Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 74 for “"Birth defects"”.
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IRON OVERLOAD AND BIRTH DEFECTS
Large, intravenous doses of iron-dextran are teratogenic in a number of laboratory species (M Phil). To elucidate the mechanism, studies were performed in rats and rabbits to identify possible maternal, placental and foetal sites of action. Maternal toxicity, manifested by bodyweight depression, …
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Human chromosomes: structure, abnormalities and birth defects
… of human chromosomes and their relationship to birth defects. A new technique is described to produce spiralization of human metaphase chromosomes. The important feature is heat followed by trypsin treatment. By varying conditions, it is possible to produce bands, spirals and intermediate …
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Maternal grief reactions to their children's birth defects: factors influencing grief resolution
… to the event of learning about their child's birth defects. Subjects were 63 mothers and their toddler-age children, recruited from medical clinics in the Metropolitan area of Detroit, MI. Mothers' ages ranged from 18 to 42 years (mean = 30 years). 63% (n = 40) of the families were Caucasian, …
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The Association of Specific EPHX1 and GSTM1 Gene Polymorphisms with Phenytoin- or Smoking-Associated Birth Defects
… the products of cigarette smoke leads to reduced birth weight, prematurity, and small but significant risk of oral clefts. Cleft lip/palate occur at a frequency of 1 per 750 to 1000 livebirths in the United States. Microsomal epoxide hydrolase (mEH) participates in xenobiotic metabolism, including …
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Surgical care of children born with birth defects in low and middle income countries [LMICs] using anorectal malformation [ARM] as a case study
Birth defects, also known as congenital anomalies, are one of the leading causes of infant mortality and lifelong disabilities worldwide. They disproportionately affect low and middle income countries [LMICs], where limited healthcare services, financial hardship, and societal stigma further …
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Thalidomide-induced teratogenesis in gray short-tailed opossums (Monodelphis domestica)
… and was later discovered to cause serious birth defects. Thalidomide is currently being prescribed to treat erythema nodosum leprosum and multiple melanoma, and is being considered for other anti-angiogenic applications. This is of concern, as the mechanisms by which thalidomide disrupts …
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Ethnic Identity and Teratogenic Risk Perceptions
… estimated an elevated baseline risk of 25% for birth defects among the general population. In addition, participants overestimated birth defect risks for specific exposures, such as alcohol and marijuana. Based on the MEIM scores, ethnic identity was not significantly associated with teratogenic …
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Damaged goods? Clinical conversations and the cultural construction of cocaine-exposed children in foster care
… poor social bonding was reported as were various birth defects, in the children of multiply addicted women who used cocaine. By the early 1990s, the reality of these effects and their causal link to cocaine was largely taken for granted."
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The Novel Role of Dnmbp In Kidney Development
… (CAKUT) accounts for nearly one-fourth of all birth defects and more than 40% of pediatric end-stage renal disease, yet only 10-20% of CAKUT cases have a known monogenetic cause. Human kidneys are composed of up to a million epithelial tubules called nephrons. Disruption of nephron development …
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Proepicardial Cell Differentiation During Cardiac Development
… fibrous ECM proteins. Since AV valve and sepal birth defects are amongst the most common of all birth defects, delineating molecular mechanisms of their formation is critical. We further suggest that understanding the mechanisms of valve formation, and specifically the role of these multipotent …
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Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice
… is a possible mechanism for teratogen-induced birth defects. Neural tube defects (NTDs) are the second most common fetal malformations. Non-specific stimulation of maternal immune system prevents birth defects. This study investigated the role of dysregulated apoptosis in formation of NTDs from …
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Structural Studies On The Rubella Virus Capsid Protein And Its Organization In The Virion
<p>Rubella virus is a leading cause of birth defects due to infectious agents. When contracted during pregnancy, rubella infection leads to severe damage in fetuses. Despite its medical importance, very little is known about the structure of the pleomorphic rubella virus as compared to its …
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Analysis of cell cycle surveillance mechanisms in meiosis
… that could lead to spontaneous abortions, birth defects and cancer predisposition in the offspring. Two such surveillance mechanisms are analyzed in this thesis. The first is the meiotic recombination checkpoint, which delays meiotic cells in G2/prophase if recombination intermediates …
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A Proof-of-Concept Application of Principal Component Analysis For Identification of Anatomical Variations in Pharyngeal Flap Patients Experiencing Persistent Velopharyngeal Insufficiency
Cleft palates are one of the most common birth defects across the globe. The repair of cleft palates often includes the addition of a pharyngeal flap to assist with closure between the nasal and oral cavities. The failure rate of the pharyngeal flap placement is up to 30%, resulting in persistent …
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
… in the United States, and 2% of all live births have some form of malformation. While many of these malformations have known genetic or environmental causes, others have eluded explanation. These conditions are thought to be caused by complex interaction between genetic and environmental …
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
Each year, 7.9 million babies are born with birth defects. Seventy percent of those could be prevented, ameliorated, or repaired; yet 3.2 million children still die by the age of three (March of Dimes Global Report 2006). We have found that non-specific maternal immune stimulation with the cytokine …
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Attitudes of Clinicians to wards Cardiac Surgery and Trisomy 18
… trisomy characterized by minor to major birth defects, severe disabilities, and high rates of pre- and neonatal mortality. Interventions for these infants have traditionally been withheld with focus instead on palliative support. The issues and attitudes surrounding surgical treatment of …
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