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Showing 1 to 20 of 825 for “"Biowissenschaften, Biologie"”.
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Zum Mechanismus der Informationsverarbeitung und Energiewandlung in biologischen Rezeptoren: ein allgemeines membranstrukturbezogenes Transducermodell / On the transaction mechanism in biological sensors
THESEN Zur Dissertation "Zum Mechanismus der Informationsverarbeitung und Energiewandlung in biologischen Rezeptoren. Ein allgemeines membranstrukturbezogenes Transducermodell" von Bernd Blobel 1. Die Untersuchung und Aufklärung der Funktionsprinzipien bei der Informationsverarbeitung und …
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Flavonoidinduzierte phänotypische Plastizität in der Flügelfärbung des Bläulings Polyommatus icarus (Lepidoptera: Lycaenidae) und ihre Bedeutung für Partnerwahl und Arterkennung
Ich berichte über den ersten bekannten Fall, bei dem sequestrierte sekundäre Pflanzeninhaltsstoffe das äußere Erscheinungsbild eines Insekts im ultravioletten (UV) Spektralbereich verändern und dadurch die visuell vermittelte Partnerwahl beeinflussen. In jüngerer Zeit wurden zunehmend Daten …
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Characterization of a human renal organic anion transporter
The renal excretion of organic anions, including a variety of endogenous substances, xenobiotics and their metabolites, involves an organic anion transport system with multiple specificity. The well characterized basolateral uptake step of this process involves the organic anion transporter 1 …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
Transforming growth factor (TGF)-beta is a key mediator of hepatic stellate cell (HSC) activation and extracellular matrix accumulation leading to fibrosis. Aim of the present study was to perturb the TGF-beta pathway in this process by overexpression of Smad7, an intracellular antagonist of …
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Antiapoptotische Wirkungen des Makrophagen-migrationsinhibierenden Faktors (MIF) auf das Tumorsuppressorprotein p53 bei der ROS-induzierten Apoptose
In the present thesis, intrinsic (ROS -> p53-activation / ROS -> mitochondrial apoptosis) and extrinsic (PI3K-Akt-Pathway) effects of the cytokine MIF (Macrophage Migration Inhibitory factor) have been examined and brought in connection with antiapoptotic and pro-proliferative effects. The …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
Stimulation of the IL-6R complex leads to activation of the Jak/STAT (Januskinase/Signal Transducer and Activator of Transcription)-pathway and the Ras/Raf/MAPK-cascade. The protein tyrosine phosphatase SHP2 (SH2 - containing tyrosine phosphatase) is recruited to gp130, the signaltransducing …
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Antikörperfragmente und synthetische Antigene für die Diagnose von Viruserkrankungen der Pflanzen
The detection of Beet necrotic yellow vein virus (BNYVV) in stored sugar beets by means of monoclonal antibodies or antibody single chain fragments (scFv) often poses problems, because the immunodominant C-terminal epitope of the viral coat protein is readily lost due to proteolysis. Recombinant …
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Antikörper vermittelte Fusarien-Resistenz in transgenen Pflanzen
Pathogenic fungi lead to large yield losses in agriculture and in ornamental plant production. They attack plants as well as seeds and contaminate them with mycotoxins and other metabolites. Resistant wild type species are often not available, so the only possibility to combat fungal pathogen is …
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Physiologische und genetische Charakterisierung der Gamma-Aminobutyrat-(GABA)-Aminotransferase in Rhizobium leguminosarum bv. viciae VF39
In the frame of this work the gabRTD region of Rhizobium leguminosarum bv. viciae VF39 was identified and systematically analysed. Starting from a Tn5-B20 mutant PH10 which was found to show increasing induction of the lacZ-reporter on low pH media, the transposon was cloned and 2.5 kb of flanking …
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Klonierung und funktionelle Charakterisierung des Extraneuronalen Monoamin-Transporters (EMT) des Hausschweins
Together with the other members of the non-neuronal monoamine-transporter family, EMT is responsible for the re-uptake of catecholamines and monoamines after their release into the synaptic cleft and from the circulation. EMT in fact transports other organic cations and its expression at excretion …
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Stem cell transplantation in mouse models for Huntington's disease
Cell replacement therapies for neurodegenerative diseases using stem cells require above all a good survival of the graft and therefore an understanding of the possible influence of the surrounding degenerating tissue on the grafted cells. In this thesis, I report on the experiments of stem cell …
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Cloning and characterization of th BPR1 gene ('Botrytis cinerea and Pseudomonas syringae pv. phaseolicola susceptibility and Root length 1') from Arabidopsis thaliana
Analysis of a Pathogen and Circadian Clock controlled Arabidopsis gene, PCC1, revealed five paralogs in the genome of this model plant on chromosomes 1, 2 and 3. The expression pattern of these five members of the PCC1 super-family under various conditions and after particular stimuli was followed …
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Establishment of a systematised approach for the development of novel diagnostics and therapeutics in the field of biotechnology
The aim of the first part of this thesis was to generate an antibody against Nonylphenol for later use in biofilters for the elimination of Nonylphenol from waste water. For this purpose mice were immunised following different strategies. The immunisation according to High Zone Tolerisation led to …
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Struktur- und Funktionsuntersuchungen am humanen Interleukin-11-Rezeptorkomplex
Interleukin-11 (IL-11) belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, which all share the glycoprotein gp130 as a signal transducing receptor component. IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) alpha-subunit (IL-11R-alpha). The third …
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Verfahren zur Herstellung gefriergetrockneter Kollagenschwämme mit definierter Porenstruktur
Collagen sponges are used in many medical application as implant or as biomaterial in the field of tissue engineering. It is commonly assumed that the inner three-dimensional structure of the collagen sponges influences cell behaviour. Until now, this influence could not be investigated …
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Mikrofluidische Strukturen für biochemische Analysen
The immunoassay is an important serological detection method for biochemical active materials (antigens / anti-bodies). By designing appropriate micro fluidic structures to perform the classic process steps of an immunoassay it can be integrated on a microfluidic chip. The reagents are transported …
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Interaktionen von Mikroorganismen und Granulozyten mit Polymer-Oberflächen
Due to an increasing number of biomaterials for clinical applications and more complicated mechanical requirements, there is a growing number of new polymers and polymer modifications. Whereas the physical properties can be varied without great difficulties, biocompatibility is often the limiting …
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Representation of depth in neural population responses
To perceive the visual world as three-dimensional, the brain has to reconstruct spatial structure from retinal images that are only two-dimensional. This ability is called depth perception, and it relies on a variety of depth cues. Disparity and motion are only two examples of such cues. They were, …
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