Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Biomarker detection"”.
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Statistical Considerations in Designing for Biomarker Detection
… to develop a statistical method for use in rapid detection of biological agents using portable gas chromatography mass spectrometry (GC/MS) devices. Of particular interest is 2,6-pyridinedicarboxylic acid (dipicolinic acid, or DPA), a molecule that is present at high concentrations in spores of …
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Miniaturized electromagnetic biosensors for circulating cancer biomarker detection
… low cost, and highly accurate tools for cancer detection and treatment. Recently, liquid biopsy and circulating cancer biomarkers such as circulating tumor cells (CTC), extracellular vesicles (EV), and cell free DNA (cfDNA) have gained great attentions for early diagnosis, prognosis, and …
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Statistical Learning for Gene Expression Biomarker Detection in Neurodegenerative Diseases
… learning approaches are used to detect biomarkers for neurodegenerative diseases (NDs). NDs are becoming increasingly prevalent as populations age, making understanding of disease and identification of biomarkers progressively important for facilitating early diagnosis and the screening …
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Development of biosensors for biomarker detection and clinical therapeutic drug monitoring
… technology. The overlapping of dementia biomarkers and heterogeneity in symptoms has limited the differential diagnosis of AD using the current diagnostic techniques. Antimicrobial resistance along with severe septicaemia are the emerging global health threats in absence of personalised …
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Cavity coupled photonic crystal enhanced fluorescence for high sensitivity biomarker detection
With the rise in fluorescence-based testing of biomarkers in samples, the use of dielectric optical resonators has increased dramatically. These photonic crystals make fluorophores emit more light through a process called enhanced fluorescence which in turn allows for more signal to be collected …
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Low-Cost Electronic Microfluidics for Multiplexed Point-of-Care Biomarker Detection
… in healthcare, as they can aid in disease detection, monitoring, and treatment, and even inform public policy. However, while qualitative (yes/no) PoC sensors are abundant (i.e. pregnancy tests, rapid COVID19 tests), low-cost, automated, quantitative PoC platforms are limited. Yet, given …
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Applications of Engineered Proteins in Redox Biology and Biomarker Detection Assay Development
… encoded biosensors/probes or affinity agents for biomarker detection. This thesis explored a few topics using assays developed with engineered proteins. The genetically encoded hydrogen peroxide generator, D-amino acid oxidase (DAAO), was used to understand the hours-long intracellular hydrogen …
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Development of chemical tools for biomarker detection and targeted therapeutics for precision medicine
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Fabricating protein arrays using Dip-pen Nanolithography techniques for improved sensitivity of biomarker detection
… DPN was used to develop a platform for the detection of the biomarker, prostate-specific antigen (PSA), using optical microscopy techniques. Investigations into creating a faster patterning method, with reduced feature sizes of antibodies are first detailed. The aim was to develop a …
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Sensitive microarray-based biomarker detection using photonic crystal enhanced fluorescence and label-free imaging
Fluorescence-based biomarker detection in serum, saliva, urine, or breath condensate samples holds great promise for disease diagnostics and therapy monitoring because of its non-invasive nature. The microarray format, for its high-throughput and low analyte consumption characteristics, is …
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Delivery of molecular-specific optical contrast agents for cancer biomarker detection in live cells and tissues
… promise as potential non-invasive probes for the detection of cancer and its precursors. The topical use of optical contrast agents in vivo has been hindered, however, by the difficulty of delivering macromolecules through mucosal tissue. My goal was to develop a robust strategy for the delivery …
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Development of a concentration-enhanced mobility shift assay platform for aptamer-based biomarker detection and kinase profiling
New methods to quantify rare biomarkers from patient samples are critical for developing point-of- care diagnostic platforms. To be compatible with resource limited settings, these assays have to provide fast and accurate results without sacrificing ease of use. Biosensing in homogeneous fashion is …
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A Mass Spectrometry-Based Method For Quantification Of Human Metallothionein Isoforms And Usefulness In Biomarker Detection Of Cancers And Metal Toxicity
… the usefulness of human MT isoforms as potential biomarkers for specific diseases or environmental exposures to heavy metals.</p>
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A novel genomic approach to multiple cancer diagnostics using mutations in blood bound EV RNA: Machine Learning Methods For Biomarker Detection and Protein Mutation Assessment
Identification of biomarkers is critical for early detection of cancers such as pancreatic ductal adenocarcinoma (PDAC), which is often diagnosed in later stages. Extracellular vesicles (EVs) released into the blood from tumour cells make good biomarkers for this purpose by protecting their …
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Ultra-high Field MRI Methods for Precise Anatomical and Spectroscopic Measurements in the Brain and Application to Neurological and Neuropsychiatric Diseases
… bases of these diseases and identify potential biomarkers to improve diagnosis, monitoring, and treatment efficacy across multiple diseases.</p> <p>Magnetic resonance imaging (MRI) is a noninvasive imaging technique which facilitates detection of brain lesions and visualization of the brain …
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Next generation instrumentation for photonic crystal biosensors: a passage to early detection of cancer
… point-of-care diagnostic tool for early detection of cancer. We identified a biomarker detection approach done using photonic crystal enhanced fluorescence (PCEF) instrumentation as the best way to achieve this goal. We introduce a model for predicting enhanced fluorescence (EF) …
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Design and Development of Emerging Platforms for Personal Healthcare
… speech recognition, oral health monitoring, and biomarker detection. A wearable graphene-based strain gauge was developed to classify silent speech using machine learning algorithms. Two sensor designs were evaluated: an initial Lycra-based sensor, which demonstrated the feasibility of the …
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Preliminary investigation on optical cavity-based biosensor using double-sided tape.
Early detection is the key to improving survival rates of diseases like cancer. Biosensors and microfluidics can aid in making detection more affordable and accessible. Our team has developed a foundational optical cavity-based biosensor capable of biomarker detection using low-cost fabrication …
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Development of Electrochemical Immunosensor for Oral Cancer: Initial Outcome
… immunosensor targeting the S100A7 protein, a biomarker associated with OSCC risk. The biosensor's sensitivity and specificity were assessed across a range of clinically relevant concentrations in artificial serum and artificial saliva, simulating different stages of the disease. Additionally, …
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Biomolecular function and failure across length scales
… biological questions and enable disease biomarker detection. These advancements enable the discovery of previously unexplored emergent protein functions arising from condensation, such as the formation of electrochemical gradients and antimicrobial activity. Furthermore, this thesis …
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