Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 562 for “"Biology, Genetics."”.
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An approach to the requirements for active management of different elements in New Zealand avifauna: Presented in partial fulfilment of the requirements for the Degree of Masters of Science in the University of Canterbury
… vulnerability to extinction that uses population biology, genetics, and modelling is outlined. These criteria also provide a classification of New Zealand birds and a framework for further research. Some initial criteria are drawn up, further development that is necessary of these criteria are …
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Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis
… has revolutionized the study of molecular biology, genetics and developmental biology enabling delineation of biological processes in unprecedented details. Through the study of epigenetics and posttranscriptional regulation of gene expression by high-throughput sequencing technologies in …
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Characterization of the Arabidopsis thaliana Auxin F-Box Family Members AFB4 and AFB5
… AFB4 and AFB5. Using a combination of molecular biology, genetics and biochemistry I have begun the characterization of these two proteins plant development and their possible function as auxin receptors. While both proteins are clearly involved in auxin response, AFB4 has a more pleiotropic role …
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Expanding the genetic toolbox for methanogenic archaea and investigating ferredoxin redox circuit formation in Methanosarcina acetivorans
… has been made to understand methanogen cell biology, genetics, physiology, and metabolism, much remains unknown about these fundamental attributes. The work presented in this Thesis addresses some of these aspects. In Chapter 2, I report the finding that a single ferredoxin is the primary …
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Integrative Approaches in Genomic Analysis: Advancing Epigenetic Prediction, Twas Methodology, and Cell-Type Deconvolution in Spatial Transcriptomics
In the rapidly evolving world of molecular biology, genetics and epigenetics have taken crucial roles in unraveling the complex origins of diseases. Through gene expression, genes govern the synthesis of proteins, the fundamental building blocks of life. Conventional observational studies grapple …
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Deciphering Functional Significance of Substrate-Binding Domain of Ssa1 on Heat-Shock Response and Prion Propagation
… yeast system and a combination of computational biology, genetics, structural biology, biochemistry and molecular biology were utilized to decipher the role of the SBD of Hsp70 in regulation of heat shock response and [PSI+] prion propagation. It was found that mutations (F475S and L483W) located …
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Computational Morphogenesis of City Tissues
… such as systems theory, complexity science, genetics, developmental and evolutionary biology. The discoveries had a profound impact in understanding the nature of cities as they develop over time. Once considered top-down models in equilibrium, the dynamic qualities of cities could be …
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How the Heart Grows: From Multi-scale Data to a Multi-scale Model
… disciplines. Many groups have studied the biology, genetics, and mechanical processes during heart looping. These studies have been carried out at different levels of subcellular, cell, tissue, and organ. However, looping is a very complex process and, despite a great deal of experimental …
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Investigation into the genetic nature of familial congenital bicuspid aortic valve
Bicuspid aortic valve (BAV) affects approximately 1% of the general population and its etiology remains unknown. Based on literature reports, we hypothesized that congenital BAV (cBAV) was a developmental defect inherited as an autosomal dominant trait with variable penetrance. We evaluated the …
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Isolation and characterization of motility-defective mutants of Haloferax volcanii.
Haloferax volcanii is a motile extreme halophile, and a detailed physical map of its genome exists. An effort is underway to locate more genes and to increase the detail of this map. Flagellated motile bacteria possess a number of filaments that function as cellular propellers. Motile bacteria swim …
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Characterisation of a conserved motif found within the Dlx cis-regulatory element URE2 and its effect on mouse URE2-lacZ activity in transgenic mice
The Distal-less-like genes, commonly referred to as Dlx genes, encode homeodomain transcription factors essential for the establishment of GABAergic interneurons in the ventral forebrain as well as their migration to the cortex. The cis-regulatory element URE2 (enhancer) is located upstream of Dlx1 …
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Investigation of the Molecular Mechanism for Cerebral Cavernous Malformations
<p>Cerebral cavernous malformations (CCM) are vascular anomalies of the central nervous system comprised of grossly-dilated blood-filled capillaries. CCM leisons may occur sporadically or by inheritance of a mutation in one of three genes, <italic>CCM1</italic>, <italic>CCM2</italic>, or …
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The Role of Genomic Sequence in the Spatial and Temporal Propagation of Heterochromatin
<p>Characterizing how genomic sequence interacts with trans-acting regulatory factors to implement a program of gene expression in eukaryotic organisms is critical to our understanding of genome function. One means by which patterns of gene expression are achieved is through the differential …
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Development of a Genetic Linkage Map of Broccoli and Identification of QTL Associated With Glucosinolate Variability
The third experiment then demonstrates how the broccoli genetic linkage map can be used to identify genetic factors affecting qualitative and quantitative differences in health promoting compounds. QTL analysis in this experiment identified seven QTL on six linkage groups associated with the …
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Epistasis and Other Factors Influencing the Detection of Marker-Qtl Associations
Marker-QTL associations over two breeding cycles in a sweet corn pedigree breeding program were tested. Eight and six marker loci associated with QTL influencing field emergence and eating quality uncovered in previous studies were subjected to a second cycle of pedigree breeding. Only two of the …
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The Phylogenetic Relationships Among Extant Catfishes, With Special Reference to Ictaluridae (Otophysi: Siluriformes)
Cytochrome b suggested cryptic diversity within several species of Noturus. Relationships among members of the subgenus Rabida were resolved and in many cases well supported. Relationships among Schilbeodes were poorly resolved. A calibrated substitution rate identified a period between 8 and 2 …
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Taxonomy of the Neotropical Thorny Catfishes (Siluriformes: Doradidae) and Revision of Genus Leptodoras
Cladistic analysis of relationships among Leptodoras and related taxa (Anduzedoras, Doras, Hassar, Hemidoras) using morphological data recovers Leptodoras praelongus (Myers & Weitzman) as the most ancestral species. The most derived clade is composed of two nominal species, Leptodoras juruensis …
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The Role That Asexual Reproduction Plays in the Regeneration of Tropical Piper Shrubs: Habitat Differences and Genetic Consequences
Asexual reproduction is a common, but little explored characteristic of many tropical plants with a variety of life-histories and habitat requirements. My dissertation research examined the ecological correlates and population genetic consequences of asexual reproductive success in five …
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"Physiological and Molecular Analysis of Dnd ""Defense, No Death"" Mutants of Arabidopsis"
"Plant diseases cause billions of dollars in damage to crops annually, making dissection of the molecular mechanisms of plant disease resistance an economically important task. Gene-for-gene resistance mediated by plant R genes and pathogen avr genes has long been associated with the hypersensitive …
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Population Genetics of Sabatia Campestris (Gentianaceae), a State-Endangered Plant of the Illinois Prairie
Population genetic structure of peripheral populations of S. campestris from Illinois was investigated both within Illinois and at a regional scale. The results identified isolation by distance patterns indicating that Illinois populations differed genetically from central populations that were …
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