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Showing 1 to 2 of 2 for “"Birinapant"”.
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
… activator of caspase (SMAC) mimetic, Birinapant, when combined with pan-caspase inhibitors zVAD-FMK or emricasan. Strikingly, inhibition of CASP8 function via knockdown or emricasan treatment was associated with enhanced radiation killing by Birinapant through induction of necroptosis. …
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SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
… of caspases (SMAC) mimetic (AEG 40730, LCL-161, birinapant) to kill the latently HIV-infected lymphocytic cell line J1.1 and myelocytic cell line OM10.1. In HIV-infected cell lines, it was shown that the order of administration of MG1 and SMAC mimetics is important to optimize killing. Moreover, …