Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Bisindolylmaleimide"”.
-
Design, synthesis and development of novel indolocarbazole derivatives as potential anti-cancer agents
… out on the design of new routes to a range of bisindolylmaleimide and indolo[2,3-a]carbazole analogs, and investigation of their potential as successful anti-cancer agents. Following initial investigation of classical routes to indolo[2,3-a]pyrrolo[3,4-c]carbazole aglycons, a new strategy …
-
Signaling By Protease-Activated Receptors in Gastrointestinal Smooth Muscle
… preferentially inhibited by the PKC inhibitor bisindolylmaleimide and to a minor extent by the Rho kinase inhibitor Y27632, whereas PAR2-induced sustained contraction was preferentially inhibited by Y27632. Activation of both PARl and PAR2 induced MLC20 phosphorylation, whereas phosphorylation …
-
k-Opioid Receptor Dependent Cardioprotection in the Rat
… PKC inhibitors chelerythrine chloride (2 mM) and bisindolylmaleimide (100 nm). Confocal microscopy and Western blot analysis of isolated ventricular myocytes showed translocation of PKC-e and -d to the myofibrillar fraction with U50 treatment. U50 increased myofibrillar Ca2+-independent PKC …
-
Synthesis and evaluation of novel azaindolocarbazole derivatives as cancer chemotherapeutics
… derivatives of the indolocarbazole (ICZ) and bisindolylmaleimide (BIM) families, with subsequent evaluation for use as cancer chemotherapeutic agents. A robust synthetic strategy was devised to allow the introduction of a 7-azaindolyl moiety into our molecular template. This approach allowed …
-
Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
… Cl-am) and Protein Kinase C inhibitor, Bisindolylmaleimide-I (Bis-I) exhibited extensive EV inhibition in PC3 and MCF-7 cells. This effect was further tested using an Annexin-V-based apoptosis assay and VB-48 vitality assay through image FCM. There was a significant increase in …
-
Redox mechanisms in retinal cells
… expression was dose-dependently suppressed by Bisindolylmaleimide I (a protein kinase C inhibitor) and LY294002 (a phosphionositide 3-Kinase (PI3K) inhibitor). These results suggest that Mueller cells may be more resistant to oxidative stress than other retinal cell types and that SFN utilises …
-
Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
… indolotryptoline, carboxy-indolocarbazole, and bisindolylmaleimide), consisting of 15 novel natural products (e.g. BE 54017s, borregomycins, erdasporines) with therapeutically relevant bioactivities (e.g. antitumor, antibacterial). Linking biologically active natural products to their cellular …
-
Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life
… similar to NPC fibroblasts. Inhibition of PKC by bisindolylmaleimide 1 (Bis-1) treatment of 1c1c7 cultures favored the formation of filamentous vimentin, accumulation of non-esterified cholesterol and autophagosomes, and decreased GFP-LC3 and LAMP1 colocalization. Confocal microscopy revealed that …
-
Unique localization of protein kinase C isozymes in T51B rat liver cells and their role in proliferation and apoptosis.
… and -$\zeta.$ Furthermore, the PKC inhibitor bisindolylmaleimide (Bis) enhances apoptosis while TPA reduces the number of cells undergoing apoptosis. (Abstract shortened by UMI.)