Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Biomolecular recognition"”.
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Thermoresponsive Glycopolymers via Controlled Radical Polymerization (RAFT) for Biomolecular Recognition
… applications in many fields, as protein-ligand recognition, on-off switches for modulated drug delivery or artificial organs. Poly(N-isopropylacrylamide) (PNIPAM) is one of the most widely studied polymers due to its lower critical solution temperature (LCST) at ~ 32° C in aqueous solution. …
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DEVELOPMENT OF SURFACE BASED PLATFORMS FOR BIOMOLECULAR RECOGNITION AND PROTEASE ASSAYS
The discovery of analytical tools for biomolecular recognition in the area of diagnostics is a research trend rich in innovative methods. Some of the main drivers found in this area are the constant need for low cost devices and biosensors, simplicity in design and operation, and time efficiency. …
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STUDY OF COLLOIDAL INTERACTIONS MEDIATED BY BIOMOLECULAR RECOGNITION AND BY ELECTROKINETIC FLOWS.
… mediated by two different phenomena - biomolecular recognition and electrokinetic flows. The general purpose of this investigation is twofold: while we investigate new mechanisms providing new forms of colloidal interactions, we also exploit the measured interactions to better describe …
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Effects of Immobilization Matrices and Protein Orientation on Biomolecular Recognition at Solid-Liquid Interfaces
… forces mediating the cytochrome b5-cytochrome c recognition was quantified, and correlated with the measured surface binding behaviors. We found good agreement between force measurements, molecular models, and equilibrium binding behavior.
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Effects of Immobilization Matrices and Protein Orientation on Biomolecular Recognition at Solid-Liquid Interfaces
The specific recognition between biological molecules has been widely exploited in many applications in medicine, biology, and biotechnology. These applications range from biosensors to affinity chromatography. However, the immobilization of biomolecules, such as proteins, often results in the loss …
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Design and characterization of plasmonic nanoprobes and interparticle interactions for surface enhanced raman scattering and biomolecular detection
… nanoparticles upon interacting with the targeted biomolecular species. This thesis work focuses on investigating the interparticle interactions of chemcially-labled and bioconjugated gold and silver based nanoparticles and their influences on the plasmonic coupling for specctroscopic detection of …
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Aptamer-based nano-scale dielectric sensor for protein detection
… sensor was developed capable of monitoring biomolecular recognition events in liquid phase with high sensitivity. The use of this sensor for attaining highly sensitive label-free detection of alpha thrombin using immobilized aptamer probes is demonstrated in this work.
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Engineered biomolecular interactions with inorganic materials : sequence, binding, and assembly
Nanobiotechnology aims to exploit biomolecular recognition and self-assembly capabilities for integrating advanced materials into medicine and electronics. In particular, peptides have exhibited the ability to specifically bind to and/or control the synthesis of diverse inorganic and metallic …
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Assembly and detection of viruses and biological molecules on inorganic surfaces
… exploited. The first project entitled, Biomolecular Recognition of Crystal Defects extended the phage display technique to the detection of crystal defects. The system used is based on the M13 bacteriophage with 7-residue constrained random sequence on protein III. After considerable …
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INVESTIGATION OF BIOMOLECULAR INTERACTIONS FOR DEVELOPMENT OF SENSORS AND DIAGNOSTICS
The highly specific recognition processes between biomolecules mediate various crucial biological processes. Uncovering the molecular basis of these interactions is of great fundamental and applied importance. This research work focuses on understanding the interactions of several biomolecular …
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Organised Chaos: defining different degrees of intrinsic disorder by molecular dynamics methods
… how structural disorder can regulate molecular recognition at the atomistic level of details. Molecular simulation techniques have now come to age and are well suited to play a starring role in structural biology, not only as a support for experimental methods, but also as equal partners and/or …
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Design, synthesis and characterization of new iron and aluminium chelating agents
… and selectivity of both metal-interaction and biomolecular recognition of available ligands (or metal complexes), as well as the targeting for drug delivery; Assessment of the most important physical and chemical properties of metal related compounds, namely metal-chelating efficacy and …