Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 286 for “"Biology, Neuroscience."”.
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Technology development in mouse genetics and epigenetics
… in many areas of research such as developmental biology, cancer biology, neuroscience and genetics. However, even though the methods to make transgenic mice and gene knockin and knockouts have been successful, they are very inefficient, labor intensive and costly. Therefore, in this thesis we …
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Single-View 3D Reconstruction of Animals
… immersive games, as well as applications in biology, neuroscience, ecology, and farming. However, this is a challenging problem because these objects can appear in many different forms. This thesis begins by providing the first fully automatic solution for recovering a 3D mesh of a human body …
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Novel tool for sampling in vivo neurochemicals from the central nervous system.
Novel tool for sampling in vivo neurochemicals from the central nervous system.
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Molecular, cellular and physiological aspects of complexes between Gs alpha and tubulin.
Molecular, cellular and physiological aspects of complexes between Gs alpha and tubulin.
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The role of thromboxane A(2) receptor signaling in oligodendrocyte development.
The role of thromboxane A(2) receptor signaling in oligodendrocyte development.
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Effect of charge alterations on C- and N-terminal domains of the inward rectifying potassium channel.
Effect of charge alterations on C- and N-terminal domains of the inward rectifying potassium channel.
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Interaction of components I and II with transducin beta gamma subunits and regulation by phosphorylation.
Interaction of components I and II with transducin beta gamma subunits and regulation by phosphorylation.
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Stress-activated protein kinase 1 and fast axonal transport in Huntington's disease.
Stress-activated protein kinase 1 and fast axonal transport in Huntington's disease.
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Investigating the Cell-specific Mechanisms That Drive Sex Differences During Neuropathic Pain Development
… Despite advances in the field of pain neurobiology, there remains a clear disconnect between the cellular mechanisms that underlie maladaptive chronic pain in males and females. Moreover, a lack of studies directed towards interventions during early neuropathic pain development make it …
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Integration of Homeostatic and Hedonic Brain Centers in the Regulation of Feeding Behaviors
Binge-eating disorder (BED) and obesity are major public health problems that are associated with psychosocial distress, impairments in daily function, and life-threatening co-morbidities. Both diseases are driven by maladaptive feeding behaviors, namely pathological overconsumption of high-fat …
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p53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's Disease
The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis. Disruption of p53 results in a wide range of disorders including cancer, metabolic diseases, and neurodegenerative …
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A Two-Pronged Approach to Stemming the Opioid Epidemic: Preclinical Strategies for Substance Use Disorder Medications Development and Liquid Biopsy Detection of Inflammatory Pain
The U.S. is in the grips of a public health crisis driven by misuse of psychoactive drugs (e.g., prescription opioids, heroin). In consequence, this has generated a multitude of health issues, including overdoses, deaths and disability, as well as the increased incidence of opioid use disorder …
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Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
A group of neurodegenerative diseases that are pathologically characterized by the presence of intracellular abnormal aggregation of α-Synuclein (α-Syn) in Lewy bodies (LBs) and Lewy neurites (LNs), are collectively known as synucleinopathies. Even so, tau protein pathology is abundantly found in …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… and efforts to unmask its complex neurobiology constitutes ongoing areas of research. Indeed, impulsivity has been characterized as a phenomenon driven by the dopamine (DA) and serotonin (5-HT) systems, however the glutamate (Glu) system, localized throughout the central nervous system …
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Investigating Mechanisms of Nucleoside Reverse Transcriptase Inhibitor Induced Sensory Neuropathy
The success of antiretroviral therapy (ART) has generally improved the survival of HIV-infected patients. However, patients on ART whose HIV disease is well controlled show peripheral sensory neuropathy (PSN), supporting the idea that the ART may cause PSN. Although the nucleoside reverse …
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Tissue injury and remodeling in rat hippocampal dentate gyrus following sodium-potassium-ATPase inhibition.
Na+, K+-ATPase is a ubiquitous membrane enzyme that plays an important role in maintaining neuronal excitability, ionic homeostasis and cell survival. Although failure of the Na+, K+-ATPase pump has been implicated in the pathophysiology of a variety of neurological conditions, the timeline and …
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Angiotensin II modulates glutamate-induced depolarizations and synaptic transmission in rat locus coeruleus neurons in vitro.
Considerable evidence now supports a neurotransmitter or neuromodulatory role for angiotensin II (AII) in the central nervous system (CNS). The objectives of this research are to study the actions of AII on spontaneous activity and on Glu-induced responses in rat locus coerulus neurons. The action …
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The effects of chronic electrical stimulation of the ventromedial hypothalamic nucleus in the rat.
The purpose of this thesis was to examine more closely the changes in body growth following repeated exposure to ventromedial hypothalamic (VMH) stimulation. In the first experiment, body weight, food intake, and epididymal fat pad weight were evaluated in three groups of rats receiving either VMH …
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Freud-1, a novel regulator of the dopamine D2 and serotonin 1A receptor genes
Transcription factors that regulate the expression of neuronal genes remain incompletely understood. The focus of my research has been on the function a novel helix-loop-helix transcription factor, Freud-1, which is implicated in the regulation of the 5-HT1A receptor and is genetically linked to …
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