpyTag system was used to join IL3Rα / IL3Rβ mono–Fabs by a covalent bond. The bivalent and bispecific Fab formats against IL3Rα, …
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Antibody engineering to evaluate binding, internalisation, and intracellular routing of tumour-targeting fusion proteins
… internalisation, and therapeutic efficacy, a bivalent scFv fusion protein was created in tandem with the standard monovalent fusion protein. In vitro experiments using fluorophores and the cytotoxin, monomethyl auristatin F (AURIF), demonstrated that the bivalent fusion protein exhibited …
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Lithiation of Alkyl 2,6-Substituted Benzoates Adjacent to Oxygen: Alpha-Lithioalkyl Alcohol Synthons
The removal of an sp('3) proton alpha to the bivalent oxygen of an ether or alcohol to generate a formal stable (alpha)-oxocarbanion is unknown. However, formation of an (alpha)-lithio alcohol derivative from an ester might be feasible because the formally bivalent oxygen has a partial positive …
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The synthesis of 5-HT2 receptor designed multiple ligands to investigate the role of the 5-HT2AR and the 5-HT2CR in cocaine addiction
… order to target these GPCR dimers and oligomers bivalent ligands have been synthesized. Previously synthesized bivalent ligands have demonstrated increased affinity and potency when compared to administration of the monomers. The aim of this project is to synthesis homodimeric 5-HT2A R …
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Basic studies of chiasma frequency in male Blattella germanica (L.)
… data showed a decrease in mean chiasmata per bivalent: 1.3325 ± 0.0184 for the first oothecal group, 1.2999 ± 0.0165 for the second oothecal group, and 1.2525 ± 0.0113 for the third oothecal group. The variances decline with the means. The chiasma frequency of a stock heterozygous for a …
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
… prostate cancer cell lines. In addition, a bivalent ligand containing both a mu opioid receptor (MOR) and a CCR5 antagonist pharmacophore was designed and synthesized in order to study the pharmacological profile of the putative CCR5-MOR heterodimer and its relation with NeuroAIDS. The …
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Development of novel strategies to combat multidrug resistance mediated by efflux transporters and intracellular bacteria
… the very drug substrates, we have developed bivalent inhibitors of P-gp. Here, click chemistry has been utilized to rapidly synthesize a library of dimers based on emetine and quinine. This resulted in triazole bearing dimers that potently inhibited P-gp efflux. Bivalent quinine probes were …
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DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS
… pharmacophoric component parts. We synthesized bivalent derivatives formed by a) a D2/D3 agonist moiety and a nicotinic alpha4beta2 antagonist fragment and b) a D2/D3 antagonist moiety and a nicotinic alpha4beta2 agonist fragment. The structures of the parent ligands were selected after a …
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