Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Bipotential"”.
-
Morphogenesis and Female Fate Determination in Vertebrates
… organs, the testis and the ovary, from a single bipotential primordium. The outcome of this decision, which is made by a population of somatic cells known as the bipotential supporting cell precursors, determines whether an embryo will develop as a phenotypic male or female. Though several …
-
Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …
-
Anwendungen der getrennt konvexen Funktionale in der Mechanik
… is explored. Characterization theorems for the bipotential are given. Relations to other convexity notions, as well as consistent definitions of separately convex hulls are studied in the sequel. The biaffine hull is introduced as a natural generalization of the affine hull from convex analysis. …
-
C/EBPalpha downregualtes c-jun expression
… block TPA induced monocytic differentiation of bipotential myeloid cells. In C/EBPa knockout mice, no mature granulocytes are present. A dramatic increase of c-jun mRNA in C/EBPa knockout mice fetal liver was observed. c-jun, a component of the AP-1 transcription factor complex and a …
-
Beta-Catenin and Development of the Urogenital System
… The Wolffian or M��rian ducts, along with the bipotential gonads, will develop into the male or female reproductive tracts,respectively. Although many signals are involved in development of the urogenital system, canonical Wnt/beta-catenin signaling is known to play a significant role. To …
-
Integrin α2 and Akt in early hematopoiesis
… not expressed in the immature CD34+CD38-CD45RA- bipotential megakaryocyte-erythrocyte progenitors in human bone marrow, providing a means for enriching this novel bipotent progenitor population for further studies on early megakaryocytic and erythroid lineage fate decisions. In addition, we …
-
The mesenchymal regulation of ductal-driven liver regeneration
… compromised, ductal cells become activated into bipotential progenitors to replace lost epithelium. This process can be recapitulated in vitro by growing hepatic ductal cells under defined extracellular matrix and growth factors, which generates 3D epithelial 'liver organoids' that resemble adult …
-
Mapping Human Liver Development using Single-Cell Transcriptomics to Reveal Pathways Directing Stem Cell Fates
… We utilised this information to derive bipotential hepatoblast organoids and used this novel model system to validate the importance of key signalling pathways and developmental cues. Currently, hPSC-derived hepatocytes do not directly resemble their primary tissue counterparts and have …
-
Human Liver Organoids as models for investigating drug-induced liver injury
… of the tissue of origin, and to retain the bipotential ability to differentiate into hepatocyte organoids. In this Thesis, we generated an enhanced hepatocyte organoid system through the directed stepwise differentiation in vitro of progenitor liver organoids using chemically defined culture …
-
Creation of organoid systems to model human endodermal organ development in vitro
… explored as the HBO were demonstrated to have bipotential capacity to generate hepatocytes and cholangiocytes. Furthermore, these organoids were then transplanted into mice and were able to differentiate into complex functional tissues. Next, a newly discovered stem cell was characterised and …
-
Exploring the Multifaceted Life of Beige Adipocytes
… beige adipocytes. This cell type appears to be bipotential, capable of giving rise to both beige and white adipocytes. Their thermogenic fate is primarily driven by a postnatal surge in circulating thyroid hormone, likely mediated through thyroid hormone receptor beta. We also revealed that …