Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 315 for “"Biomaterial"”.
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Biomaterial tools for modeling endometriosis
Endometriosis is a common gynecological disorder that can cause chronic pain and infertility. To better understand mechanisms of disease etiology and progression, researchers are increasingly turning to model systems. In vivo approaches have notable limitations, including limited ability to model …
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Electrospun Nanocellulose: A New Biomaterial
Science and engineering studies on biocompatible implantable materials for tissue and organ repair have recently focused on polymeric materials to serve as scaffolds for cellular integration. Cellulose in many forms has been demonstrated as potential biopolymer for tissue engineering; however, it …
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Bone biomaterial engineering. Modification of cell and tissue response by mechanical stimulation and biomaterial nanostructure
Contains fulltext : 118073.pdf (Publisher’s version ) (Open Access)
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Development of an endometrial inspired biomaterial
… medicine applications, a common limitation to biomaterial cultures and implants is nutrient transport. Unlike native tissue which contains a dense vascular network to provide nutrients and eliminate waste, biomaterials rely solely on diffusive transport which is often insufficient at …
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Engineering biomaterial surfaces with N-cadherin
N-cadherin is a key protein that is responsible for cellular adhesion to neighboring cells in mesenchymal tissues. It plays a significant role in neural development, regeneration, and pathological processes. Recently, efforts were increasingly made to better understand biological function of …
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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Mechanistic Investigation of A Hemostatic Keratin Biomaterial
… by uncontrolled bleeding. Human hair keratin biomaterials have demonstrated efficacy in controlling hemorrhage in both small and large animal models; however little is known about the mechanism by which these proteins aid in blood clotting. Inspection of the amino acid sequence of known …
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Order and Disorder in Protein Biomaterial Design
… untapped principle for the design of functional biomaterials.</p>
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Development of Dual Extruder Biomaterial 3D Printer
… extruder capable of depositing viscous biomaterial hydrogels. The integration of a first-of-its-kind dual-extruder system enables the fabrication of multi-material prints and the exploration of biomaterial composites and complex geometric structures, thereby advancing sustainable, …
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New polymeric biomaterial interfaces for biosensor applications
… sensors, we have examined two PEO-based biomaterials that can be patterned to generate cellular array templates: poly(allylamine)-g- poly(ethylene glycol) graft-copolymer and poly(ethylene glycol) dimethacrylate hydrogel. Poly(allylamine)-g-poly(ethylene glycol) polycation …
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Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds
… or long-term disability is a frequent prognosis. Biomaterial scaffolds are promising for use in neural reconstruction, but to date, no neuroinductive biomaterials capable of acting directly on regenerative cells to stimulate nerve growth have been identified. The goal of this dissertation work was …
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Developing a medium-throughput collagen biomaterial model system
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Spatial control of ligand presentation on biomaterial surfaces
… the spatial distribution of adhesion ligands on biomaterial surfaces. Substrates were prepared on which cell-surface interactions are controlled by modifying non-adhesive poly(ethylene oxide) (PEO) hydrogels with the minimal cell-adhesion peptide sequence GRGDY (RGD). The peptide is tethered to …
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Engineering polymer biomaterial interfaces for promoting cellular morphogenesis
Three-dimensional in vitro tissue and organ cultures have immense promise as models of human pathophysiology and stand to make a significant impact on the process of drug discovery and development. Many existing model systems do not capture the relevant complexity of the native tissue environment, …
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Modulating the Inflammatory Response of Macrophages on Biomaterial Surfaces
… materials and poses significant challenges for biomaterials-based medical applications, often leading to the degradation or fibrous encapsulation of an implanted device. The host response is largely dictated by the proteins that adsorb to the biomaterial surface, including damage-associated …
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Design of Engineered Biomaterial Architectures Through Natural Silk Proteins
… within the rapidly expanding field of smart biomaterials. Study of the process of building macroscopic silk fibers provides insight into the initial steps in the broader picture of silk assembly, yielding biomaterials with greatly improved attributes in the assembled state over those of …
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Development and study of synthetic polypeptides for biomaterial applications
Creating new scaffolds for cells is critical to the development of new tissue engineering techniques. In this work, the synthesis of new polypeptide systems is discussed. These systems are intended for the formation of hydrogels which can then be used as cell substrates. Attempts at using the …
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A Biomaterial-based Stem Cell Therapy for Retinal Regeneration
… was observed when the cells were injected in our biomaterial compared to injection in saline. In a third vivo experiment, a novel human cone progenitor (hCP) cell line was created and studied in retinal degenerative animal models (such as RCS rats and RD1 mice). hCPs were found to engraft in high …
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FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING
… and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an …
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