Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 496 for “"Biology, Cell"”.
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Drosophila melanogaster as a high-throughput and in vivo model to study body weight and feeding behaviour
… is a key model for research in developmental biology, cell biology and neurobiology, and has also recently been demonstrated to be an excellent model for dissecting metabolic homeostasis pathways. In this thesis, a suite of assays was developed in Drosophila to examine changes in the state of …
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Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
Immunomodulation of dendritic cells in autoimmune type 1 diabetes mellitus.
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A role for myosin in the regulation of mammalian nonmuscle cell motility.
… myosin in the regulation of mammalian nonmuscle cell motility.
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Self-renewal of human bone marrow-derived hematopoietic stem cells in vitro.
… of human bone marrow-derived hematopoietic stem cells in vitro.
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A novel function of enteropathogenic Escherichia coli secreted protein F within intestinal epithelial cells.
… secreted protein F within intestinal epithelial cells.
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The roles of the retinoic acid receptors in growth, differentiation and development.
… acid (RA) induced differentiation of P19 cells. I used mutant RARs to block the normal differentiation of these cells and then analyzed the possible mechanisms by which these mutants are able to exert such effects. My results indicate that overexpression of a dominant negative RAR …
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Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… system in high-glucose treated (HG)-mesangial cells (MG) and streptozotocin (STZ)-diabetic rat kidneys. In situ hybridization, RT-PCR, RealTime RT-PCR, and Northern blot were used to study mRNA, and immunohistochemistry and Western blot for protein. IP mRNA was detected in glomeruli, …
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Short-term recovery from a volume increase in the mouse zygote: Characteristics of regulatory volume decrease in vitro.
… osmolyte channel like that found in many other cells. A method developed by Passantes-Morales et al. (1993) was used, in which a large extracellular concentration of one of a number of organic osmolytes was added to the experimental media, and the ability of the zygote to perform RVD in the …
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Investigation of a ribosomal RNA operon of Frankia sp. strain AcN14a.
With the aim of increasing our plant knowledge of Frankia, we have investigated the structure of the ribosomal RNA genes from Frankia sp. strain AcN14a. A genomic library was constructed in EMBL3 and two types of clones, each containing a different set of rRNA genes, were identified by restriction …
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Inquiries into the subcellular localization of the glucocorticoid receptor.
… assay was employed to characterize the subcellular localization of a series of GR mutants effectively truncating, deleting or mutating specific regions of the receptor N-terminus. In the first part of my study, I delimited a specific region of GR (amino acids 100--200 of the N-terminus) …
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Unique localization of protein kinase C isozymes in T51B rat liver cells and their role in proliferation and apoptosis.
The regulation of cell proliferation and apoptosis in T51B rat liver cells has been investigated. These cells have proven to be an excellent in vitro model for cellular homeostasis since growth stimulation by re-addition of serum or epidermal growth factor (EGF) induces an initial burst of cell …
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Role of Xenopus p21-activated kinase 2 (X-PAK2) in polar body formation during oocyte maturation
Vertebrate oocytes are physiologically arrested in meiotic prophase until shortly before ovulation. Under the influence of gonadotropic hormones, these oocytes resume meiosis and progress to metaphase II, in which they await fertilization. The transition from prophase to metaphase II is termed …
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Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development.
… mitogenic actions of TGF$\alpha$ on granulosa cells during follicular development, as well as its involvement in the regulation of urokinase plasminogen activator, an enzyme playing an important role in tissue remodelling. Granulosa cells from the first (F1), fifth, and sixth (F5-6) largest …
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Insulin and TSH signal transduction pathways in human preadipocytes.
… on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal expansion. We demonstrate that rapamycin inhibits the differentiation of human preadipocytes in primary culture, even though these cells do not undergo clonal expansion. …
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The cloning and characterization of the TIK kinase.
… which plays a central role in a wide variety of cellular functions. The ready reversibility of the phosphotransfer reaction makes it well-suited for rapid cellular responses, such as the responses to signals from extracellular stimuli. Members of the protein kinase family have been identified as …
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Calcium, actin and the spectrin skeleton: Responses to swelling and shrinking perturbations.
It was postulated that cells regulate their surface membrane in response to membrane tension gradients. Increases in membrane tension, brought about by swelling, should therefore elicit addition of membrane to the cell surface, whereas decreases in membrane tension, brought about by shrinking, …
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INVESTIGATING POST-TRANSCRIPTIONAL REGULATION OVER MRNA FATE ACROSS THE MITOTIC-TO-MEIOTIC TRANSITION IN MALE GERM CELLS
… mRNA utilization throughout male germ cell development. Although it is recognized that post-transcriptional control of mRNAs is essential for spermatogenesis, little is known regarding how differential utilization of mRNAs results in successful entry of male germ cells into meiosis. The …
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Regulation of Adaptive Immunity in the Lung by the Alveolar Epithelial Type II Cell and Surfactant Protein a
… or asthma. The alveolar epithelial type II cell and its secretory product, surfactant protein A (SP-A), have been linked to roles in adaptive immunity in the lung. The discovery that type II cells constitutively express major histocompatibility complex class II (MHC II) suggested that type …
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Nkx3.2 regulates zebrafish vascular stabilization through recruitment of mural cells
… development where the immature endothelial cell tube gains structural support through the recruitment and adhesion of perivascular mural cells; pericytes and vascular smooth muscle cells (vSMC). When vessels are not well supported by mural cells hemorrhage can occur. Nkx3.2 deficient …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… (Stat5) regulated gene in breast cancer cells. We have now observed that prolactin increased the viability of breast cancer cells to DNA damaging chemotherapeutics, and Hsp90 inhibitors, 17AAG and BIIB021, abrogated the effect of prolactin, indicating the mechanism of enhanced viability …
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