Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Bioprosthetic"”.
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Bioprosthetic heart valves : ultrastructure and calcification
… the ultrastructural preservation of the bioprosthetic tissue. 3) Eventually, the influence of improved ultrastructural preservation on calcific degeneration was evaluated under in vivo conditions in the non-human primate and the rat model. Results: The comparison of the four most commonly …
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A Computational Model for Design Optimization of Bioprosthetic Heart Valves
… flow in the heart. Design and development of bioprosthetic heart valves has been a major focus of research in the field of cardiovascular engineering as they are a better replacement for natural diseased valves than mechanical heart valves. Their lower risks of thrombogenicity and superior …
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Mitigation of the inflammatory response to bioprosthetic heart valve tissue through antigen-directed masking
… directed to characterise the immune response to bioprosthetic heart valves in patients as well as in animal models. The study further demonstrated that the glutaraldehyde concentration applied to commercial heart valves is insufficient to mask the antigenicity of the tissue, therefore an method …
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Fully Coupled Fluid Structure Interaction Simulation of Bioprosthetic Heart Valves: A Numerical and Experimental Analysis
… is essential to consider accurate properties of bioprosthetic heart valves (BHVs), such as density and mechanical properties. Previous computational studies assumed (bovine pericardium) BP used in BHVs density was comparable to water or blood. Yet, BP is subjected to multiple treatments like …
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Early calcification patterns of bioprosthetic aortic tissue : a comparison of amino versus carboxyl group and combination cross-linked tissue
Includes bibliographical references.
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Novel positron emission tomography applications for imaging cardiovascular disease activity
… coronary atherosclerosis, aortic stenosis and bioprosthetic valve disease, offering a marker of vascular injury and disease activity in each condition studied. At the moment, we lack reliable and reproducible methods for predicting myocardial infarction in patients with established coronary …
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Hemodynamic Flow Characterization of St. Jude Medical Bileaflet Mechanical and Bioprosthetic Heart Valve Prostheses in a Left Ventricular Model via Digital Particle Image Velocimetry
The performance of the heart after a valve replacement operation will greatly depend on the flow character downstream the mitral valve thus a better understanding of the flow character is essential. Most in vitro studies of the flow downstream of a MHV have been conducted with the valve in the …
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Characterisation of the cross-linking and calcification associated with glutaraldehyde-treated cardic bioprostheses.
… each year. Valve replacement with mechanical or bioprosthetic devices enhances patient survival and quality of life. Bioprosthetic valves have a significant advantage over mechanical valves: they do not necessarily require long-term anticoagulant therapy however, dystrophic calcification can lead …
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Predicting Transcatheter Aortic Valve Leaflet Thrombosis Risk Using Pre-Procedural Computed Tomography Angiogram and Computational Modeling
… stenosed aortic valve is usually replaced with a bioprosthetic valve either via open-heart surgery or transcatheter aortic valve replacement (TAVR), a less invasive procedure that has shown similar long-term outcomes as surgery. However, there have been reported instances of complications …
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Hemodynamic Assessment of Y-Incision Aortic Root Enlargement Using Computational Simulations
… the hemodynamics in the aortic root and bioprosthetic valve regions after aortic root enlargement. Results indicate the velocity magnitude at the sinus regions of a patient who underwent the Yang procedure was slower, indicating risks of flow stasis and thrombosis. Simulation results …
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Polymeric Transcatheter Heart Valves
… only treatment currently available. Commercial bioprosthetic valves (surgical and transcatheter) suffer from calcification and decreased durability, especially when implanted into younger patients, while mechanical surgical valves require life-long anticoagulation. Polymeric transcatheter aortic …
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The Green Lane Valve: a Novel Decellularised Heart Valve
… outperforms standard, glutaraldehyde-treated bioprosthetic valves, in vivo, remains to be developed. Methods: A systematic review and meta-analysis was undertaken of the clinical performance of decellularised heart valves implanted in either outflow tract position, compared with standard …
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A novel polymeric prosthetic heart valve: design, manufacture, and testing
… also having lifelong durability, which current bioprosthetic heart valves are not able to achieve. Inspired by the anisotropic architecture of collagen in the natural valve, a shortlist of polystyrene based block copolymers (BCPs), which can be processed to yield mechanically anisotropic …
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Hybrid Electrospun Transcatheter Aortic Heart Valves for Tissue Engineering Applications
Bioprosthetic and mechanical heart valves are suboptimal due to both calcific degeneration and the need for lifelong anticoagulation treatment. Tissue engineering (TE) has the potential to overcome these and other shortcomings by providing viable valves capable of growth, remodelling, and repair. …
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