Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Biological models"”.
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A tool for automated inference in rule-based biological models
Rule-based biological models help researchers investigate systems such as cellular signalling pathways. Although these models are generally programmed by hand, some research efforts aim to program them automatically using biological facts extracted from papers via natural language processing. …
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The Application of the Expectation-Maximization Algorithm to the Identification of Biological Models
… researchers have turned their attention toward biological process modeling and system identification. The abundance of data available, while inspiring, is also daunting to interpret. Following the initial work of Rangel et al., we propose a linear model for identifying the biological model …
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Duration, density, and evolutionary form : application of biological principles to architectural surface
… of organic and evolutionary form. When these biological models are coupled with computational power, architectural design can begin to address the dimension of time. By dealing with the concept of duration, architecture reaches levels of complexity that match the world in which it exists. This …
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Uncertainty Analysis of Biological Nonlinear Models Based on Bayesian Estimation
… based on realistic distribution for nonlinear models, especially biological models. Parameter estimation, random number generation, and uncertainty analysis are closely related in Monte Carlo simulation based model assessment. All three aspects are discussed in this study. Because of the …
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A biological model of object recognition with feature learning
Previous biological models of object recognition in cortex have been evaluated using idealized scenes and have hard-coded features, such as the HMAX model by Riesenhuber and Poggio [10]. Because HMAX uses the same set of features for all object classes, it does not perform well in the task of …
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Memristive Devices For Neuronal Systems
… learning in brains and how we can build up non-biological systems, which function similar to those. In particular, I focused on the usage of new non-volatile memory technologies and electronic circuits for neuromorphic systems. Thus, the development of non-volatile devices and electronic …
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Representation and visualization of genetic regulatory networks
… the interactive visualization of large, complex biological models that are represented as graphs. Sonnet provides a flexible representation framework and graphical user interface for filtering and layout, allowing users to rapidly visualize different aspects of a data set. Many previous …
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Accelerating Finite State Projection through General Purpose Graphics Processing
… by several orders of magnitude. Specific biological models and modeling techniques are discussed as a demonstration of the algorithm implemented on a general purpose graphics processor. The results of this work show that general purpose graphics processing will be a key factor in modeling …
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It's about time : temporal representations for synthetic characters
… computational systems, but its derivation from biological models suggests that it may also be useful for gaining a new perspective on learning in biological systems. The implementation of a complete character built using this architecture is able to reproduce a variety of conditioning phenomena, …
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fMRI detection with spatial regularization
… with our understanding of brain activation. The biological models of brain activation suggest that adjacent locations of the brain tend to be in the same activation state. We take advantage of these models and apply a Markov Random Field (MRF) spatial prior to the statistics provided by the …
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Characterization of Gene-by-Age Interaction and Gene-by-Gene Interaction In Coronary Artery Disease
… been limited by missing heritability and lack of biological relevance of identified variants. We sought to address these issues by characterizing interaction among genotypes and environment using case-control samples enrolled at Duke University Medical Center. First, we studied the impact of age …
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Engineering human hepatic organoids for in vitro liver modeling and implantable cell therapies
… primary cells in 3D, generating valuable biological models and offering a new source of healthy cells for regenerative medicine. Here, we describe establishment of organoid culture systems for human hepatic cells and demonstrate their utility for in vitro modeling and liver tissue …
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Mapping and modeling macrophages in tuberculosis
… these states using ex vivo-generated macrophage models. To extend these findings, we identify conserved gene programs underpinning macrophage states across other lung diseases in humans. Similarly, we then describe macrophage and other immune cell states after Bacillus Calmette–Guérin (BCG) …
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Imitation of atypical biological motion in autism spectrum disorders
… the present thesis was to examine imitation of biological motion in adults with autism spectrum disorders. Using a novel behavioural protocol, adults with autism and matched neurotypical control adults imitated models that displayed distinctly different, but biological believable kinematics. In …
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VANESA - A bioinformatics software application for the modeling, visualization, analysis, and simulation of biological networks in systems biology applications
… natural sciences in the modeling and analysis of biological systems to better understand biological processes. Therefore, it combines different fields of research, such as information fusion, modeling, analysis, simulation, and network visualization, which are some of the most important areas in …
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The Subjecthood of Slime Mould: modelling single-celled intelligence through living systems art
… a material, relational and behavioural model – a biological analogue which, through the creation of artworks and experiences, provides a means of accessing nonhuman imaginings and speculative subjectivities. Slime mould ‘modelled’ in artistic contexts, it is argued, can help us attune to the …
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Multilineage modelling of early placental responses to pathogens at single-cell resolution
… infections using in vitro and ex vivo placental models such as human trophoblast stem cells (hTSCs), organoids, and placental explants, and perform a comprehensive single-cell transcriptomic analysis of their responses. Firstly, I outline the physiological structure and role of the placenta in …
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