Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Biophysical Modeling"”.
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Biophysical modeling of hemodynamic-based neuroimaging techniques
… on multi-distance measurements and state-space modeling was developed and further optimized to remove systemic physiological oscillations contaminating the NIRS signal. Furthermore, the cortical and pial contributions to the NIRS signal were quantified using a new multimodal regression analysis. …
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Statistical and biophysical modeling of binaural interaction in the lateral superior olive
… encoded remain uncertain. This work develops a biophysical model of the LSO network capable of simulating LSO responses to acoustically realistic stimuli. Our LSO network simulations demonstrate the extreme sensitivity of the LSO transient response to time delays caused by both ILDs and ITDs. …
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Radiation biophysical modeling of the FLASH effect: from mechanistic understanding towards clinical endpoint prediction
… action. Development of a multiscale radiation biophysical model for ultra-high dose rate (UHDR) investigations The first part of this study focused on the conception, realization, implementation, and validation of a multiscale stochastic radiobiological model for the study of the FLASH effect, …
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Hemodynamics Due to Calf Muscle Activity-Biophysical Modeling and Experiments Using Frequency Domain Near Infrared Spectroscopy in Healthy Humans
… was investigated based on computational flow modeling in blood vessels. Computational blood flow modeling involves simulations of the muscle–fluid–structure interactions (FSIs). We further postulate that an improvement in blood flow, e.g. assisted with FES, is beneficial for the vessel walls …
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Investigating mechanisms of biophysical diversity between phasic and tonic motor neurons
… diversity in core neuronal properties (intrinsic biophysical and synaptic properties), which are the building blocks of brain function and computation. Despite the central role of these properties in brain function, the underlying molecular and biophysical mechanisms which generate this diversity …
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Constraints on the adaptive potential of ectotherms to climate change
… surveys, laboratory metabolic measurements, and biophysical simulations, I find that COLS acts as a potent selective agent, particularly in warmer, low-elevation environments. Selection favors individuals with highly sensitive metabolic reaction norms but low metabolic baselines, a strategy that …
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Impact of Noise and Spike Initiation Properties on the Encoding and Transmission of Neural Information
… to inputs with fast kinetics. Together with biophysical modeling, my findings demonstrate that spike initiation properties in each part of the neuron are well matched to the signals normally processed in that neuronal compartment. I then investigated how background synaptic activity (noise) …
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Novel applications and methods for the computer-aided understanding and design of enzyme activity
… of enzyme activity. In the first part. we apply biophysical modeling approaches in order to design non-native substrate specificity in a key enzymatic step (the thiolase-catalyzed condensation of two acyl-CoA substrates) of an industrially useful de novo metabolic pathway. We present a …
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Multiscale Modeling of Genome Organization: Bridging Polymer Physics, Molecular Dynamics, and AI
… temporal resolution. Our approaches integrate biophysical modeling and generative artificial intelligence to address complementary aspects of nuclear architecture. In Chapter 1, we provide an overview of the hierarchical organization of the genome and discuss emerging principles that govern …
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Mechanistic modeling and systems analysis across biological scales, from single cells and regulatory networks to microbial communities
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms