Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 489 for “"Biomolecular"”.
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Microfluidics for Biomolecular Studies
Large-scale integrated microfluidic networks were designed and fabricated in order to carry out large combinatorial synthesis and screening. The microfluidic devices contained a series of small chambers with a total volume of one nanoliter to contain each of the combinations in the screening …
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Biomolecular Modeling at Scale
… This work introduces deep learning methods for biomolecular modeling at scale, designed for efficiency, adaptability, and accessibility. The early chapters present models developed in the general molecular domain, including prediction of structure and interactions for proteins, nucleic acids, …
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Input-output biomolecular systems
… and respond to their environment is encoded in biomolecular reaction networks, in which information travels through processes such as production, modification, and removal of biomolecules. These reaction networks can be modeled as input-output systems, where the input, state and output variables …
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Multiscale Modeling of Biomolecular Complexes
Macromolecular complexes carry out cellular processes that span many different length and time scales. Central to their function are both large-scale conformational changes, and atomic-atomic scale events. Molecular dynamics (MD) simulations are well suited to study the structural dynamics of such …
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Microfluidic Methods for Biomolecular Analysis
Microfluidics is the science and technology of manipulating fluids at small scales ranging from microlitres (10$^{-6}$) to picolitres (10$^{-12}$). The fundamental physics is distinct from fluid behaviour on bulk scales and laminar flow is the key characteristic on this scale. Microfluidic systems …
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Biomolecular Condensates in Transcriptional Regulation
… mysterious for decades. However, recent study of biomolecular condensates has reframed our understanding of these cooperative interactions. Condensates are membrane-less compartments that concentrate components involved in the same biochemical processes. This thesis examines the formation and …
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SEMICLASSICAL VIBRATIONAL SPECTROSCOPY OF BIOMOLECULAR SYSTEMS
In questa tesi, presento un lavoro teorico sulla dinamica semiclassica che ha permesso di riprodurre con precisione gli spettri vibrazionali di molecole di interesse biologico. All’inizio del mio dottorato, ho sviluppato un software per eseguire la dinamica di Adiabatic Switching utilizzando …
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Biomolecular engineered sensors for diagnostic applications
Electrochemistry is a powerful technique that offers multiple possibilities and which is in constant evolution. Simple modifications of the electrode surface can result in an improvement of the selectivity and sensitivity of the method. However some situations require more complex modifications …
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Biomolecular Simulation on Thousands of Processors
Submitted by Meng Tao (mengtao2@illinois.edu) on 2012-10-26T22:39:28Z No. of bitstreams: 1 phillips_James.pdf: 7662495 bytes, checksum: ba41201fd0ec6a43b13f889bf094fcc2 (MD5)
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Multiscale Modelling of Biomolecular Phase Behaviour
… realism and explanatory power of coarse-grained biomolecular simulations.
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Biomolecular Simulations with Machine Learning Potentials
… crystals, is tested on out-of- distribution biomolecular systems, demonstrating qualitatively accurate predictions. We further demonstrate that these predictions can be improved by finetuning the foundation model on the system of interest.
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Quantum Mechanically Derived Biomolecular Force Fields
… range of biological phenomena. However, current biomolecular force fields assume that parameters must be fit to the properties of small molecules and subsequently transferred to model large proteins. Here, we look to challenge this assumption and create a new class of QUantum mechanical BEspoke …
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Microfluidic Tools for Advanced Biomolecular Characterisation
… and interact, it is vital to have tools for biomolecular detection, quantification and fundamental physicochemical characterisation. In this thesis, I have focused on the development of new microfluidic approaches enabling quantitative analysis of biomolecules. First, I describe a …
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Modeling Biomolecular Interactions with Generative Models
… challenge in biology. However, understanding biomolecular interactions, a critical problem for advancing drug discovery and biological research, remained unsolved. This thesis presents our research to redefine the machine learning approach to this problem, modeling structures with a new …
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Learning the language of biomolecular interactions
Proteins are the primary functional unit of the cell, and their interactions drive cellular function. Interactions between proteins are responsible for a wide variety of functions raning from catalytic activity to cellular transport and signaling, and interactions between small molecules and …
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Suspended microchannel resonators for biomolecular detection
Microfabricated transducers enable the label-free detection of biological molecules in nanoliter sized samples. Integrating microfluidic detection and sample-preparation can greatly leverage experimental efforts in systems biology and pharmaceutical research by increasing analysis throughput while …
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Solid-State NMR: investigations of biomolecular structure
Solid-state nuclear magnetic resonance methods were used to characterize the structure of biological molecules in lyophilized and hydrated environments with and without the presence of other molecules such as drugs, lipids, and surfaces. Revealing the structure of biomolecules by mimicking its …
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Impedance spectroscopy for cellular and biomolecular analysis
The application of microfabrication technology to molecular and cell biology has motivated the rapid development of a novel class of microdevices collectively known as ‘Lab On a Chip’ devices.<br/>Impedance spectroscopy is a non-invasive, label-free, analytical technique that is amenable to …
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Technological advancements towards paper-based biomolecular diagnostics
… abilities and a large collection of biomolecular sensors. However, these technologies fundamentally require transcription and translation, limiting their applicability to cellular contexts In vitro cell-free expression systems that contain transcription and translation machinery …
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Single molecule fluorescence studies of biomolecular interactions
Single molecule fluorescent techniques have become standard approaches to study protein-DNA interactions. However, these techniques have largely been confined by limitations in assays to studying the interaction between simple DNA substrates and a single protein. During my PhD I developed several …
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