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Showing 1 to 13 of 13 for “"Biopharmaceutics"”.
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The Design and Characterization of a Multiple Pinhole Collimator and Its Applications in Biopharmaceutics
A 4-pinhole collimator was designed to image small objects and its characteristics were studied. The field of view formed by this collimator was a conically-tipped pyramid with a minimum object distance of 3 cm. The line-spread function at 8 cm from the collimator had a full-width-half-maximum of …
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Solid Dispersions in Medium-Insoluble Hydrogels for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
… carriers coupled with the Physiologically based Biopharmaceutics Modeling using GastroPlus® demonstrates that these test carriers can provide similar oral absorption enhancement. Further optimization of ASDs in water-insoluble carriers is still required before they can be employed as alternative …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… and pin-pointing the therapeutic index of novel biopharmaceutics.
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Development of paediatric dosage forms of furosemide using the problem structuring method of morphological analysis
… efficacy, deficiency in safety data (i.e. biopharmaceutics) and the lack of quality information such as palatability and acceptability data in children. To counteract this deficiency bespoke, unlicensed formulations are formulated by contract manufacturers, hospitals and dispensing …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
… etc.</p> <p>Chapter 1 is an introduction into biopharmaceutics classification system (BCS) and novel drug solubilization techniques. It provides a brief history of the BCS and its application in drug development. It also looks into the recent poorly water soluble drugs approved by the Food and …
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DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS
… Class-II drugs according to the FDA adopted Biopharmaceutics Classification Scheme. The unique features of the hydrating CR matrix system consisting of amorphous drug dispersion that provides supersaturation and probable mechanisms to inhibit precipitation are investigated. SDD-loaded CR …
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Particle engineering via surface modification during micronization for pharmaceutical applications
Improving the dissolution rate of Biopharmaceutics Classification System (BCS) class II drugs is an important research area. Micronization which can increase the specific surface area is a promising method to improve the dissolution rate. Micronization alone, however, can lead to downstream …
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Using an In Vitro-In Vivo Correlation for the ‘Bioequivalence by Design’ Development of an Immediate Release Carbamazepine Product
… low solubility) according to the FDA’s biopharmaceutics classification system (BCS). As such, this compound is identified within the FDA’s scale-up and post-approval change guidance as possessing elevated risk for biononequivalence when changes are imposed to its formulation and/or …
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CHITOSAN PARTICLES FOR THE CONTROLLED RELEASE OF PROTEINS
… of chitosan particles in biomedicine and biopharmaceutics. Objective of this Thesis This thesis is aimed to prepare chitosan micro or nanoparticles to delivery proteins. What are the questions this thesis attempted to solve? 1) What are the proper preparation conditions of chitosan micro …
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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents
… The study was also conducted to characterize the biopharmaceutics and pre-clinical pharmacokinetics of the lead QA amide analog, KZ-41. Rats (n=6/group) received a dose of either an i.v. or p.o. dose (10 mg/kg) of KZ-41. Pharmacokinetic parameters were determined from concentration - time profiles …
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Harnessing the manufacturing power of the plant system : production of recombinant human interleukin-2 in Nicotiana benthamiana
Various expression systems are employed for the mass production of recombinant proteins to be used for pharmaceutical, diagnostic and industrial purposes. In this thesis, I have explored the feasibility of producing recombinant human interleukin-2 (IL-2) in the green tissues of transgenic Nicotiana …
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Viral Factors Influencing Early Infection Events During Ex-Vivo KSHV Infection
<p>The enigma of Kaposi Sarcoma Herpes Virus infection, and its persistence despite a quarter century of research on the virus, has given rise to an immediate need for addressing fundamental questions about basic immunology and virology knowledge regarding this virus. Kaposi Sarcoma Herpes Virus …
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Regulation of Novel Biomedical Technologies
This dissertation is the compilation of three separate works of research revolving around the theme of regulation of biomedical technologies that are either emerging or that have undergone significant developments over the past decade or so. Each of these three research works examines a legal …