Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Bis-Sulfoxide"”.
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Development of palladium catalyzed intramolecular allylic C―H amination and oxidation towards pharmacological motifs
… streamlining of total synthesis. Using Pd(II)/sulfoxide catalysis, the White group has made significant developments in the area of allylic C―H oxidation and functionalization reactions. Using these methodologies, a variety of pharmacologically relevant small molecules have been synthesized in …
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Palladium (II) / sulfoxide - promoted strategies for efficient and selective allylic C-H oxidations
… improved chemical efficiency. Palladium(II) / sulfoxide catalysis has demonstrated broad applicability toward a wide array of allylic C–H functionalizations, starting from abundant and simple α-olefins. The development of such transformations has been classically guided by the reaction’s serial …
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Synthetic diversity in C-H activation: development of selective and efficient C-H functionalization reactions
… mechanism as a result of switching from a Pd(II)/bis-sufloxide catalyst to a Pd(OAc)2 catalyst. Our group has previously shown that the terminal oxidant in our Pd(II)/bis-sulfoxide catalyzed systems, benzoquinone (BQ), also serves as a ligand to Pd in order to promote functionalization from a …
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Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs
… merging of Brønsted acid catalysis with Pd(II)/bis-sulfoxide catalyzed allylic C-H oxidation to achieve the synthesis of vinyl-oxazolidinones from simple homoallylic, N-Boc protected amines. It is shown that utilization of dibutylphosphate as a co-catalyst with a Pd(II)/bis-sulfoxide catalyst …
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Selective C—H oxidations for complex molecule synthesis and diversification
… of α-olefins as starting materials, a Pd(II)/bis-sulfoxide catalyst is utilized to carry out a selective intramolecular allylic C—H oxidation to generate a versatile synthetic intermediate (1,4-dioxanones). In contrast to many C—H oxidations, which transform a simple starting material into a …
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Asymmetric allylic C–H functionalization via palladium(II)/sulfoxide-oxazoline catalysis
… Alternatively, the oxidatively stable bis-sulfoxide ligand has shown to promote general reactivity with broad scope. However, its underlying mechanism, known as “serial ligand catalysis”, is challenging for asymmetric catalysis, due to the highly dynamic and fluxional binding …
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Improving synthetic efficiency through C—H activation
… the discovery of a heterobimetallic Pd(II)bis-sulfoxide/(Salen)Cr(III)F catalyst system for asymmetric allylic C—H oxidation of terminal olefins. Evidence is provided that supports a model in which a chiral Lewis acid co-catalyst interacts with an organometallic intermediate and influences …
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C—H oxidation reactions in complex molecule synthesis: application and development
… materials in a rapid fashion. We report a Pd(II)/bis-sulfoxide catalyzed dehydrogenative Diels-Alder reaction that converts simple terminal olefins into complex cyclohexenyl adducts in good yields and selectivities. Based on the high functional group tolerance, this method enables expedient access …