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Showing 1 to 20 of 63 for “"Biophysics--Medical"”.
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
Human rhinovirus (HRV)-induced wheezing illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR …
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Magnetic Resonance Imaging (Mri) Studies of the Rat Olfactory System
In vivo MR-imaging was also applied to study effects of neonatal, unilateral olfactory denervation on postnatal olfactory bulb growth. The in vivo imaging data were used to quantify the reduction in laminar volumes of the denervated bulb, compared to contralateral control bulb, unoperated normal …
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Cerebral Hemodynamics and Its Oxygenation: Study of Their Baseline and Spontaneous Oscillation
Near infrared spectroscopy (NIBS) has been used for determination of tissue optical properties. This technique has been especially useful for in vivo monitoring of hemodynamics and oxygen saturation in tissue. For this work, I have developed a large-ranged multidistance probe for NIBS, which allows …
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Heterogeneity of the Bc1 Complex Subunits and Qo Site Occupants From Rhodobacter Sphaeroides
For decades there has only been anecdotal data regarding how difficult it is to crystallize membrane proteins but these facts are never rigorously evaluated, because virtually no one can report all the reasons why membrane proteins do not crystallize easily. Trials to crystallize bc1 complex from …
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Novel MRI Contrast Agents Based on Functional DNA and Nanomaterial Conjugates for Biomedical Applications
Finally, we have demonstrated that the fluorescein encapsulated one micron liposomes can be used to detect inorganic mercury in water. At the same time, we have shown that chelators of inorganic mercury can be encapsulated in liposomes and released upon mercury detection.
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Regulation of Sodium Transport in A6 Epithelia by Prostaglandin E(2)
A pulse method of blocker-induced noise analysis was used to study the time-dependent changes of channel density (NT), channel open probability (Po) and single-channel current (iNa) of apical membrane epithelial Na + channels (ENaCs) in A6 epithelia in response to 1 muM PGE 2 added to the …
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Characterization of Monomeric Human Cytochrome P450 3A4 and Cytochrome P450 Reductase in Nanoscale Phospholipid Bilayer Discs
The differences that cause the conformational heterogeneity of CYP3A4 in other solubilization systems have complicated the complete biophysical characterization in comparison to similar soluble bacterial counterparts. The use of a discrete soluble nanoscale phospholipid bilayer system with an …
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Rotational Dynamics and Proton Relaxation of MRI Paramagnetic Contrast Agents
Rotational dynamics play an important role in determining the relaxation characteristics of paramagnetic contrast agents (PCA's) used in magnetic resonance imaging. In this work, a methodology employing continuous wave electron paramagnetic resonance spectroscopy has been developed and established …
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Magnetic Resonance Imaging by Populations in the Presence of Molecular Diffusion
This work makes extensive use of relaxation theories (chapters 2 through 4) and numerical simulations (chapters 3 and 4) to delineate the physical basis of MRI by populations and predict enhancements of performance. Chapters 3 and 4 predict the resolution of the method for ideal spatial geometries. …
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Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
By attaching the fluorophore directly onto the ligand-binding domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and …
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Quantitative Measurement of Velocity and Dispersion via Magnetic Resonance Imaging
Three pressure-driven flows of increasing complexity were examined, including flow through a water-saturated bed of randomly packed spheres, a Taylor-Couette-Poiseuille flow reactor, and the interstitial space between the blades of a rotating partitioned pipe mixer. Key findings show that a …
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The Role of Phase Inversion in the Drug Release Kinetics of Injectable Polymer Solutions
Phase inversion is a process in which a concentrated polymer solution is converted into a solid gel network with desirable end-use properties. In this thesis, studies of the role nonsolvent induced phase inversion plays in the protein release kinetics of injectable drug delivery devices are …
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Scale-Driven Image Decomposition With Applications to Recognition, Registration, and Segmentation
… computer vision, public security, surveillance, medical image analysis, and other related fields.
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Magnetic Resonance Microscopy: 1. Four-Dimensional Spectral-Spatial Imaging. 2. Diffusional Effects in Magnetic Resonance Microscopy
DESIRE (Diffusionally-Enhanced Signal Intensity and REsolution) is a new method for nuclear magnetic resonance (NMR) microscopy which couples a spatially localized region of saturated magnetization to the surrounding medium via translational diffusion of spins, resulting in amplification of the …
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Effect of Nitroxides and Molecular Oxygen on Proton Relaxation Rates in Aqueous Systems and in Lipids
A fundamental investigation of the potential of nitroxides and O$\sb2$ for enhancement of magnetic resonance imaging (MRI) contrast in vivo is presented. The effect of these species on proton relaxation in both aqueous systems and in lipids is studied. The basic experimental approach for this study …
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Absolute Concentration Determination of Phosphorus Metabolites in the Langendorff-Perfused Rabbit Heart by Phosphorus-31 Nuclear Magnetic Resonance (Quantification, Metabolism, Intact Tissue, Nmr)
The concentrations of mobile high energy phosphorus metabolites and intracellular pH of Langendorff-perfused rabbit heart have been determined under control and reduced flow conditions. Absolute concentration determination was accomplished by Lorentzian lineshape analysis after development of …
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Dose-Effect Relationships for Ultrasound Irradiation of Brain Tissue
Made available in DSpace on 2014-12-14T05:40:44Z (GMT). No. of bitstreams: 1 7915373.pdf: 3243153 bytes, checksum: 2c7e6604619722641892532e7953509e (MD5) Previous issue date: 1979
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Studies on the cone pigment, iodopsin
I. Three kinds of monoclonal antibodies have been found against iodopsin and other cone pigments in chicken retina: (1) specifically against iodopsin (cell line of 7D3); (2) against iodopsin and another cone pigment (cell lines of 2D4, 4G2, and 5E3); and (3) against iodopsin and other three cone …
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Cerebrovascular and Ventilatory Function in Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a disease primarily affecting the pulmonary system, most commonly resulting from prolonged exposure to cigarette smoke. While systemic respiratory disturbances in COPD are apparent, the chemical regulation within the brainstem and at the carotid …
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Social Workers' Experience of Moral Distress
According to Jameton (1985), “moral distress arises when one knows the right thing to do, but institutional constraints make it nearly impossible to pursue the right course of action” (as cited in Pendry, 2007, p.1). The issue of nurses and moral distress has been studied extensively; however, …
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