Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 706 for “"Biology, Microbiology"”.
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SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTION
… for the Doctor of Philosophy degree in MOLECULAR BIOLOGY, MICROBIOLOGY, AND BIOCHEMISTRY, presented on December 18, 2008, at Southern Illinois University Carbondale. TITLE: SWI/SNF-NUCLEOSOME INTERACTIONS AND DISASSEMBLY OF NUCLEOSOMES: NOVEL METHODOLOGIES FOR MAPPING PROTEIN-PROTEIN AND …
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DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION
… for the Doctor of Philosophy degree in Molecular Biology, Microbiology and Biochemistry, presented on August 22, 2017, at Southern Illinois University, School of Medicine. TITLE: DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION MAJOR …
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Analysis of heparan sulfate function during herpes simplex virus type-1 infection.
Analysis of heparan sulfate function during herpes simplex virus type-1 infection.
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Initial crystallographic and phasing studies of FlhD/FlhC complex.
Initial crystallographic and phasing studies of FlhD/FlhC complex.
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HERPESVIRUS ATELES: ISOLATION AND CHARACTERIZATION OF A HERPESVIRUS OF SPIDER MONKEYS.
HERPESVIRUS ATELES: ISOLATION AND CHARACTERIZATION OF A HERPESVIRUS OF SPIDER MONKEYS.
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DISCRIMINATION OF LIPOSOME-DELIVERED RNA BY MAMMALIAN CELLS.
DISCRIMINATION OF LIPOSOME-DELIVERED RNA BY MAMMALIAN CELLS.
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IMMUNOSTIMULATORY FUNCTIONS OF ADENOVIRIONS AND FIBER PROTEIN.
IMMUNOSTIMULATORY FUNCTIONS OF ADENOVIRIONS AND FIBER PROTEIN.
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DNA-Launched Vaccines for Emerging and Re-emerging Viral Pathogens
Given the large number and increasing frequency of viral outbreaks around the globe, there is a need to address the availability, consistency, and production of vaccines. Although there are approved vaccines for some of these diseases there are still issues that face the implementation of these …
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Dysregulated TFH cell and germinal center activation in mice with severe Orientia tsutsugamushi infection
Scrub typhus is a severely understudied tropical disease caused by Orientia tsutsugamushi. It is endemic in, but not limited to, the Asia-Pacific region, with about one million cases reported every year. Its high case fatality rates and impact during WWII and the Vietnam War justify vaccine …
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Predicting Toxin-Antitoxin Systems Responsible for Host-Induced Persistence of Burkholderia pseudomallei
Burkholderia pseudomallei (BPM) is the infectious agent that causes the disease. Melioidosis. The mortality rate for Melioidosis is up to 40% regardless of treatment. Despite the ability of certain antibiotics to reduce mortality, infection relapse occurs in 15-23% of treated patients. The …
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Cryptosporidium sp. and Giardia sp. in the St. Lawrence River: Impact on drinking water quality.
This study was designed to: (a) describe the occurrence and distribution of the protozoan parasites Cryptosporidium sp. and Giardia sp. in raw and treated water supplies on the St. Lawrence River; (b) to find a suitable microbial indicator for the presence of Cryptosporidium sp. and Giardia sp. in …
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Defining the tropism of Listeria monocytogenes using a comparative genomics approach
Listeria monocytogenes is a human foodborne pathogen capable of causing invasive and non-invasive infections. Ubiquitous in the environment, strains are often classified into lineages I (serovars 1/2a, 1/2c, 3a; food); II (containing serovars 1/2b, 4b, 3b; human illness); and III (4a, 4c; …
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Gene expression in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients Novel expression of IL-19 and IL-22 by fibroblasts
Our objective was to study gene expression related to cytokines and cytokine receptors in FLS. We were looking for any previously unidentified cytokines and receptors that may play a role in the pathogenesis of RA. Using a microarray-based approach to identify any potential expressed cytokine genes …
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Genetic and molecular characterization of origins of replication from beta-lactamase-producing plasmids of Neisseria gonorrhoeae.
This work represents a comprehensive analysis of the precise structural relationship and organization existing amongst the gonococcal beta-lactamase-producing plasmids. The second major aspect of this work deals with investigations into the genetic and molecular characterization of the multiple …
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Identification and molecular characterization of a putative heme ABC transporter in Neisseria meningitidis
A detailed mechanism for heme uptake in pathogenic Neisseriae has not yet been elucidated. Once heme is deposited in the periplasmic space, a heme dedicated ABC transporter has been hypothesized to convey heme into the cytoplasm. To address this hypothesis, we used several molecular techniques to …
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The Heme -Copper Oxidoreductase Superfamily: Genomics and Structural Analyses
In this work we characterize the sequence diversity of the heme-copper oxidoreductase superfamily by analyzing over 1100 microbial genomes (Bacteria and Archaea) and nine microbial environmental metagenomic datasets. Over 2000 new putative members were found which we classify into eight oxygen …
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Regulation of Sialic Acid Metabolism
In bacteria, sialic acids act as virulence factors for certain pathogens, and have been determined to play an important role in the establishment of many disease states. Therefore, studying the intricacies of sialic acid metabolism and its regulation provide a foundation for studying several …
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Cellular and Molecular Biological Investigations Into the Interaction Between Candida Albicans and the Vaginal Epithelium
… environment on the cellular and molecular biology of C. albicans. The first approach evaluated the expression of the eight agglutinin-like sequence (ALS) genes in clinical vaginal specimens and in models of vaginal candidiasis, including a murine model and an in vitro tissue model. The ALS …
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Fatty Acid-Mediated Inhibition of Host Cell Invasion by Cryptosporidium Parvum
We have purified from bovine colostrum digests an unsaturated fatty acid that inhibits Cryptosporidium parvum sporozoite invasion of host cells in vitro. A panel of similar lipids with varying chain lengths and degrees of saturation were tested for evidence of inhibitory activity in order to …
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Ascomycetes From North Temperate Lakes in Wisconsin
A comprehensive study of freshwater ascomycetes in seven lakes in northern Wisconsin was carried out. These lakes are part of the Long Term Ecological Research (LTER) project and have been the subject of limnological studies since the early 1900's. Our knowledge of freshwater ascomycetes is fairly …
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