Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 293 for “"Biophysics, General"”.
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OXYGEN-17 NUCLEAR MAGNETIC RESONANCE OF GLYCINE, ALANINE, DIPEPTIDES AND MELANOCYTE INHIBITING FACTOR (NMR).
OXYGEN-17 NUCLEAR MAGNETIC RESONANCE OF GLYCINE, ALANINE, DIPEPTIDES AND MELANOCYTE INHIBITING FACTOR (NMR).
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Mathematical model of the sprint relay race.
The purpose of this investigation was to develop and validate mathematical models of the sprint relay race. Two approaches, a classical exponential approach and a "new" polynomial approach, were chosen for implementation. Archival film of a 100 m sprint was used to gather displacement data for the …
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Effects of Immobilization Matrices and Protein Orientation on Biomolecular Recognition at Solid-Liquid Interfaces
We then investigated the dependence of protein orientation on the forces between immobilized proteins and soluble ligands. Oriented cytochrome b5 monolayers were constructed on supported lipid membranes using a site-selective immobilization method. The orientation of the immobilized cytochrome b5 …
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Microviscometric Analysis of Microvascular Hemodynamics in Vivo
… the equation for conservation of momentum for a general incompressible non-Newtonian fluid, subject to the velocity profile extracted from the mu-PIV data, to provide viscosity, shear-rate, and shear-stress profiles as well as the axial pressure gradient, volume flow, local and apparent blood …
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Characterization of Protein Interactions in Eye Lens Crystallin Proteins and Crystallization
The central theme of this research is to understand how protein interactions alter the state of aggregation and the characterization of these interactions through light scattering properties of dense suspensions. One context where protein interactions have an impact on the state of aggregation is …
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Multi Scale Fluorescence Studies: The Spinning Disk Confocal Fluorescence Lifetime Imaging Microscopy & Single Molecule Nano-Metronome & Single Molecule Study of Tetramethyrhodamine -Dna Interaction
The final part presents the single molecule study on a behavior of a popular fluorescent dye called Tetramethylrhodamine (TMR) attached to the end of DNA oligomer. The study reveals that in the absence of any biological activities of DNA, the fluorescence emission of TMR undergoes multiple slow …
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Structure, Assembly, and Maturation of High -Density Lipoproteins
High-density lipoproteins (HDL) are protein-lipid particles that are involved in the transport of cholesterol in the blood. They are of great importance in the treatment of coronary heart disease as low levels of HDLs are a known risk factor for the development of arteriosclerosis. Little is known …
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Development & Application of Fluorescence Spectroscopy & Fluorescence Lifetime Imaging to Biology & Medicine
The dissertation is concerned with biophysical applications of Forster resonance energy transfer (FRET) and development and application of fluorescence lifetime-resolved imaging microscopy (FLIM). It includes work to extend the FRET and FLIM methods for studying microsecond reaction kinetics. The …
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Molecular Basis of Cell Adhesion Mechanics
Adhesive interactions between cells in multicellular organisms play a significant role in the development and maintenance of compact tissue structures. Cell adhesion depends on specialized adhesion molecules on the cell surfaces. Recent developments studying physical and chemical properties of the …
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The Calcium Channel Gamma6 Subunit Analysis of Function and Determination of a Sequence Motif Critical for Its Effect
The auxiliary gamma6 subunit of voltage dependent calcium channels is known to decrease calcium current density when co-expressed with the pore forming Cav3.1 subunit. In this study, I showed that Cav3.1 calcium channels are a major pathway for calcium influx at resting membrane potential, and that …
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A Dynamical Analysis of Changing Direction During Walking
A dynamic analysis of the three dimensional (3-D) kinematic and kinetic characteristics of changing direction during walking was conducted which included examination of: the body segment contributions to the angular momentum about the center of mass of the whole body, coordination and control of …
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Structure and Function of a Cytochrome P450 From Synechocystis Sp. PCC 6803
"Three decades ago it was thought that there were but a few cytochrome P450s and their functional landscape was relatively limited. We now know that there are over 6,000 P450 gene products, which display a variety of activities and provide interesting and crucial metabolic transformations. The …
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Two -Photon Dual Channel Fluctuation Correlation Spectroscopy: Theory and Application
Fluctuation correlation spectroscopy (FCS) is a non-perturbative method used to gain molecular information from stochastic processes such as Brownian motion (Magde, Elson et al. 1972). Dual channel FCS allows for the investigation of static (molecular associations) and kinetic (protein dynamics) …
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The Energy Landscape of Associative Memory Energy Functions and Their Application to Ab Initio Protein Structure Prediction
The ability to predict the structure of a protein from its amino acid sequence is one of the major practical benefits that it is hoped will result from a greater understanding of the physics of protein folding. For sequences for which a highly homologous sequence with known structure is available, …
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Dynamics of Hairpin Ribozyme
This thesis research uses single molecule spectroscopy to study the dynamics of hairpin ribozyme---an enzymatic RNA molecule capable of cleaving phosphodiester linkage. RNA controls key processes of gene expression. Ribozymes can catalytically edit precursor RNA message transcribed from DNA, the …
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Proton Translocation in the Bacteriorhodopsin Photocycle
From the above studies, we concluded that at low pH, the released proton is from the PRC as at neutral pH, but is delayed until the O to BR transition. The O to BR transition is rate-limited by the deprotonation of the PRC.
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Phosphorus-31 NMR Spectroscopy of Parasitic Protozoa
31P NMR spectra have been obtained of various parasitic protozoa including Trypanosoma cruzi, Leishmania major, Trypanosoma brucei, Plasmodium berghei, Toxoplasma gondii, and Cryptosporidium parvum. The unifying features of solution-state 31P NMR spectra of acid extracts of these parasites were …
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An Evolutionary Computation Model of Intracellular Signaling Networks
We use evolutionary computation (EC) methods to simulate the evolution of a particular class of intracellular signaling networks. This class of signaling networks mimics the cellular state transition (or mode switch) in a living cell in response to a specific number of prerequisites. Two different …
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A Survey of Beta-Sheet Folding: WW Domains With Zinc Fingers and Membrane Peptides
This work describes the present state of folding research involving small, fast-folding protein systems. By perturbing a WW domain sequence with side-chain mutations, truncations, amide-to-ester exchanges, and loop rearrangements we find that loop structures can dictate the folding dynamics of this …
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Spectroscopic and Electrochemical Analysis of the Rieske Iron-Sulfur Protein of the Rhodobacter Sphaeroides Bc1 Complex
The Rieske iron-sulfur protein (ISP) subunit of Rhodobacter sphaeroides cytochrome bc1 complex was isolated and then investigated using molecular spectroscopies (high-resolution electron paramagnetic resonance and resonance Raman), protein-film voltammetry, and x-ray crystallography. Major …
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