Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Biomolecular interaction"”.
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Advances in molecular-based diagnostics and biomolecular interaction screening using silicon photonic microring resonators
… analysis. Their sensing modality arises from interactions between light and matter—light circumnavigating the microring structure interacts via the accompanying evanescent field with the local environment of the ring, enabling binding events to be readily transduced as a change in the resonant …
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Photochemical harpoons: covalent labels for multi-protein complexes
The identification of the biomolecular interaction partners of small bioactive molecules is a fundamental problem in drug discovery and cell biology. This thesis describes the development of fluorescent chemical probes to identify the biomolecular targets of the known organophosphate toxin, phenyl …
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Biomolecular interactions and cellular effects of steroidal and metallosupramolecular metallodrugs
… Their cytotoxicity, cellular uptake and biomolecular interaction are investigated, showing that the coupling of the steroid confers activity to otherwise inactive complexes, modifying their DNA binding mode and cellular uptake and distribution. Chapter 3 explores the coupling of similar …
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Antibody-based biosensor assays for the detection of zilpaterol and markers for prostate cancer
… optical biosensor capable of monitoring biomolecular interactions in 'real-time'). A zilpaterol-HSA conjugate was used to generate and characterise single chain antibody fragments. A combinatorial single chain (scFv) antibody phage display library was generated to zilpaterol. Splenomic …
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Identification and characterisation of host-pathogen protein-protein interactions in the blood stages of malaria
… affects billions of people. Protein-protein interactions occurring between host and Plasmodium parasites are critical to the pathogenesis of malaria and thus represent prime targets for greatly-needed novel therapeutics. Identifying these host-pathogen interactions is challenging, but recent …
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INVESTIGATION OF BIOMOLECULAR INTERACTIONS FOR DEVELOPMENT OF SENSORS AND DIAGNOSTICS
… Uncovering the molecular basis of these interactions is of great fundamental and applied importance. This research work focuses on understanding the interactions of several biomolecular recognition systems and processes that can provide fundamental information to aid in the rational …