Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Biopharmaceutic"”.
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Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
… of this project was to characterize the biopharmaceutic and pharmacokinetic characteristics of hesperidin and hesperetin for ocular delivery, especially with respect to the distribution of these compounds to the posterior segment of the eye. Hesperidin and hesperetin were found to be …
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Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery.
<p>Sucrose acetate isobutyrate (SAIB), a randomly substituted sucrose approximating sucrose diacetate hexaisobutyrate, is produced by Eastman Chemical Company for a variety of applications. SAIB is widely used in the food industry as a weighting agent to disperse flavoring oils in primarily …
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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
… development. </p> <p> First, we examined the biopharmaceutic properties and preclinical PK of nitrofuranylamide lead compounds. The first tested lead compound, Lee 562, exhibited a high systemic clearance, short terminal half-life, and low oral bioavailability of 15.9%. These observations were …
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Pharmacokinetic and Pharmacodynamic Studies of a Novel Spectinamide Series of Antituberculosis Agents
… designed to characterize the <em>in vivo</em> biopharmaceutic and pharmacokinetic behavior. Drug uptake studies into <em>Mycobacterium bovis</em> BCG and into J774 murine macrophages were performed to understand reasons for improved activity of spectinamides and to evaluate their potential to …
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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents
… here. </p> <p>To facilitate pre-clinical biopharmaceutic and pharmacokinetic (B/PK) studies of our lead QA amide analog KZ-41, we developed and validated a novel hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC-MS/MS) analytical assay. An analog of KZ-41 was …