Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 57 for “"Biology, Virology"”.
-
Temporal gene expression and regulation in T4 phage
… They are also essential tools in molecular biology, shedding light on fundamental biological concepts. T4 phage, with its complex lifecycle and genetic content, has been instrumental in many such discoveries. However, many questions regarding gene regulation in T4 phage remain unanswered. In …
-
Neurological Consequences of Viral Encephalitis: Behavioral Deficits, Neuronal Restructuring, and Therapeutic Interventions
… functions. Together, these insights bridge cell biology, virology, and neuropathology and offers innovative strategies to understand and combat alphavirus-induced neuronal damage. It provides a valuable framework for developing antiviral therapies and neuroprotective interventions, with broader …
-
Phenotypic Characterization of Mutations Made to the Envelope Protein of West Nile Virus
West Nile virus (WNV) is a mosquito-borne flavivirus that can cause severe neuroinvasive disease resulting in death or long term neurological sequela. The envelope (E) protein of flaviviruses has three domains and is the major component of the virion surface, with the EIII being the putative …
-
NEW INSIGHTS INTO THE MOLECULAR PATHOGENESIS OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS
Severe Fever with Thrombocytopenia Syndrome (SFTS) virus (also known as Dabie Bandavirus) is an emergent tick-borne Phlebovirus isolated from patients presenting with hemorrhagic manifestations. Case fatality rates range from 12-50%, and over 1 billion people live in regions where the virus is …
-
Description of interactions of Ebola virus with a putative reservoir species using next-generation sequencing
… an extremely powerful and flexible tool in virology over the past decade as new library preparation techniques have been developed that permit the selective sequencing of small RNAs, and the characterization of entire viral populations at incredible levels of detail. For this work, I …
-
HTLV-1 bZIP FACTOR ACTIVATES MYOFERLIN EXPRESSION TO FACILITATE HTLV-1 INFECTION AND MIGRATION OF INFECTED T-CELLS
Human T-cell Leukemia Virus type 1 (HTLV-1) is a complex retrovirus responsible for diseases such as Adult T-cell Leukemia (ATL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The viral protein HBZ is consistently expressed in infected individuals and plays a crucial role …
-
Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein
Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 interacts with procaspase-8 as a means to inhibit NF-kappaB activation, while the …
-
An Interactive Natural Host Model System for a Swine Alphaherpesvirus: Aujeszky's Disease Virus Cell Interactions in Immortalized Porcine Olfactory Neuroblasts
Following the comprehensive characterization of the novel cell line, we infected the OBGF400 cells with ADY and investigated the ensuing comprehensive gene expression profile in comparison to a non-neuronal cell line, again by utilizing the Affymetrix array chip. The conducted studies exerted a …
-
Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
This dissertation elaborates on M2's molecular functioning as a viral immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular …
-
Novel Lineage Specific Genes Expressed in Cattle Placenta: Discovery, Functional Annotation and Evolution
To answer our original question as to the origin of these genes and whether they represent genes that have undergone lineage-specific changes, comparative genomics tools were used to generate phylogenetic profiles to determine the presence/absence of novel lineage-specific genes (LSGs) in various …
-
Engineering Viruses for Gene Therapy: Isolating and Characterizing Murine Leukemia Virus With Improved Stability
Inefficient gene delivery continues to be a primary hurdle facing gene therapy. Viruses offer the highest gene transfer capabilities but are not optimized as therapeutics. Applying directed evolution, we randomly mutated the entire genome of amphotropic murine leukemia virus (MLV) and selected for …
-
Coarse-Grained Molecular Dynamics Simulations of Macromolecular Complexes
"Molecular dynamics simulations provide critical insights into molecular mechanisms underlying cellular processes. Most such processes, however, remain out of reach, due to large system sizes and long time scales involved. This thesis describes molecular dynamics simulations of large macromolecular …
-
Proviral Roles of Ebola virus VP35 Ubiquitination
Ebola virus’ structural protein VP35 is polyfunctional and plays vital roles in Ebola’s life cycle from antagonizing the host’s type I interferon pathway to acting as the polymerase co-factor. The mechanisms that regulate which function any given VP35 molecule engages remains unknown. Previously, …
-
HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people worldwide. Genotypes (gt) 1 and 3 are the most prevalent, with gt3 HCV being …
-
The Impact of Powassan Virus and Borrelia burgdorferi Coinfection in Ixodes scapularis Ticks
Ticks (Order: Ixodida) are hematophagous arthropods that transmit a number of medically significant pathogens. Two of these include Powassan virus (POWV) and the spirochete Borrelia burgdorferi, both of which are transmitted by Ixodes scapularis in the northern parts of the United States. Powassan …
-
Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
Yellow fever virus (YFV), a mosquito-borne flavivirus, is responsible for the disease yellow fever (YF), which is characterized by hemorrhagic fever and multiorgan failure. The disease is prevented by a live attenuated vaccine (LAV), strain 17D, that was derived from serial passage of the wild type …
-
HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people worldwide. Genotypes (gt) 1 and 3 are the most prevalent, with gt3 HCV being …
-
Elucidating Mechanisms of Immunity to Nipah Virus Infection through Generation of Attenuated Viruses and a Single-Cycle Vectored Vaccine
Nipah virus (NiV) is an emerging paramyxovirus that has caused outbreaks with high case-fatality rates in South and Southeast Asia. Mechanisms of NiV virulence are poorly understood, and there is no licensed vaccine nor treatment. Accessory proteins produced from the NiV P gene through …
-
Investigating the Effects of Glycochenodeoxycholic Acid on Mutant Murine Norovirus P-Domain Structure and Antibody Interactions
Viral gastroenteritis is most frequently caused by exposure to norovirus (NoV) through fecal–oral transfer resulting in severe vomiting and diarrhea lasting between 24 to 48 hours, yet for certain individuals, these infections can be fatal. With epidemic strains continuously emerging, it is …
-
Innate immunity in Zika Virus infection and neurogenesis deficits
Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised public health concerns globally. Clinical and animal studies have shown that miscarriage and brain malformation are more frequent when infection occurs during early pregnancy. ZIKV-associated microcephaly is most likely …
Page 1 of 3