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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1660 for “"Biosynthesis"”.
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Stereochemical aspects of virginiamycin biosynthesis: biosynthesis of antibiotic A33853
The biochemical pathways for the formation of the unusual amino acids found in virginiamycin M₁ and A33853 were investigated. Specifically tritiated and carbon 14 labeled serines were incorporated into virginiamycin M₁. (2S)-serine and (2S,3R)-[3-³H] serine were found to be precursors, thus giving …
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Regulation of Galactosylceramide Biosynthesis
An important branchpoint of mammalian sphingolipid metabolism occurs at the step where ceramides are glycosylated to glucosylceramide (GlcCer) versus galactosylceramide (GalCer), which are precursors of all mammalian glycosphingolipids. Relatively few studies have focused on this branchpoint …
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Studies of thiamine biosynthesis
… phosphate (Thz-P). The thiazole moiety is biosynthesised from 1-deoxyxylulose-5-phosphate, tyrosine, and cysteine, and at least six genes are required including thiH, thiG, thiS, and thiF. Whilst in aerobes, the C2-N3 fragment of Thz-P derives from glycine in a reaction catalysed by the …
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Biosynthesis of Selected Antibiotics
The biosynthetic pathway for the novel antibiotics nodusmicin (9) and nargenicin (10) was established as polyketide in origin. Three metabolites previously unreported from Nocardia argetinensis var. Huang (ATCC 31306) were isolated and identified as 18-O-acetylnodusmicin (13), and …
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Biosynthesis of the Streptovaricins
Made available in DSpace on 2014-12-10T23:02:14Z (GMT). No. of bitstreams: 1 7514145.pdf: 3218801 bytes, checksum: 84f62ed263e5d7d4b5a0e5bf655628ea (MD5) Previous issue date: 1975
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Enzymology of Gentamicin Biosynthesis
… involved. The final steps of gentamicin biosynthesis begin at gentamicin X2, the last common intermediate of the C complex. 6'-C-Methylation generates two branches, with analogous reactions happening in both. Candidate genes and enzymes for the steps from the first 6'-C-methylated …
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The biosynthesis of ravidomycin
Ravidomycin is a yellow antitumor antibiotic produced by Streptomyces ravidus. Ravidomycin shows strong antitumor activity against P388 lymphocytic leukemia, the colon 38 tumor, and the CD8Fl mammary tumor. It is also very active against Gram positive bacteria. Biosynthetic studies have shown that …
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Urea Biosynthesis in Chelonian Reptiles
No abstract prepared.
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Mechanistic studies of lanthipeptide biosynthesis
Natural products and natural product derivatives have been the leading source of pharmaceutical compounds since the initial application of modern medicine. To fight the increasing occurrence of drug resistance and to reach the ultimate goal of personalized drugs for treating complicated symptoms, …
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Lysine Biosynthesis in Neurospora Crassa
Made available in DSpace on 2014-12-10T17:37:42Z (GMT). No. of bitstreams: 1 6406167.pdf: 3944497 bytes, checksum: ec6d4ced848a60ce0ade3e25c3923ac3 (MD5) Previous issue date: 1963
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Physiological Studies of Tryptophan Biosynthesis
Made available in DSpace on 2014-12-09T22:04:20Z (GMT). No. of bitstreams: 1 6915374.pdf: 5036251 bytes, checksum: c339ba6a6af713e82a113e157d04e7ed (MD5) Previous issue date: 1969
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Hexosamine Biosynthesis in Leuconostoc Mesenteroides
Made available in DSpace on 2014-12-05T21:45:37Z (GMT). No. of bitstreams: 1 6202953.pdf: 3065636 bytes, checksum: bd6be1585e391bf16f94c0b1bc62cf16 (MD5) Previous issue date: 1962
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Biosynthesis and engineering of lanthipeptides
… conditions. A detailed understanding of the biosynthesis and mode of action could allow engineering of these peptides for better pharmacological properties. In this thesis, biosynthesis of several lanthipeptides belonging to the cinnamycin group of peptides is described, and the biosynthetic …
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Exploring and understanding lantibiotic biosynthesis
… of NisB, the dehydratase involved in the biosynthesis of nisin. NisB requires glutamate, adenosine-5’-triphosphate, Mg2+, and the ribosomal/membrane fraction of bacterial cell extract to dehydrate its substrate peptide NisA. Mutation of 23 highly conserved residues of NisB identified a …
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Stereochemical control in lanthipeptide biosynthesis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Investigating the biosynthesis of fosfazinomycin
… is crafted and installed during fosfazinomycin biosynthesis. The building blocks used to construct natural products are often derived from metabolites coming from central metabolism. Chapter 2 addresses my efforts to ascertain the biosynthetic origins of the N-N bond in fosfazinomycin. I was …
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