Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 140 for “"Biological Pathways"”.
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New Biological Pathways
… by using microscopic – often designed – biological components, allowing biology to conduct highly specialized forms of work previously unseen in nature. In this thesis, I propose and develop three new biological pathways which can perform three different categories of work i) information …
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Exploiting biological pathways to infer temporal gene interaction models
… for each gene, and the complexity of biological networks. We focus instead on the B cell receptor (BCR) signaling pathway, which narrows the inference problem and provides a clinical application, as B cell chronic lymphocytic leukemia (B-CLL) is believed to be related to BCR response. …
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Network Analysis to Identify Biological Pathways Associated with Lyme Disease
… and enrichment analysis to identify potential pathways of interest generating novel hypotheses for the underlying mechanisms of LD. I identified specific T-Cell-based inflammatory, arthritic and neurological pathways that were significantly elevated in LD patients and other elevated pathways …
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Caged phosphopeptides and phosphoproteins : agents in unraveling complex biological pathways
Within cellular signaling, protein phosphorylation is the post-translational modification most frequently used to regulate protein activity. Protein kinases and phosphoprotein phosphatases generate and terminate these phosphoryl signals, respectively. Chemical approaches for studying protein …
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Multi-omics Data Integration for Identifying Disease Specific Biological Pathways
… the investigation on disease relevant pathways. Although much work has previously been done to explore the single omics data, little work has been reported using multi-omics data integration, mainly due to methodological and technological limitations. While a single omic data can …
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Analysis of biological pathways, associated with orthodontic force, using multiplex arrays
Objective - investigate tissue changes induced by orthodontic forces at tension and compression sites. Methods - Gingival Crevicular Fluid (GCF), was collected from maxillary canines and second molars from volunteers (n=21), before appliance placement and tooth extraction (B); 3 months into …
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Informatics Approaches to Linking Mutations to Biological Pathways, Networks and Clinical Data
… the project is to link genetic variation data to biological pathways and networks data, and also to clinical data for creating a framework for translational and systems biology studies. The study of the interactions between the components of biological systems and biological pathways has become …
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Leveraging biological pathways and gene networks to understand the genetic architecture of diseases and complex traits
Recent studies have highlighted the role of biological pathways and gene networks in disease biology. In this thesis, we formally assess (1) the contribution of disease-associated gene pathways to disease heritability, (2) the contribution of genes with high network connectivity in known gene …
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Data-driven and Machine Learning approaches for exploration and inference of Biological Pathways in physiological and pathological states
… a vast and dynamic cellular interaction network. Biological pathways are used in an attempt to model this network. These pathways play a key role in advancing our understanding of cellular processes and are employed across a wide range of tasks. The utility of pathways is demonstrated in the first …
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Methods for the estimation and application of biological networks
The advent of high-dimensional biological data from technologies like microarrays and mass spectrometers has transformed both biology and statistical theory; however, the tremendous potential of these datasets to explore the interactive behavior of genes or proteins has been largely unexplored. …
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Interpreting the role of non-coding genetic variation in human disease
… profiles, gene regulatory circuitry, and biological pathways. We first develop a method to simultaneously select relevant genomic regions not yet associated with disease as well as select relevant functional annotations enriched in those regions. We show that both tissue-specific and …
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Computational methods to dissect the genetic basis of human disease
… genetic variants. However, the path from GWAS to biological insight remains challenging, notably in identifying relevant biological pathways, explaining mechanistic links between diseases, and nominating disease-critical tissues and cell types. In this thesis, I introduce computational methods to …
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Towards a Comprehensive Human Pathway Database For Systems Biology Applications
A biological pathway is a series of reactions and molecular interactions. Pathway information provides a blueprint for biomedical researchers to devise new treatment and diagnostic solutions for human diseases. Pathway data are publicly available in many databases. Most of the databases however …
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Proteomic approaches for the identification of biomarkers of beef tenderness from Longissimus thoracis muscles and plasma of young Limousin-sired bulls
… mechanisms lying behind the biomarkers and the biological pathways involved. The work in this thesis firstly assessed the feasibility of RNAlater® as a muscle protein preservation method to facilitate discovery of biomarkers of multiple beef quality traits by proteomic approaches in plasma and …
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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
… identify and characterize alterations in known biological pathways. I report that deletion of nGLT-1 results in a high degree of differential gene expression within CA3 (1509), CAl (322), and Striatum (1268). Furthermore, these alterations in gene expression were enriched in annotated biological …
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A Fragile Native State Structure: An Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Variant Exhibits Slow Interconversion Kinetics Between two Different Folds
… (bHLH-PAS) protein that controls various biological pathways by forming heterodimeric transcriptional regulator complexes with several other bHLH-PAS proteins via the beta-sheet surfaces of its two PAS domains. The beta-sheets of PAS domains are involved in many intermolecular interactions …
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Functionalization and Modification of Naphthaquinone Analogs as HER2 Kinase Inhibitors
… auto-phosphorylation. This process controls biological pathways that mediate the cell growth. In normal cells this process is highly controlled. We are targeting the modification of the side chain of the hydroxy methyl group of 2-Hydroxy methyl-5,8-dimethoxy-1,4-naphthaquinone. These …
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EXPANDING THE TOOLKIT: STRUCTURE, DYNAMICS, AND DRUG INTERACTIONS OF THE “PRIMING LOOP” FROM HEPATITIS B VIRUS PRE-GENOMIC RNA BY SOLUTION NMR SPECTROSCOPY
… that function as essential components of biological pathways that result in human disease, making them attractive therapeutic targets. Yet, RNA structural biology lags significantly behind that of proteins, limiting mechanistic understanding of RNA chemical biology. Fortunately, solution …
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Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules
… for identification of cancer-type specific biological pathways, and optimized versions of these small molecules have potential in targeted anti-cancer therapy.
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Comparative Functional Genomics Characterization of Low Phytic Acid Soybeans and Virus Resistant Soybeans
… studies provide a wealth of information on the biological dynamics underlying phenotypes. Though functional genomics approaches are used extensively in human disease research, their use also spans organisms as miniscule as mycoplasmas to as great as sperm whales. In particular, functional …
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