Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Biomolecular Detection"”.
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Suspended microchannel resonators for biomolecular detection
Microfabricated transducers enable the label-free detection of biological molecules in nanoliter sized samples. Integrating microfluidic detection and sample-preparation can greatly leverage experimental efforts in systems biology and pharmaceutical research by increasing analysis throughput while …
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Nanoscale BioFETs for ultrasensitive pH and biomolecular detection
… in many important criteria, such as sensitivity, detection time, sample volumes, need for a label, and selectivity. However, in recent years it has become apparent that the technology has been suffering from lack of reliability, robustness, and repeatability of the devices in fluidic environments. …
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Integrated silicon field-effect sensors and microfluidics for biomolecular detection
… These devices are designed for the label-free detection and recognition of specific biomolecules such as DNA. Label-free methods eliminate the time-consuming and costly step of tagging molecules with radioactive or fluorescent markers prior to detection. The devices presented here are sensitive …
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Low-noise electronic readout for high-throughput, portable biomolecular detection in microchannel arrays
There's not much that can be done to make research easier - but excitement and passion are two key elements of success, and two of the many things I have learned from my advisor, Scott Manalis. It has been (and will continue to be) an awesome opportunity that I am especially thankful for, to work …
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Design and characterization of plasmonic nanoprobes and interparticle interactions for surface enhanced raman scattering and biomolecular detection
… nanoparticles upon interacting with the targeted biomolecular species. This thesis work focuses on investigating the interparticle interactions of chemcially-labled and bioconjugated gold and silver based nanoparticles and their influences on the plasmonic coupling for specctroscopic detection of …
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Instrumentation for a distributed feedback laser biosensor system
… performance of the label-free high-resolution biomolecular detection system is optimized for use in applications that require the study of large quantities of parallel interactions that could be adversely affected by the use of molecular labels, such as high-throughput pharmaceutical drug …
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Microfluidic Tools for Advanced Biomolecular Characterisation
… and interact, it is vital to have tools for biomolecular detection, quantification and fundamental physicochemical characterisation. In this thesis, I have focused on the development of new microfluidic approaches enabling quantitative analysis of biomolecules. First, I describe a …
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Improving multiplexed RNA detection assays by interfacing enzymatic amplification strategies with silicon photonic microring resonators
… the landscape of next-generation multiplexed biomolecular detection platforms while also developing the motivation to use enzymatic processing of nucleic acids to produce ultra-sensitive detection platforms. Chapter 2 gives an exhaustive review of current microRNA (miRNA) detection platforms, …
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Microfabricated Acoustic Sensors for the Detection of Biomolecules
… platform, a specific and high affinity biodetection platform must be optimized, and the microfabricated sensors must be designed to have high sensitivity and maintain good performance in a liquid environment. A biomolecular sensing system that uses high affinity peptide aptamers and a …
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Silica Nanoparticle-based Novel Fluorescent Biosensors with Conjugated Polyelectrolyte-sensitized Signals
The development of sensitive, low-cost and fast biomolecular detection is a key issue for clinical diagnosis of genetic and pathogenic diseases. This thesis presents the research that is focused on the design and fabrication of silica nanoparticle (NP) based fluorescent biosensors with the aid of …
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Dual parametric sensors for highly sensitive nucleic acid detection
… for the highly sensitive and label-free detection of Nucleic Acid hybridization. These novel capacitive sensors with nano-scale electrode spacing offer solutions to many problems suffered by the conventional signal transduction mechanisms, thereby immensely improving the sensitivity of …
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On-chip parallel detection of foodborne pathogens using loop-mediated isothermal amplification
Inexpensive, sensitive and specific detection of infectious agents is a critical milestone for preventing disease spread in both the developed and underdeveloped worlds. Rapid and accurate detection of pathogens is especially important for control and treatment of foodborne diseases. According to …