Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Biomechanics and Biotransport"”.
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Characterization of Arterial Flow for Junctional Bleeding Control
… compression with constant cross-sectional area and varying cross-sectional area reduction with constant length in order to better understand how to control junctional hemorrhaging. The hypotheses of this study were that length reduction will have little effect on volumetric flowrate and that …
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Modeling the Long Term Effects of Alendronate on Bone Mass Preservation of the Femur with Articular Surface and Total Hip Replacements
… hip arthroplasty is of interest to researchers and clinicians for predicting the longevity of the prosthetic implant and the surrounding bone. Recently clinicians have been administering bisphosphonate drugs in an attempt to reduce the bone resorption due to stress shielding caused by these …
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Theory for diffusional encounters in heterogeneous environments and multivalent electrolyte screening of charged interface
… environments, such as porous catalysts and biological environments. We discovered a dimensionless number that is the dominant scaling variable and obtained, for the first time, an analytical expression for the encounter rate. The new theory generalizes the classic Smoluchowski diffusion …
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A three constituent mixture theory model of cutaneous and subcutaneous tissue in the context of neonatal pressure ulcer etiology and prevention
… ischemia, impaired interstitial fluid flow, and sustained mechanical loading of cells have all been hypothesized as mechanisms of pressure ulcer (PrU) etiology. Time-varying loading has experimentally been shown to increase fluid flow in human skin <em>in vivo.</em> Towards the design of …
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Understanding preferred leg stiffness and layered control strategies for locomotion
… achieve the kind of locomotion stability animals and humans have. In order to develop legged robots with greater stability, we need to better understand general locomotion dynamics and control principles. Here we demonstrate that a mathematical modeling approach could greatly enable the discovery …
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Unveiling the mechanical behavior of the rod-like microstructure in the radular teeth of cryptochiton stelleri
… blocks, like hydroxyapatite or aragonite, and the compliance of the organic surroundings. Unique mechanical properties (e.g. light density and toughness) distinguish bio-composites from common engineering materials. A key example is the highly mineralized shell of the radular teeth of the …
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Dislocation Mechanics of Total Hip Arthroplasty: A Combined Experimental and Computational Analysis
… therefore researchers rely on experimental and computational methods. A custom MATLAB script and an experimental procedure utilizing a six-degree of freedom actuator were developed to further understand how various surgical considerations affect dislocation mechanics in total hip …
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Specimen-Specific Natural, Pathological, and Implanted Knee Mechanics Using Finite Element Modeling
<p>There is an increasing incidence of knee pain and injury among the population, and increasing demand for higher knee function in total knee replacement designs. As a result, clinicians and implant manufacturers are interested in improving patient outcomes, and evaluation of knee mechanics is …
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Inverse Dynamic Analysis of ACL Reconstructed Knee Joint Biomechanics During Gait and Cycling Using OpenSim
… ligament) injuries of the knee joint alter biomechanics and may cause abnormal loading conditions that place patients at a higher risk of developing osteoarthritis (OA). There are multiple types of ACL reconstruction (ACLR), but all types aim to restore anterior tibial translation and …
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Mechanical Properties of Bone Due to SOST Expression: A 3-Point Bending Assessment of Murine Femurs
… bone formation both during skeletal maturation and full maturity. This study attempts to determine significant differences in the mechanical properties of bone that expresses SOST compared to bone that does not. One hundred femur samples from 6, 8, and 12 month old mice were obtained from …
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A 2-D Analysis of Strains at the Interface Between the Brain and the Skull
… that are mediated both by the shape of the skull and by the connective tissue that anchors the brain inside the skull. Strain magnitudes were elevated in the sub-arachnoid space, and strain concentrations were evident near the<em> falx cerebri</em>. Additionally, we found that strain magnitudes at …
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Assessment of material properties in bone surrounding microdamage
… bone that occurs from normal mechanical wear-and-tear or fatigue, leading to impaired tissue material properties and in some instances atypical femoral fractures.</p> <p> In these studies, we assessed the effects of acute fatigue, fatigue induced remodeling, and fatigue microdamage with …
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Intranuclear strain measured by iterative warping in cells under mechanical and osmotic stress
<p>The nucleus is a membrane bound organelle and regulation center for gene expression in the cell. Mechanical forces transfer to the nucleus directly and indirectly through specific cellular cytoskeletal structures and pathways. There is increasing evidence that the transferred forces to the …
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Restoration of Bone Material and Microstructural Properties after Long-Term Remodeling Suppression
… microdamage, altered matrix mineralization and reduction in normal bone tissue heterogeneity, causing impaired strength and fracture toughness. The most severe consequence to patients, while rare, is Atypical Femur Fractures (i.e., complete fatigue fractures of the femoral shaft). To …
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Diffuse Damage Repair Mechanism in Bone
… is a result of fatigue, creep or ‘wear and tear’ caused by physiological activities and largely contributes to bone fragility. Bone, unlike engineered materials, has the ability to repair the microscopic cracking or microdamage through targeted, osteoclast-mediated bone remodeling. This …
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Youth Pitching Kinematics: Associations with Body Overweight Parameters
… between injury-related kinematic parameters and overweight measures for youth baseball pitchers. The injury-related kinematic parameters considered were measurements 1) at foot contact: stride length, front foot position, shoulder external rotation, shoulder abduction, and elbow flexion; 2) …
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Multi-scale Assessment of Bone Mechanics and the Mineral Phase of Intramuscular Bone of Atlantic Herring Fish
… of a soft organic phase consisting of collagen I and non-collagenous proteins, and a hard inorganic phase consisting of mineral nanoplatelets. Given it’s compositional properties, bone is a unique stiff, tough, and strong biomaterial, making it exceptionally difficult to synthesize <em>ex …
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Effect of Rolling on Viscoelastic Fluids Using a Novel Testing Device
… different lubricants (motor oil, synovial fluid and Hyaluronic Acid (HA)) to varying loads (1kg, 2,kg, 3kg and 4kg) and speeds (10, 25, 48 and 91 mm/s) applied on the sample fluids for 10 cycles. We were able to examine the effect of different speeds within each load for each of the fluid that …
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Mechanical Simulation of Articular Cartilage Based on Experimental Results
… cartilage (AC) biomechanical properties before and after growth. Previous research has noted limitations in the CGFEM such as model convergence with growth periods greater than 12 days. The main aims of this work were to address these limitations through (1) implementation of an exact material …
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