Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Bispecific Antibodies"”.
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Development of a novel antibody molecule for redirected T cell immunity to tumor cells: The bispecific single chain antibody
… proteins and the production of monoclonal antibodies that bind them allow the specific targeting of cancer cells. A promising use for these anti-tumor antibodies involves redirecting a patient's own cytotoxic T cells (CTL) to specifically kill tumor cells by the use of a bispecific …
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biological treatment options of multiple myeloma
… These include proteosome inhibitors, monoclonal antibodies, Chimeric antigen receptor T cells, T cell engaging bispecific antibodies, antibody-drug conjugates along with steroids, and immunomodulatory therapies. Bortezomib, Carfilzomib, and Ixazomib are examples of proteasome inhibitors. …
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De novo synthesis of high purity CD3 epsilon peptides utilizing SUMO expression system in bacteria
… drugs for many diseases. Among the monoclonal antibodies, T cell-dependent bispecific antibodies directly target tumor cells for cancer treatment, they kill tumor cells by activating T cells through binding to the CD3 (cluster of differentiation 3) receptor on T cells. Many anti-CD3 antibodies …
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Met inhibitors στον μη μικροκυτταρικό καρκίνο του πνεύμονα / Met inhibitors in non–small cell lung cancer
… προσεγγίσεις όπως antibody–drug conjugates, bispecific antibodies και συνδυαστικές στρατηγικές αναμένεται να διευρύνουν περαιτέρω το θεραπευτικό πεδίο, ενώ η ολοκληρωμένη μοριακή χαρτογράφηση παραμένει κρίσιμη για την ορθή επιλογή ασθενών.
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Development of an Optogenetic Toolkit for the Interrogation of T cell Signalling Dynamics
… over several timescales. T cell-dependent bispecific antibodies (TDBs) are a new class of immuno-therapeutics that can specifically direct a T-cell response towards tumours, by crosslinking the TCR complex to a surface- expressed target on the cancerous cells. However, their mechanism of …
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Construction and characterisation of anti-tumour antibody-based proteins for use in diagnostics and therapeutics
Considerable success in the use of monoclonal antibodies (mAbs) as a targeted approach to cancer therapy has stimulated rapid development in this field of research. Due to the complex nature of the tumour microenvironment many novel antibody formats have been designed to expand on the therapeutic …