Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Biopharmaceutical classification system"”.
-
Dissolution kinetics of model api in molten polymer excipients during batch processing
… and high permeability in water) API in Biopharmaceutical Classification System (BCS) could be significantly improved in the body. For readily water-soluble API, HME provides a new approach to produce a controlled release drug system. Hence, pharmaceutical HME is a promising processing …
-
Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer
… for metastatic breast cancer. However, being biopharmaceutical classification system (BCS) class IV agent PTX suffers low solubility, poor permeability and remains a major challenge for efficient delivery specific to the tumor sites. Various formulations of PTX have been developed and approved …
-
Evaluation and enhancement of physical stability of amorphous solid dispersions
… is limited by aqueous solubility (biopharmaceutical classification system (BCS) class II drugs), which is a significant number of recently discovered drug candidates, the improved solubility may lead to enhanced bioavailability.[5-7] Oral absorption of APIs depends on two broad, but …
-
Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
… I. It is classified as a class IΙ drug under the Biopharmaceutical Classification System (BCS) and exhibits a low solubility (aqueous solubility of 9.0 μg/ml) and high permeability (variable oral bioavailability). This study aims to choose a pre-formulation protocol with the best efavirenz …
-
Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… were used as model API’s based on the biopharmaceutical classification system to study the effect of compression force on particle agglomeration during compression and also to study the processes and materials to prevent that agglomeration. The size of furosemide and griseofulvin …
-
Synthesis, Physicochemical And Biopharmaceutical Characterisation Of Pro-Antibiotic Esters; Free Bases Of Ciprofloxacin
Physicochemical and biopharmaceutical properties of drugs play a crucial role in their performance in vivo, especially with respect to oral bioavailability. In the case of antibiotics, poor bioavailability can indirectly encourage antimicrobial resistance from pressure selection resulting from …
-
Synthesis, Physicochemical And Biopharmaceutical Characterisation Of Pro-Antibiotic Esters; Free Bases Of Ciprofloxacin
Physicochemical and biopharmaceutical properties of drugs play a crucial role in their performance in vivo, especially with respect to oral bioavailability. In the case of antibiotics, poor bioavailability can indirectly encourage antimicrobial resistance from pressure selection resulting from …