Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Biophysical interaction"”.
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Genetic selection of cyclic peptide G-quadruplex ligands
… artificially select ligands with the strongest biophysical interaction. With optimisation of the phage display selection process and motif analysis, a bicyclic peptide lead (ckit1bpep4) was generated with G4 binding properties comparable to those of the most utilised small molecule ligands. …
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The pattern and functional consequence of Killer Immunoglobulin-like Receptor expression on T cells.
… activating and inhibitory KIRs and studied the biophysical interaction of these proteins with HLA-C molecules. I saw some evidence that KIR2DS2 binds to the HLA-C group 1 allele HLA-Cw*0702, supporting the idea that HLA-C alleles are a true ligand for stimulatory KIRs. I then went on to make a …
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Engineered hydrogels for tracking cell signaling from the outside-in
… demonstrate a platform to study how signals from biophysical interaction in extracellular space are propagated into the cell nucleus to influence epigenetics and use this platform to further understand the process of reprogramming. In chapter 2, we present an in vitro system to decouple the effect …
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Development of a novel cell traction force transducer based on cholesteryl ester liquid crystals. Characterisation, quantification and evaluation of a cholesteryl ester liquid crystal based single cell force transducer system.
… indentation, and micro-tensile tests. The interactions of LLC with cells were studied by using cell viability studies, cytochemical treatments, widefield surface plasmon resonance (WSPR) microscopy and various immuno-staining techniques. The results show that LLC is thermally stable (0 - 50 …
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Seabird foraging in dynamic oceanographic features
… This research demonstrated the importance of biophysical interactions in creating phalarope habitat, and characterized red-necked phalarope habitat in both space and time. In Onslow Bay, I investigated the effects of Gulf Stream fronts and eddies on the abundance and distribution of seabirds …