Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 542 for “"Biopsies"”.
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A review of transrectal ultrasound guided prostate biopsies is there still a role for finger-guided prostate biopsies?
… and treating this disease. Traditionally needle biopsies of the prostate were performed blindly by digital palpation of the gland per rectum.
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A surgical confocal microlaparoscope for real-time optical biopsies
… may be used to locate unusual regions for guided biopsies. In the long term, the device may be able to supplant traditional biopsies and allow the surgeon to identify early stage cancer in vivo.
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Analysis of Periapical Biopsies Submitted for Histopathological Evaluation: A Retrospective Study
… pathoses. Routine submission of periapical biopsies is required to establish a specific diagnosis <strong>any time</strong> a recoverable amount of tissue can be removed from a periapical surgical site. In addition to dictating further management, histopathologic examination helps to rule …
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A Microfluidic Tissue Array (µFTA) For Personalized Medicine using Tumor Biopsies
… is towards the culture paradigm, using tumor biopsies from cell-derived xenografts (CDX, e.g. MB-MDA-231 and BT 474) and patient-derived xenografts (PDX, e.g. M37 and M156) breast cancer models. As this work was in progress, other labs have also worked on creating a whole tissue culture …
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Label-Free Microfluidic Devices for Single-Cell Analysis and Liquid Biopsies
… machine learning for data processing. Liquid biopsies involve studying cancer cells in patient vascular systems, called circulating tumor cells (CTCs), through blood samples. CTC tests reveal valuable information on patient prognosis, diagnosis and can aide therapy selection in a minimally …
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ISOLATION AND CULTURE OF FIBROBLASTS FROM ENDOSCOPIC DUODENAL BIOPSIES OF CELIAC PATIENTS
… primary fibroblasts from endoscopic duodenal biopsies of celiac and non-celiac subjects, to analyze their growth patterns and the morphometric characteristics. Patients and Methods. 60 duodenal bioptic specimens from 20 celiac patients and 114 from 38 non-celiac subjects were mechanically …
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Genetic Evolution and Prognostic Determinants of Pancreatic Cancer On Longitudinal Liquid Biopsies
… For this reason, we aim to use so called “liquid biopsies” in the form of circulating nucleic acids and exosomes as a strategy that is amenable to longitudinal, relatively non-invasive sampling. Circulating tumor DNA and circulating exosomes contain genetic cargo representative of the neoplastic …
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Development of microfluidic devices to maintain and interrogate tissue biopsies - biomedical applications
Currently most cell-based methodologies in microfluidic systems utilize homogeneous or heterogeneous cell populations. However, these systems do not present an accurate representation of in vivo dynamics. A microfluidic based experimental methodology has been developed that offers a biomimetic …
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Renal allograft biopsies at Groote Schuur Hospital: a histopathologic descriptive study with molecular insights
Background: Kidney transplantation is the definitive treatment for end-stage kidney disease. Immune-mediated rejection remains a barrier to success. It is diagnosed through the Banff classification, which incorporates histopathology and biomarkers (C4d/donor specific antibodies (DSA)). In …
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Oncoproteomic applications for detection of breast cancer. Proteomic profiling of breast cancer models and biopsies
… cancer cell lines and stage-specific liquid biopsies (nipple aspirate fluid [NAF], plasma samples) to identify disease and phenotype specific signature. An 8-plex iTRAQ quantification strategy was employed to compare proteomic profiles of a range of breast cancer and ‘normal-like’ cell lines …
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Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of needle biopsies
Needle biopsy (NB) is known as a standard clinical procedure for cancer diagnosis in humans and companion animals. There has been a rising concern about the time cost of the conventional histopathological assessment of the NB specimens. Therefore, a real-time point-of-procedure assessment method of …
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Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period
… studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, histological findings and procedural complications. Objectives: To ascertain the role of liver biopsy in the evaluation of patients with liver diseases at Red Cross War …
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Clinico-pathological features of repeat renal biopsies in patients with lupus nephritis at Groote Schuur Hospital, Cape Town
Background: Repeat renal biopsies in patients with lupus nephritis (LN) are usually done to guide treatment or to establish disease chronicity. Their value is not clear from available literature. There is also no available data in Africa to guide clinicians. Methods: This was a retrospective study …
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Detection of Cell-free Tumor DNA in Liquid Biopsies of Dogs with B cell Lymphoma: A Biomarker Discovery
Lymphoma is a common hematopoietic malignancy in canines. Current diagnostic techniques to diagnose lymphoma are often invasive and expensive. Additionally, tumor heterogeneity complicates the accurate classification and diagnosis of specific subtypes, hindering the development of targeted therapy …
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Factors influencing pneumothorax rates of transthoracic CT-guided lung biopsies in a Tertiary centre in Cape Town, South Africa
… rate of transthoracic CT-guided lung biopsies of focal lung lesions at Groote Schuur Hospital, and assess how procedural, patient and lesion factors influence these results. Methods: A retrospective review of 237 CT-guided lung biopsies performed over a 24-month period. Patient's CT, …
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Identification of biomarkers with clinical utility in liquid and tissue biopsies of patients with head and neck squamous cell carcinomas
Los carcinomas escamosos de cabeza y cuello (CECC) comprenden un complejo y heterogéneo grupo de neoplasias que, a su vez, presentan una amplia diversidad de alteraciones genéticas y moleculares. Sin embargo, dichas características ofrecen grandes oportunidades para identificar potenciales …
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Development of micro fluidic based devices for studying tumour biology and evaluating treatment response in head and neck cancer biopsies
… of the work in this thesis was to maintain small biopsies of tumour in a physiological state, more comparable to the in vivo environment than traditional tissue culture techniques, for up to 9 days. This recreation of the ‘tumour microenvironment’ in vitro provided a platform for the testing of …
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Complications of percutaneous native kidney biopsies in adults in low and middle-income countries: A Systematic review and meta-analysis
… Results: 35 studies reporting on 18,456 kidney biopsies met the inclusion criteria. The overall rate of kidney biopsy complications was 14.0% (95% CI 10.0-18.0%).Major complications occurred in 1.3% (95% CI 0.8 – 2.4%) whilst minor complications were 10.9% (95% CI 0.07.4-14.9%). LMIC in Europe …
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Integrative Cancer Immunogenomic Analysis of Serial Melanoma Biopsies Reveals Correlates of Response and Resistance to Sequential Ctla-4 and Pd-1 Blockade Treatment
… immunogenomic profile analyses from serial tumor biopsies.</p> <p>From immune profiling (12 marker immunohistochemistry and NanoString Gene Expression Profiling), we found that adaptive immune signatures in tumor biopsies obtained from early on-treatment time points are predictive of response to …
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