Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Biomolecule detection"”.
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Particle-enhanced biomolecule detection using silicon photonic microring resonators
Protein detection is of great importance in both research and clinical settings. The use of proteins as diagnostic markers of disease is a driving force behind the development of advanced protein detection techniques. Of particular interest is the development of a detection platform which is both …
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Model and analysis of MoS2 nanopore biomolecule detection via membrane current
… ions, charge carriers around the pore rim, and biomolecules. In combination with experimental study and molecular dynamics (MD) calculation, a comprehensive physical analysis of various resistive effects involved in the electronic detection of a single biomolecule in a nanopore of a MoS2 …
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Development of a PDMS Based Micro Total Analysis System for Rapid Biomolecule Detection
… for rapid, multi-purpose, impedance based detection of biomolecules. The major components of the micro total analysis system include a micropump, micromixer, magnetic separator and interdigitated electrodes for impedance detection. Three designs of pneumatically actuated PDMS based …
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Selective molecular transport in nanopore systems
… water filtration, nanofluidics, and biomolecule detection technologies. I give my characterizations of five nanopore systems as my dissertation. First, I present my study of nanopores in polyethylene terephthalate (PET), revealing the mechanism for variance in current rectification …
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Novel enzymatic methods of DNA detection using enhanced Raman scattering
… been a number of significant advances in DNA detection. In particular the advent of the Polymerase Chain Reaction (PCR) has enabled extremely low levels of DNA to be amplified and quantified, and along with fluorescence based detection measurements, has provided a reliable method of detecting …
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Methods for the Detection of Biological Analytes on Dendritic Surface-Enhanced Raman Scattering (SERS) Substrates
… However, traditional SERS struggles with direct detection due to weak signals and inconsistent results, stemming from low analyte concentration at SERS-active sites and irregular formation of “hotspots,” essential for signal enhancement. This doctoral research aims to develop a direct, sensitive …
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Characteristics and Performance of Novel Squarylium Dyes as Fluorescent Probes for the Analysis of Proteins and Viruses by CE-LIF
The importance of biomolecules to many fields has driven the development of more efficient and selective analytical methods for the examination of such compounds. Part of this development includes organic dye molecules to act as noncovalent fluorescent labels to aid biomolecule detection. …
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Microfluidic synthesis, characterization, and applications of bioinspired deformable microparticles
… with nucleic acids and cells, in the context of biomolecule detection and specific cell capture, respectively. Based on the microfluidic particle synthesis technique, stop flow lithography, we fabricate custom particles - including non-spherical 3D capsules and 2D extruded cylindrical rings with …
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Towards a Single Bio-molecule Detector Based on CMOS Nanofluidic Platform
… to build a proteomic platform with a single biomolecule resolution. A prototype chip has been designed and fabricated using standard foundary process incorporating a new implementation of a Solid State Nanopore (SSN) of size 55nm×162nm×100nm (w×l×h) with nanofluidic access channels that …
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Extracellular Vesicle Capture and microRNA Detection
… states, and there has been much focus on earlier detection through the discovery of novel, easily accessible biomarkers via liquid biopsies. Extracellular vesicles have shown promise as a noninvasive biomarker for disease diagnosis and monitoring, and have become a treasure trove of information …
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Advanced flow lithography and barcoded particles
… for high-throughput screening and multiplexed detection of biomolecules. Utilizing advanced flow lithography, we have added advanced functions to the hydrogel particles introducing magnetic beads, tri-layered structures or near-infrared sensing materials. As the first advanced barcoded …
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Magnetic field directed self-assembly of gold Pickering emulsion for preparing patterned film.
… modified MSDS process in enhancing the molecular detection at low concentrations. The UV-vis spectra of the patterns demonstrated the impact of CT and CG on the degree of gold-iron oxide nanoscale interactions leading to tuneability of absorption bands between 390-700nm. The coupling of the …
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Hydrogel-based microfluidic assays for multiplexed medical diagnostics
There is high demand for next-generation biomolecule detection platforms arising from clinical need for more robust point-of-care diagnosis systems, fundamental research need to characterize complex biological processes, and the emergence of personalized medicine. These detection systems should …
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Expanding the toolbox for precision medicine with silicon photonic microring resonators and microfluidic technologies
… single biomarker diagnostics to multiplexed detection methods. The analytical toolbox for studying the molecular basis of human disease has grown tremendously in recent decades and has been motivated in part by the human genome project, with the most dramatic changes seen in sequencing …