Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Biological Experiments"”.
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Image processing for biological experiments on a mobile phone
… CMOS camera as a sensing device and performing biological analyses immediately on the smartphone. We show two novel ways to exploit the capacities of the smartphone and discuss the challenges that we faced in the development of these applications. We first demonstrate a mobile system to identify …
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Phenomenological Approaches to the Analysis of High-Throughput Biological Experiments
… issues faced in the analysis of high-throughput experiments. In particular, novel methods for noise removal and for visualization are presented.
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Efficient Design Of Biological Experiments For Dose-Response Modeling In Nanomaterial Toxicology Studies
… procedure in nanotoxicology with simulation experiments. The proposed design method adopts suitable nonlinear dose response curve and non-constant variance model in experimental modeling, which more adequately represents the desirable properties of bioassay-experiment. A multiple objective …
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Estimation of Variation For High-throughput Molecular Biological Experiments With Small Sample Size
… can affect and even potentially mislead the biological conclusions. Meanwhile, the high-throughput experiments often involve a small number of samples due to the limitation of cost and time. In such cases, the stochastic information may dominate the outcome of an experiment because there may …
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Smooth Flow Control for On-Chip Pneumatic Micropumps
… systems can be controlled to accurately mimic biological conditions. Biological experiments can require flow profiles anywhere on the spectrum of smooth flow to highly pulsatile flow. A smooth flow profile can be modified with pumping delays to make the flow profile as pulsatile as desired. The …
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Extracting regulatory signals from DNA sequences using syntactic pattern discovery
… instances of regulatory motifs collected from biological literature, the algorithm showed, in 14 cases, a high sensitivity and specificity of 70% and 80%, respectively. TABS was shown to perform better than two other popular state-of-the-art motif-finding algorithms. In addition, its …
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Multi-view microscopy and multi-beam manipulation for high-resolution optical imaging
… microscopy and opens the third dimension for biological experiments like 3D cell cultures. Two instruments were built that provide high and isotropic resolution. In the Multi Imaging AxisMicroscope (MIAM) four objective lenses are used to both image the sample and to manipulate it with optical …
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Dissolution and Biokinetics of PCL in Denitrification Systems
… for wastewater denitrification. Laboratory experiments examined the effects of temperature, bead mass, solvent type, hydraulic retention time, and bead reuse on PCL dissolution and soluble chemical oxygen demand (SCOD) release. The dissolution behavior was represented using a modified …
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Integrating discrete stochastic models with single-cell and single-molecule experiments
Modern biological experiments can capture the behaviors of single biomolecules within single cells. Much like Robert Brown looking at pollen grains in water, experimentalists have noticed that individual cells that are genetically identical behave seemingly randomly in the way they carry out their …
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Post-transcriptional control of gene expression
… gene expression control by analyzing data from biological experiments. Most of the work following uses a common mathematical model framework based on Markov chain models to test hypotheses, predict system dynamics or elucidate network topology. Our work lies in the intersection between …
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Bayesian Interaction and Association Networks From Multiple Replicates of Sparse Time-Course Data
Biological experiments of proteins and genes often involve the collection of multiple replicates of sparse time-course data. From such time-course data, protein (or gene) interaction posterior probabilities are computed based on individual and multiple replicates. This is accomplished through …
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Computer-aided design for multilayer microfluidic chips
… as "lab-on-a-chip" systems that can automate biological experiments. As we are able to build more complex microfluidic chips with thousands of components, it becomes possible to build devices which can be programmatically changed to solve multiple problems. However, the current design …
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Passive wake detection using seal whisker-inspired sensing
This thesis is motivated by biological experiments, which display the harbor seal's ability to track the wake of an object several seconds after it swam by. In this work, I elucidate the basic fluid mechanisms that seals may employ to accomplish this detection. Key are the unique vortex-induced …
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A novel peptide QUB-2562, discovered from the skin secretion of the frog, Agalychnis annae
… QUB-2562. Then QUB-2562 was tested in several biological experiments and found to inhibit the growth of S. aureus (MIC = 2 µM; MBC = 2 µM), E. coli (MIC = 4 µM; MBC = 4 µM), and C. albicans (MIC = 8 µM; MBC = 16 µM). Meanwhile, its degrees of haemolysis at 2 and 16 µM were only 1% and 10%, …
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Design, Synthesis and Biological Properties of Estrogen Receptor Binding Breast Tumor Localizing Agents
… specific activity on a routine basis. Subsequent biological experiments showed that they were concentrated selectively in estrogen target tissues of the immature female rat and estrogen receptor containing DMBA induced mammary tumors in mature female rats by a mechanism presumably involving the …
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Microfluidic Platform for Vascularized Tissue Models
… to acutate the fluidic control elements. After a biological experiment the tissue culture devices can be disassembled, cleaned, and re-used, thus enabling cost-effective experimentation and prototyping. Each of the 4 layers of the tissue culture devices arc ma.de of thermoplastic polymers, and …
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Developing software for compressed imaging transcriptomics
Modern-day biological experimentation often necessitates a scale of data that is exponential with respect to the number of genes that are being measured, and this in turn leads to high latency and monetary cost during hypothesis testing. In addition to such practical constraints, some biological …
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Effects of Temperature on Anaerobic Lignin Degradation in Bioreactor Landfills
… were created in the laboratory. Several experiments were performed by the authors. Solubility of lignin based on temperature and time of thermal exposure were conducted. In addition, degradation studies were conducted based on biological treatment of lignin as well as a combination of …
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Computational discovery of gene modules, regulatory networks and expression programs
… mathematical methods are needed for extracting biological knowledge from high-dimensional, complex and noisy data sources. In this thesis, I develop and apply three novel computational approaches for this task. The common theme of these approaches is that they seek to discover meaningful groups …
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Assessing the Role of Clusters Derived from Large Sequence Similarity Networks for Gene Function Predictions
… the time and resource requirements necessary for biological experiments, computational predictions of gene functions can aid in reducing a large list of candidate genes to a few promising targets. Various computational solutions have been proposed and developed for gene function prediction. These …
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