Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Biological Clocks"”.
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Biological Clocks, Inflammation, and Multiorgan Damage In Sickle Cell Disease
<p>Sickle cell disease (SCD) is a dangerous condition caused by a genetic mutation on the human beta-globin gene that contributes to erythrocyte sickling, the hallmark of the disease. Previous metabolomics studies have confirmed that elevated sphingosine kinase 1 (SphK1) mediates …
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Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
<p>Biological systems are highly dynamic, yet our temporal resolution of such</p><p>dynamical processes is often limited or difficult to test in the laboratory. The 24-hour</p><p>circadian rhythm and the approximately 75-minute cell cycle of a budding yeast cell are</p><p>both examples of dynamical …
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The role of a circalunar clock in speciation
… Often, reproductive timing is controlled by biological clocks; endogenous molecular mechanisms that track environmental cycles. Given their prevalence, ecological relevance, and potential to isolate reproduction, biological clocks may play an important role in sympatric speciation. In my …
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Genetic noise in the cyanobacterial circadian oscillator
Clocks are generally considered as quintessential examples of accurate and precise devices. Biological clocks however, are continually subjected to intracellular and extracellular fluctuations that might reduce the fidelity of this periodic timer. One fundamental limitation that might set an upper …
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Dynamics of gene expression and signal transduction in single cells
… we explored the interaction between biological oscillators. Especially, we used an abstract model to describe and predict the synchronization of cell cycles by the circadian clock. Simultaneous measurement of both circadian dynamics and cell cycle dynamics in individual cyanobacteria …
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The Regulation of Segmentation Clock Period in Zebrafish
… are present at many different levels of biological organization. The cell cycle that directs the division of individual cells, the regular depolarization of neurons in the sinu-atrial node which underlies the regular beating of the heart, the circadian rhythms that govern the daily …
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A Mutational Analysis of the Period Locus of Drosophila Melanogaster
… is fundamentally involved in the generation of biological rhythms. Three classes of per mutations which alter circadian periodicity have been identified: per<sup>s</sup> mutants have circadian behavioral rhythms of 19h instead of 24h; per mutants have long period rhythms of 28h; and …
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Modulation of Nocturnin Phosphatase Activity through the Disordered Amino Terminus
The endogenous circadian clock controls the rhythmicity of behavioral and physiological processes and this is entrained by the daily fluctuations in light and dark. Nocturnin (Noct) is a rhythmically expressed gene regulated by the circadian clock that belongs to the CCR4 family of …