Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 72 for “"Biology, Bioinformatics"”.
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Study of the role of plant nuclear envelope and lamina-like components in nuclear and chromatin organisation using 3D imaging
… in this thesis associate genetics, molecular biology, bioinformatics and imaging to better understand the contribution of the nuclear envelope in nuclear morphology and chromatin organisation and suggests the functional implication of the LINC complex in these processes.
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Functional discovery in the oxidative D-galacturonate assimilation pathway and development of the enzyme similarity web tool
… EFI labs include those with expertise in bioinformatics, computational biology, structural biology, enzymology, and biology, that work together to develop a systematic approach that starts with using bioinformatics to select enzyme candidates for structural elucidation, ligand docking to …
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Machine learning in bioinformatics: Algorithms, implementations and applications.
Machine learning in bioinformatics: Algorithms, implementations and applications.
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Bioinformatics of High Throughput Proteomics Using Tandem Mass Spectrometry of Intact Proteins
Top down mass spectrometry is a unique approach to the problem of identifying and characterizing proteins with a DNA-predicted sequence. It would be desirable to move top down mass spectrometry in to the 'omic' sciences by developing a high throughput form that could be used to simultaneously …
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Microarray Analysis of Soybean Treated With Fusarium Toxin and Development of a Soybean Gene Expression Database
Sudden death syndrome (SDS) of soybean is a devastating disease caused by the soilborne fungus Fusarium solani sp. glycines (Fsg) that limits maximum yield potential. SDS is of increasing concern in the United States because it continues to spread into important soybean production areas. Yield …
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Bioinformatics and Mass Spectrometry for Neuropeptide Characterization
The methods employed for the discovery of neuropeptide genes and gene products in insect, echinoderms and chordates along with neuropeptide processing predictors present generalized and successful approaches for neuropeptide discovery in any organism.
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The Discovery and Evolutionary Analysis of Divergent Homologs Involved in Cattle Immune and Reproductive Biology
Ten divergent homologs were identified using a subtractive bioinformatic analysis of 12,614 cattle placenta ESTs followed by comparative, evolutionary and gene expression studies. Eight have not been identified previously. These were named: CSSMST1, CIST1, HAVCRNDP, PRP8, PRP9, PRP11, SECTM1A and …
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In Vitro Selection and Characterization of Catalytic DNA in Model Biological Systems
This research also details the first attempt to obtain useful information from heterogeneous DNA sequencing data. A sample of the selection population from each of the twelve rounds of in vitro selection was heterogeneously sequenced without any prior separation or purification. The observed …
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Global Optimization in Systems Biology and Bioinformatics
Identification of transcription factor binding motif and sites is a crucial effort to elucidate gene regulatory networks and its combinatorial problem is NP -hard. In this thesis, the problem is modeled as an integer linear program with weak assumptions on the binding pattern. A computationally …
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Phenomenological Approaches to the Analysis of High-Throughput Biological Experiments
We have also discussed various methodological issues faced in the analysis of high-throughput experiments. In particular, novel methods for noise removal and for visualization are presented.
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Genomic Cis-Regulatory Map Mining.
Genomic Cis-Regulatory Map Mining.
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Single Cell RNA Sequencing Data Analysis and Applications in Caenorhabditis Elegans Embryo Development
Single cell RNA sequencing (hereinafter “scRNA-seq”) has become a routine assay in molecular biological research, allowing in-depth assessments of individual cell transcriptome. Here, we used scRNA-seq datasets to study the global cellular communications in the Caenorhabditis elegans (hereinafter …
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Assessing the Mutational Landscape of BRAF- and KRAS-Wild Type Colorectal Cancer
Colorectal cancer is one of the most deadly cancers and is the second leading cause of death in the United States. As incidence of colorectal cancer is higher among developed countries, research continues in hopes to make marked advancements in the way cancer is treated. A number of targeted …
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Sequence features affecting translation initiation in eukaryotes: A bioinformatic approach
Sequence features play an important role in the regulation of translation initiation. This thesis focuses on the sequence features affecting eukaryotic initiation. The characteristics of 5' untranslated region in Saccharomyces cerevisiae were explored. It is found that the 40 nucleotides upstream …
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Genome Rearrangements: Structural Inference and Functional Consequences
As genomes evolve over hundreds of millions years, the chromosomes become rearranged, with segments of some chromosomes inverted, while other chromosomes reciprocally exchange chunks from their ends. These rearrangements lead to the scrambling of the elements of one genome with respect to another …
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Neuropeptidomics Across Metazoan Life
Every neuron in our brain is bathed in a sea of diverse signaling molecules, including peptides. It is well known that neuropeptides, acting as neurotransmitters, neuromodulators and peptide hormones, play pivotal roles in a variety of physiological processes, such as learning and memory, sleeping, …
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Extracellular Vesicles as Mediators of Communication Between Endothelial Cells and Fibroblasts
During tissue repair, the peak of angiogenesis is characterized by dense, disorganized and poorly perfused vasculature. As healing progresses, many newly formed vessels regress while surrounding fibroblasts undergo robust proliferation and matrix remodeling. Although fibroblast activation often …
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Efficient Identification and Comprehension of Molecular Pathways Associated with Irradiation Induced Hepatic Carcinogenesis
As human exploration into deep space continues to expand in the future, risk prediction for irradiation-induced diseases will become an increasingly important task. It will be critical to identify the biological effects of high-charge, high energy (HZE) and low energy 137Cs γ rays, which are the …
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Study of Enzyme Evolution Within the MLE Subgroup Focusing on Characterizing Member Enzymes for the Purpose of Discovering Relationships Among Sequence, Structure, and Function
… of protein function assignment in the field of Biology and will promote advances in understanding the relationship between function and structure of proteins in science.
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