Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1032 for “"Biological processes"”.
-
Modeling structured biological processes with machine learning
… directly applying such methods to model complex biological processes can fail to yield models with causal understanding. It would be desirable to build models that combine the rich bodies of causal knowledge built over decades of research with modern flexible machine learning methods that scale …
-
Refinement and Applications of Light Controlled Biological Processes
For understanding of biological processes, a spatiotemporal control over these processes is needed. Controlling these processes using light can give us the advantage of a precise control over spacing, timing and degree of biological functions. Thus, biological processes can be turned on/off using …
-
Stochastic and physical modeling of fundamental biological processes
… data generated from quantitative experiments on biological systems. It combines our knowledge of a phenomenon into a succinct mathematical or computational description. In this dissertation, we first describe briefly two applications of modeling in biophysics: loading of the replication clamp …
-
Understanding the biological processes underpinning neurodegeneration in Xeroderma Pigmentosum
… In this thesis, I set out to understand the biological processes underlying neurodegeneration in XP. I studied multiple patients from a variety of complementation groups using a human induced pluripotent stem (hiPSC) model. Functional multi-omic characterisation at several stages of the …
-
Discovering contextual connections between biological processes using high-throughput data
… to reporting the collective perturbation of biologically-related collections of genes, or "processes". Recent expression analysis methods have focused on improving comprehensibility of results by reporting concise, non-redundant sets of processes by leveraging statistical modeling techniques …
-
Physical and biological processes at the Middle Atlantic Bight shelf-break front
… observed within the centers of both eddies. Biological enhancement within each eddy was observed, which may have been a result of advection from source waters and/or a local response to upwelled nutrients. The influence of frontal variability and frontal eddies on nutrients and plankton at …
-
Detecting Phenotype-Specific Interactions Between Biological Processes From Microarray Data And Annotations
… levels on a genomic scale. Correct and efficient biological interpretation of the voluminous data generated by these technologies, however, remains a challenging problem. A commonly used approach in interpreting the results of such high throughput experiments is to map the list of differentially …
-
Physical and Biological Processes at the Middle Atlantic Bight Shelf-Break Front
… observed within the centers of both eddies. Biological enhancement within each eddy was observed, which may have been a result of advection from source waters and/or a local response to upwelled nutrients. The influence of frontal variability and frontal eddies on nutrients and plankton at …
-
Understanding the physical, chemical and biological processes across the subtropical convergence during austral automn
… was to investigate the physical, chemical and biological dynamics of the Subtropical Convergence (STC), in the SW Indian sector of the Southern Ocean. Satellite data was obtained and in-situ data were collected. Mixed layer depth (MLD), geostrophic velocities, density and Brunt Vaisala …
-
Physical Control of Biological Processes in the Central Equatorial Pacific: A Data Assimilative Modeling Study
… in order to investigate the effects of physical processes encompassing a wide range of space and time scales, on the lower trophic levels of the highly dynamic central equatorial Pacific (140°W). Many of the biological processes included in the ecosystem model respond to environmental …
-
Methods for increasing model accuracy and simulation time scales of biological processes with molecular dynamics
… time scales, which are typical of diffusive processes. This collection of projects is a snapshot of the diversity and versatility of current problems in structural biology that can be addressed by molecular dynamics simulations. I hope to instill in the reader a sense of how method …
-
Complexity as a Form of Transition From Dynamics to Thermodynamics: Application to Sociological and Biological Processes.
… the statistical mechanical foundation of complex processes. These processes are characterized by a delicate balance of randomness and order, and a correct paradigm for them seems to be the concept of sporadic randomness. First of all, we have studied if it is possible to establish a foundation of …
-
Interactions Between Heterotrophic and Autotrophic Bacteria in Fixed-Film Biological Processes Used in Drinking Water Treatment
Biological nitrification in water treatment is largely used in Europe to remove ammonia before the final disinfection step. In order to simulate this process in the laboratory, a scaling procedure for biofilm processes was developed and evaluated. Experiments conducted with these laboratory-scale …
-
A tale of two microbes: Computational investigations of biological processes in escherichia and methanosarcina at multiple scales
Biological phenomena, while grounded in the laws of physics and chemistry, often exhibit behaviours too complex to be ascribed to a single electron density, bond vibration or chemical reaction. Rather, the processes inherent to living organisms---adaptation, growth, homeostasis, metabolism, …
-
Shedding light on the molecular interactomes of fast, complex biological processes using multispectral imaging with uncompromised spatiotemporal resolution
… nature of fundamental intracellular processes. However, despite these advances, due to the broad emission spectra of conventional fluorophores only three or fewer fluorescently-labelled structures can be observed in live cells using the majority of microscopes, which is far fewer than …
-
Simulation studies of the structure-function relationship of two biological processes: proton pumping in cbb3 oxidase and activation of Parkin
… of biomolecular systems by describing molecular processes at different levels of resolution and playing an important role in chemistry, biology and physics. In this work, several computational techniques – standard and enhanced sampling MD simulations, multi-conformational pKa calculations and …
-
The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
… of functionalised stapled peptides for two biological applications. 1. The development of stapled peptides as chemical tools to investigate PPIs in human platelets Platelets are a vital, anuclear component of blood. The Bcl-2 family of proteins are known to be key mediators of apoptosis in …
-
Computational investigations into two biological processes: membrane reshaping by light-harvesting proteins in the chromatophores of purple bacteria, and oligomerization and pore formation by the Hepatitis C viroporin p7
… dissertation presents research on two different biological systems: (1) the light-harvesting proteins in the chromatophores of purple photosynthetic bacteria, and (2) the structure and function of the Hepatitis C viroporin p7. Purple photosynthetic bacteria form membranous pseudo-organelles …
-
Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis
… developmental biology enabling delineation of biological processes in unprecedented details. Through the study of epigenetics and posttranscriptional regulation of gene expression by high-throughput sequencing technologies in several biological processes, namely embryonic stem cells, somatic …
Page 1 of 52