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Showing 1 to 20 of 28 for “"Birth defect"”.
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
Each year, 7.9 million babies are born with birth defects. Seventy percent of those could be prevented, ameliorated, or repaired; yet 3.2 million children still die by the age of three (March of Dimes Global Report 2006). We have found that non-specific maternal immune stimulation with the cytokine …
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Congenital Palatopharyngeal Incompetence (Cpi): The Natural History of a Late Appearing Birth Defect Manifest by Hypernasality
Made available in DSpace on 2014-12-14T05:26:40Z (GMT). No. of bitstreams: 1 7616086.pdf: 5558059 bytes, checksum: 14011dfb420af2d2ee49d9ece959f761 (MD5) Previous issue date: 1976
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Systematic review of speech and language intervention for young children with cochlear implants : a guide for speech language pathologists
… 3 newborns in 1,000 making it the most common birth defect. Current widespread use of universal newborn hearing screening has resulted in an average age of identification of hearing loss of 2-3 months. As the population of children who are identified early in life and fitted with cochlear …
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Fluid Flow Forces Regulate Fibrous Extracellular Matrix Protein Expression and Deposition Via A Rhoa/Rho Kinase Dependent Pathway During Atrioventricular Valve Development
<p> Today, congenital heart defects are collectively the most common birth defect as well as the leading cause of birth defect related deaths, which often require surgical procedures, a lifetime of medications and preventative measures on the patient to maintain a working heart and a healthy body. …
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Ethnic Identity and Teratogenic Risk Perceptions
… estimated an elevated baseline risk of 25% for birth defects among the general population. In addition, participants overestimated birth defect risks for specific exposures, such as alcohol and marijuana. Based on the MEIM scores, ethnic identity was not significantly associated with teratogenic …
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Identifying Genetic Variants and Characterizing Their Role In Clubfoot
<p>Clubfoot is a common, complex birth defect affecting 4,000 newborns in the United States and 135,000 world-wide each year. The clubfoot deformity is characterized by inward and rigid downward displacement of one or both feet, along with persistent calf muscle hypoplasia. Despite strong evidence …
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AN URBAN BIOETHICS APPROACH TO UNDERSTANDING DISPARITIES IN NEURODEVELOPMENTAL OUTCOMES FOR CHILDREN WITH CONGENITAL HEART DISEASE
Congenital heart disease (CHD) is the most common birth defect and often resultsin neurodevelopmental impairments and psychological problems which impede educational and occupational attainment and decrease overall quality of life into adulthood. While morbidity and mortality outcomes have improved …
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Fzd6, Matn2 and Slc25A32, Possible Candidate Genes In Nonsyndromic Cleft Lip and Palate
… with or without cleft palate (NSCLP) is a common birth defect with a multifactorial etiology. Despite decades of research, the genetic underpinnings of NSCLP still remain largely unexplained. A genome wide association study (GWAS) of a large NSCLP African American family with seven affected …
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Contractile Properties of Striated Muscle in Development and In Disease
… time for muscle formation, and muscle-related birth defects are sometimes linked to mutations in muscle contractile proteins expressed in utero. Even in heart disease, the development of the disease pre-dates the clinical symptoms; however, studying the developing muscle before it presents in …
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Analysis of Human Face Shape Abnormalities Using Machine Learning
… with cleft lip and/or palate. Cleft lip is a birth defect that results in deformity of the upper lip and nose. Its severity is widely variable and the results of treatment are influenced by the initial deformity. Objective assessment of severity would help to guide prognosis and treatment. …
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Analysis of Variation In Clubfoot Candidate Genes
Isolated clubfoot, a common birth defect occurring in more than 135,000 livebirths worldwide each year, is associated with significant health care and financial burdens. Clubfoot is defined by forefoot adduction, hindfoot varus, midfoot cavus and hindfoot equinus. Isolated clubfoot, which is the …
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
<p>Congenital heart defects (CHDs) are the most common human birth defect, occurring in ~1/100 newborns, and are a leading cause of early infant death. Cardiac neural crest cells (NCCs) are a migratory and multipotent cell population known to aid in the development of the cardiac outflow tract …
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Long Term Follow-Up of Morbidity and Quality of Life Associated With Isolated Gastroschisis
<p>Gastroschisis is a birth defect in which an opening in the abdominal wall allows herniation of the viscera. Prenatal counseling regarding gastroschisis typically discusses that, although these infants often endure a difficult neonatal course, they experience few long-term complications. However, …
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Gene Discovery In Nonsyndromic Cleft Lip With Or Without Cleft Palate
… palate (NSCLP), a common, complex orofacial birth defect that affects approximately 4,000 newborns each year in the United States, is caused by both genetic and environmental factors. Orofacial clefts affect the mouth and nose, causing severe deformity of the face, which require medical, …
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Assessment of fetoscopic tracheal occlusion using ultrasound images in phantom study
Congenital Diaphragmatic Hernia (CDH) is a birth defect that affects approximately 1 in 2000-5000 neonates. Most of the CDH cases are isolated, which means that affected individuals have no other major malformations. The diaphragm is a muscle that separates the chest from the abdomen. Incomplete …
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
… Shh results in polydactyly. Polydactyly is a birth defect characterized by the presence of more than the normal number of fingers or toes. This defect with or without associated malformation(s) is found to be 5 to 19 in every 10000 births. To further understand the etiology of abnormal limb …
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Univariate and Multivariate Surveillance Methods for Detecting Increases in Incidence Rates
… the incidence of a given disease, infection or birth defect. Observations are regularly taken in which either an incidence occurs or one does not. This dissertation contains the result of an investigation of prospective monitoring techniques in two distinct surveillance situations. In the first …
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Molecular genetic investigation of autosomal dominant hemifacial microsomia
… to one side of the face and is a common birth defect with an estimated incidence of 1 in 1,000 to 1 in 5.600 births. Most HFM cases are sporadic, but there are rare familial cases that exhibit autosomal dominant inheritance. These families present the best opportunity for locating and …
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Xenobiotic Metabolism Genes and Clubfoot
… or isolated clubfoot is a common orthopedic birth defect that affects approximately 135,000 children worldwide. It is characterized by equinus, varus and adductus deformities of the ankle and foot. Correction of clubfoot involves months of serial manipulations, castings and bracing, with …
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Effect of Anchoring On Perceived Amniocentesis Related Miscarriage Risk Within A Latina Population
… a 3-5% background risk to have a child with a birth defect. Amniocentesis, the most common type of prenatal diagnostic test, is used to detect chromosomal abnormalities, such as Down syndrome. Amniocentesis is associated with a risk of complications that can lead to a miscarriage, which is …
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