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Showing 1 to 5 of 5 for “"Bisnaphthalimidopropyl"”.
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Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system.
The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives has gained pace over the last couple of years, as they have enhanced aqueous solubility without loss of biological activity in contrast to parent bisnaphthalimide derivatives. Recent work has shown that …
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Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies.
… cancer therapies. Research work has shown that bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) exerts potent in vitro anti-cancer activities and strong DNA binding properties. The aim of this thesis was to synthetise novel bisnaphthalimidopropyl derivatives (BNIPs) and investigate …
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Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines.
… latest generation of BNIP derivatives including bisnaphthalimidopropyl-piperidylpropane (BNIPPiProp), bisnaphthalimidopropyl- ethylenedipiperidine (BNIPPiEth) and bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) have been studied against SW480 and SW620 colorectal cancer cell lines. …
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Novel polyamine based anticancer agents: evaluation of the mode of action.
Novel bisnaphthalimidopropyl polyamine analogues (BNIPPs) were previously synthesised and found to bis-intercalate to DNA via the major groove and have interesting anticancer properties prompting this study to evaluate their mode of action. All BNIPPs synthesised exert cytotoxicity in colon, breast …
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The use of novel poly(allylamine) based amphiphilic polymers for drug delivery.
… used to solubilise the novel anticancer agent Bisnaphthalimidopropyl diaminooctane (BNIPDaoct) which was otherwise insoluble achieving a solubilisation of 0.3 mgmL-1. The sizes of the optimal formulations differed greatly for both modified polymers. This was possibly due to the varying …