Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Biomaterials. Drug Delivery"”.
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Bioorthogonal Functionalization of Elastin-like Polypeptides
… engineering unlocks the potential to tailor drug specificity and pharmacokinetics, rationally design biomaterials, understand and define protein structure, and probe cellular function with molecular precision. These technological feats are made possible with a few simple biological …
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Nanotherapies for Treating Prostate Cancer
… polymeric nanocarriers to facilitate anticancer drug and nucleic acid delivery.</p> <p>It was hypothesized that simultaneously targeting androgen-androgen receptor (AR) and X-linked inhibitor of apoptosis protein (XIAP) signaling pathways would be effective in treating prostate cancer. The effect …
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A foe-inspired friend: Constructing a tumor tissue-mimicking biomaterial to study intratumoral drug transport
… tumor microenvironment and its implementation on drug screening of new anticancer therapies is an active challenge that sits at the interface of biomaterials and cancer biology. As recent clinical successes of human intratumoral therapies stimulate research on intratumoral delivery, a need for an …
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Development of Multifunctional Drug Delivery Systems for Locoregional Therapy
Locoregional treatment is the specific delivery of therapeutics to their desired sites of action with minimized systemic adverse effects. In this approach, drug is administered through topical instillation, inhalation, intra-lesional or intra-arterial injection. Decades of experience in …
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Granular Hydrogels for Localized Nanoparticle Delivery
… and socioeconomic burden, yet effective topical delivery of advanced therapeutics remains a major challenge. Nucleic acid–based therapies hold enormous promise for locally modulating gene expression and restoring skin homeostasis, but their translation is limited, among others, by the lack of …
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Sustained Release of Growth Factors from Hyaluronic Acid Hydrogels and Polyethylene-Glycol Microparticles for Axonal Growth
… studies, but there is a lack of effective delivery methods capable of maintaining their biological activity. In this work, we explored the feasibility of using injectable hyaluronic acid (HA) hydrogels and polyethylene glycol-diacrylate (PEG-DA) microparticles as platforms for sustained …