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Showing 1 to 5 of 5 for “"Bis-amino acid"”.
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CONSTRUCTING NANOSTRUCTURES WITH ATOMIC PRECISION: THE SYNTHESIS OF SPIROLIGOMER-BASED MACROCYCLES
… proteins. “Spiroligomers” (formerly known as “bis-peptides”) are a class of molecules produced by the assembly of “bis-amino acids”, molecules containing two amino acid regions on a single cyclic core. Each bis-amino acid is connected through pairs of amide bonds to form a diketopiperazine …
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Design, synthesis, and structural elucidation of spiroligomers for targeted molecular recognition
… scaffolds assembled from stereochemically pure bis-amino acid building blocks. By controlling backbone stereochemistry, spiroligomers enable precise and predictable three-dimensional presentation of side chains, offering a level of conformational control that extends beyond conventional …
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Progress Toward The Total Synthesis Of The Natural Product Herbicide Ascaulitoxin Aglycone
Ascaulitoxin aglycone is a structurally unique bis-amino acid isolated from the fungal species Ascochyta caulina, with herbicidal activity against Chenopodium album. Ascaulitoxin aglycone's potent herbicidal activity coupled with an unknown but novel mechanism of action makes it a perfect candidate …
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Preparation of arylphosphinic acid derivatives as building blocks for binding sites
… have been designed and prepared from a novel bis amino acid, bisphenylalanylphosphinic acid. The synthesis starts by making 4-iodophenylalanine, for which a greatly improved preparation has been developed. With this method, multi-gram quantities of 4-iodo-(S)-phenylalanine can be obtained …
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Synthesis of coordination complexes and the use of X-ray diffraction data towards the development of refinement of occupancy of spherical atoms (ROSA), a new approach for the determination of atomic partial charges
… for attachment to a rigid bis-amino acid macromolecule scaffold to template an artificial enzyme active site, but proved unsuccessful. Synthetic efforts toward the macrocycle development is discussed within. Subsequently, (R)-1-(pyridin-2-ylmethyl)pyrrolin-2-yl)methanol was …