Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Bioprocesses"”.
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Perturbation-based Control of Industrial Fed-batch Bioprocesses
… control of industrial-scale microbial fed-batch bioprocesses. Its focus is therefore on methods which are easy to implement in an industrial setting, which gives certain limitations on sensors, actuators and control systems. The main part of the work in the thesis concerns control of the …
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Integrated microbioreactors for rapid screening and analysis of bioprocesses
(cont.) strains to characterize the bioreactor environment. The ability to reproducibly sacrifice microbioreactors mid-run is exploited to demonstrate the feasibility of linking microbioreactors to genome-wide expression studies using DNA microarrays. The potential of the microbioreactor for …
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Machine vision microscopy as an on-line sensor for bioprocesses
A machine vision microscopy system (combination of video hardware and software and microscope for automated identification) was developed for classifying and counting microscopic objects in a Bacillus thuringiensis (Bt) fermentation. Image morphology properties consisting of area, perimeter, major …
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Simulation, sensitivity analysis, and optimization of bioprocesses using dynamic flux balance analysis
… component of natural ecosystems and industrial bioprocesses. In natural ecosystems, these communities can present abrupt and surprising responses to perturbations, which can have important consequences. For example, climate change can influence drastically the composition of microbial …
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NEW BIOCATALYTIC PLATFORMS FOR THE SYNTHESIS OF HIGHLY VALUABLE COMPOUNDS THROUGH INTENSIFIED BIOPROCESSES
This PhD thesis is focused on developing and optimising biocatalytic platforms to obtain high valuable products in a more sustainable way compared to classical chemical synthesis, focusing the research on alcohols oxidation, synthesis of nitriles and de-glycosylation of glycosides. A particular …
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Engineering antimicrobial strains of saccharomyces cerevisiae as industrial platform for non-sterile bioprocesses
Microbial contamination is a major challenge in fuel ethanol facilities, especially during the fermentation stage. Bacterial contaminants compete with yeast for fermentable sugars and nutrients, which obstructs starch to ethanol conversion. This leads to a reduction in ethanol yield. At large …
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A generic approach to environmental assessment of microbial bioprocesses through life cycle assessment (LCA)
… environmental advantages of industrial scale bioprocesses over chemical processes remain a discussion point owing to limited objective analysis. Studies to date are often limited to energy or global warming considerations with little regard for full Life Cycle Assessment (LCA) analyses. This, …
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Biological conversion of alkanes to dicarboxylic acids : an investigation into process challenges and optimisation in hydrocarbon-based bioprocesses
… transfer to the organism in hydrocarbon-based bioprocesses has been regarded as especially challenging because of the absence of oxygen in the hydrocarbon backbone. In contrast to carbohydrate-based bioprocesses in which the carbohydrate itself supplies about half of the oxygen, the metabolic …
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Integrated microbioreactor arrays for high-throughput experimentation
Bioprocesses with microbial cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve the complicated interaction between the genetics of the microorganisms and …
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Extension and verification of the PWM_SA model to incorporate SANI-specific bioprocesses using experimental data from the Hong Kong SANI saline sewage treatment pilot plant.
… Africa (PWM_SA) by integrating SANI-specific bioprocesses to evaluate its applicability in ad dressing these challenges. The study's primary objectives included adapting the PWM_SA model to incorporate sulfate reduction, autotrophic denitrification, and nitrification processes characteristic …
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Online Raman spectroscopy for bioprocess monitoring
Online monitoring of bioprocesses is essential to expanding the potential of biotechnology. In this thesis, a system to estimate concentrations of chemical components of an Escherichia Coli fermentation growth medium via a remote fiber-optic Raman spectroscopy probe was studied in depth. The system …
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Method development for the characterization of intrinsic and extant kinetic parameters in microalgal cultures
Algal bioprocesses for wastewater treatment have the potential to simultaneously recover nitrogen and phosphorous while also producing feedstocks for bioenergy and bioproducts. In order to develop reliable treatment processes for water resource recovery facilities, however, it is critical that we …
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Global transcriptional analysis of an Escherichia coli recombinant protein process during hypoxia and hyperoxia
… strategies for increasing the resistance of bioprocesses to the damaging effects of oxygen and recombinant protein production.
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On the Effectiveness and Challenges of Electrosynthesis Strategies in Escherichia coli
Conventional bioprocesses that aim to convert CO2 to fuels and chemicals do so through a supply chain that begins with agricultural products such as corn, intermediaries like dextrose, and eventually produce chemicals by fermentation. However, it has long been desired that bioprocesses be …
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Disruption of microorganisms due to agitation in slurries of fine particles
… may ensue. The presence of particulates in bioprocesses, in the form of solid substrates or support systems for attached growth, further complicate the hydrodynamic conditions. The knowledge of the effect of particulates on microorganisms is an important priority.
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Centrifugal recovery of embryonic stem cells for regenerative medicine bioprocessing
… is crucial that economical, robust and scalable bioprocesses be established. Because bioprocesses irrevocably define the safety and efficacy of any biologically derived product, an understanding of the the impact of the engineering environment on ES cells is sought. This thesis uses murine ES …
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Characterization of Extremophilic Bacteria for Potential in the Biofuel and Bioprocess Industries
Industrial bioprocesses are constrained by the availability of microbes that are optimized for harsh bioprocess conditions. Over 500 soil and sediment samples collected from 77 saline and/or thermal sites in the continental United States, Hawaii, and Puerto Rico were used to inoculate fermentations …
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Designing and optimizing tandem bio- and chemo-catalyzed cascade reactions to access industrially relevant chemicals in mild, aqueous conditions
… However, the scope of products accessible from bioprocesses is limited. In recent years, a compelling complementary strategy has emerged: merging non-enzymatic chemistry with microbial metabolism to direct flux and deliver products that would be challenging to synthesize through biosynthetic …
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Data-driven Dynamic Control Scheme for Antibody Producing CHO Cell Cultures in Fed-batch
… non-linearity and uncertainties associated with bioprocesses challenge the ability of traditional controllers to deliver satisfactory performance, thereby creating a need for advanced model based control strategies for efficient bioprocess control. Unlike the chemical or traditional …
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