Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"Biology, Cellular"”.
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A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, yet the metabolic mechanisms that underlie its initiation and progression remain poorly defined. Mitochondrial metabolism, particularly the function of respiratory complex I, has emerged as a key determinant of …
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Identification of Metabolic Markers as Potential Early Predictors of PFAS- Induced Immunotoxicity
Since the 1940s, industries and consumer products have utilized manufactured chemicals known as per- and polyfluoroalkyl substances (PFAS). They can be found in consumer products such as clothing, food packaging, cookware, cosmetics, carpet, and fire-fighting foam. PFAS are often referred to as …
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Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
… creating reactive oxygen species that cause intracellular damage that ultimately brings about cell death. Photodynamic therapy (PDT) has the advantage over contemporary cancer treatment methods in that it is both non-invasive and can be tailored to largely avoid damage to noncancerous cells. The …
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In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia
Resveratrol has been shown to have cancer preventive properties. It modulates a wide range of molecular targets including those involved with induction of apoptosis and cell cycle arrest in a concentration dependent fashion. This study was designed to investigate resveratrol's ability to reduce …
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Exploring the Role of PANNEXIN1A in an Acute Experimental Model of Parkinson's Disease
In the nervous system Pannexin1 channels are major ATP and glutamate release sites. The channels are implicated in neurodegenerative disorders including Parkinson’s disease, but the underlying mechanisms remain unclear. Here, an interdisciplinary approach tested roles of the mammalian Pannexin1 …
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Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
Ferroptosis, an iron-dependent non-apoptotic cell death involves lipid peroxidation and associates with cardiometabolic disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the …
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Decoding Gating Properties of the Pannexin1 Channel: ATP Release and pH Sensitivity and the Potential Role in Health and Disease
… Since epileptic and ischemic events cause extracellular pH changes, the role of Panx1 in pH sensing was explored next. In a cell model Panx1 showed pH dependent channel gating properties. Site directed mutagenesis and high throughput dye uptake tests revealed a conserved domain of the protein as …
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Characterization of RYamide neuropeptides and their Receptor in the Disease Vector Mosquito, Aedes aegypti
Insects utilize neuropeptides to fine-tune their physiological systems, including the tissues and organs involved in excretion, respiration, reproduction, and metabolism. The focus of this study is on the recently identified RYamide insect neuropeptides, named for the arginine-tyrosine amidated …
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Regulation of the Tubulin Homolog FtsZ in <i>Escherichia coli</i>
<p><em>Escherichia coli</em> is a well-known pathogen, and importantly, a widely used model organism in all fields of biological sciences for cloning, protein purification, and as a model for Gram-negative bacterial species. And yet, researchers do not fully understand how this bacterium replicates …
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Identification, localization and metal-catalyzed induction of specific metallothionein isoforms expressed by the adult human lens
Purpose. Metallothioneins (MT s) are a large family of proteins involved in multiple protective pathways, including binding of toxic metals and oxidative stress. Previously we detected increased expression of MT IIA in age-related human cataractous lenses. As a first step towards defining the …
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Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin
The hair cell of the inner ear converts mechanical stimuli, such as sound waves, into electrical impulses which are then sent to and interpreted by the brain. Proper organization of the actin and microtubule cytoskeletons is important for establishing the distinct morphology of the hair cell, which …
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Studies of the mammalian ovarian endothelin system
In porcine ovaries, endothelin-1 (ET-1) may have an autocrine/paracrine role in follicular development. Endothelin-converting enzyme-1 (ECE-1) converts big endothelin-1 to ET-1. In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in …
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Understanding The Pathogenesis of Renal Medullary Carcinoma
<p>Renal medullary carcinoma (RMC) is a lethal cancer that predominantly affects young individuals with sickle cell trait (SCT). It is not currently understood why RMC only affects certain individuals with SCT. We found that patients with RMC more frequently participated in high-intensity exercise …
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