Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Biomaterial Platforms"”.
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Development of single-cell Raman spectroscopy for noninvasively screening the differentiation of living stem and progenitor cells in biomaterial platforms for 2D and 3D cell culture
… cells for the treatment of malignant diseases, biomaterials have been studied for the optimization of delivery and potency of stem cell therapies. The idea is to incorporate a biomaterial that is bio-compatible and bio-degradable to facilitate the delivery of stem cells into damaged tissues with …
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Development of collagen scaffolds to address biomechanical design criteria for tendon–to–bone repair
… poor functional outcomes (re-failure >90%). Biomaterial platforms and tissue engineering methods offer an alternative approach to address these injuries. Although current methods are moving towards multi-tissue regenerative approaches to address these injuries, it remains a challenge to fully …
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NOVEL SHAPE MEMORY AND MULTI-SHAPE MEMORY POLYMERS FOR BIOMATERIAL APPLICATIONS
<p>Biomaterial platforms have been used to probe how cells respond to chemical, topographical or mechanical changes in their environments. However, these traditionally static biomaterial platforms have not enabled the study of how cells respond to dynamic changes in their environment. Driven by a …
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Developing a biomaterial model of the glioblastoma perivascular niche to investigate the effects of angiocrine signals on disease progression
… of new therapeutics. Currently, in vitro platforms that recapitulate the architecture and cellular interactions found in the in-vivo PVN are lacking and limit the exploration and discovery of angiocrine cues. Thus, this dissertation focuses on the development of biomaterial platforms to …
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A noninvasive screening tool for cell fate determination using raman spectroscopy and machine learning in tissue engineering and microbiology applications
… have had limited success. Therefore, miniature biomaterial platforms for screening thousands of putative stimuli have been devised to identify the combinations of factors that drive self-renewal in vitro while reducing the numbers of rare HSCs required for screening. To correlate the extrinsic …
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Single-cell analysis of hematopoietic cell fate on niche-mimetic platforms using Raman microspectroscopy
… have met with limited success. Miniaturized biomaterial platforms that present tens to hundreds of putative niche components can help screen individual factors or their combinations which drive quiescence, self-renewal and differentiation in vitro while reducing the numbers of rare cell …
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Bioorthogonal Functionalization of Elastin-like Polypeptides
… and pharmacokinetics, rationally design biomaterials, understand and define protein structure, and probe cellular function with molecular precision. These technological feats are made possible with a few simple biological ingredients: nucleotides, sugars, and amino acids. These …