Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"Bioinorganic"”.
-
The crystal and molecular structures of some bioinorganic compounds
In this thesis are presented the results of X-ray structural studies of seven metal-containing crystalline compounds. In some cases, the ligands associated with the metals are themselves biologically active; in other cases, the compound as an entity, rather than any constituent, is of direct or …
-
Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin
… Individual chapter summaries follow. Chapter 1: Bioinorganic Chemistry of the Host Pathogen Interaction. Transition metal ions are required for all forms of life. During the course of infection, pathogenic microorganisms must acquire transition metals from the host. Three metals of interest from …
-
Two Methodologies in Pursuit of the Elucidation of Copper (II)—Centered Bioinorganic Chemistry
Copper is a widely distributed transition metal in the earth's crust and has been adopted in a variety of biological systems. In many ways the biochemical usefulness of copper stems from its positive redox potential. This positive redox potential allows copper to assist in the movement of …
-
Bioinorganic hydrocarbon oxidation : mechanistic and kinetic studies of the soluble methane monooxygenase from Methylococcus capsulates (bath)
Chapter 1. Principles of Small Molecule Activation by Metalloproteins as Exemplified by the Soluble Methane Monooxygenase -- Chapter 2. Small Molecule Binding to the Mixed-Valent Diiron Center of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) as Revealed by ENDOR …
-
A combined approach of electronic structure calculations and spectroscopy for elucidating reaction mechanisms in organic and bioinorganic systems
This thesis describes the use of density functional theory (DFT) to assist the interpretation of advanced spectroscopic techniques such as stopped flow Fourier transform infrared spectroscopy (FTIR), muon spin resonance (�SR), and nuclear inelastic scattering (NIS). These complementary techniques …
-
The creation and interpretation of an elemental database for Chinese traditional herbal remedies
… have been organic. Given the emerging area of bioinorganic chemistry/medicinal inorganic chemistry, it is now recognized that small molecule inorganic species play an equally important role in biology. In this regard, there has been very little research, if any, conducted into the search for …
-
Polyoxomolybdates with emergent properties
… relevance, e.g. for catalysis and for bioinorganic chemistry including even aspects of medicine regarding therapy as well as diagnosis. In this context, coordination chemistry studies under confined conditions seem to be of special importance. One unique class of the coordination …
-
New insight into the coordination and reactivity of hetero-substituted maltol and method development for complex mixture analysis of asphaltene.
… its hetero-substitutions have a wide variety of bioinorganic applications. However, the latest addition to this family of molecules, 3-hydroxy-2-methyl-4H-pyran-4-selenone (selenomaltol), had not previously had its metal complexes characterized. To remedy this, transition metal complexes were …
-
A developed metallomics method reveals the biochemical fate of Cd2+ and Hg species in erythrocyte lysate
… are urgently needed to gain new insight into the bioinorganic chemistry of non-essential metal species in the human body. To this end, a metallomics method was developed to probe the interaction of Cd2+, Hg2+, CH3Hg+ and thimerosal in the erythrocyte based on the direct analysis of erythrocyte …
-
Nitric oxide reactions of bio-Inspired zinc and cobalt complexes
Chapter 1. Bioinorganic Chemistry of Nitric Oxide and of Some of Its Targets The redox-active nature of nitric oxide (NO) regulates the chemistry and roles of NO in biology. The interactions of NO with nitric oxide synthases, metallothioneins, and cobalamin-containing enzymes are discussed. …
-
Investigation of zinc metalloneurochemistry with fluorescent sensors based on fluorescein platforms
… enzymes and proteins. Although the field of bioinorganic chemistry has not focused on the brain and central nervous system, metal ions are vital to many neurological functions and are implicated in several neurological disorders. In this chapter, I present a brief overview of the functions of …
-
Ameliorating the toxic side-effects of cisplatin by systematically modulating its metabolism in human plasma with chemoprotective agents
… of plasma allowed to gain more insight into the bioinorganic chemistry that unfolds in the absence of plasma proteins under physiologically similar conditions. Analysis of a PBS-buffer sample that was spiked with CP and STS by X-ray absorption spectroscopy revealed the presence of [Pt(S2O3)4]6- …
-
The in vitro selection and biochemical characterization of metalloDNAzymes
… and thus are an active area of research in bioinorganic chemistry. Additionally, DNAzymes have proven their ability to distinguish between various metal ions with as high as million-fold selectivities. Such selectivities between metal ions with similar charge, ionic radii, and other …
-
X-ray Spectroscopic Studies of Model Compounds With Relevance to Nickel Superoxide Dismutase, Nitrile Hydratase and Copper Related Neurodegenerative Disorders
… not crystallize. In this research a variety of bioinorganic systems were studied, each consisting of a transition metal compound that was non-crystallizable. The major goal in all projects was to determine the structure of the compounds using XAS along with many other spectroscopic techniques. …
-
Engineering novel tandem reactions using organometallic catalysts and metalloenzymes
Organometallic chemistry and bioinorganic chemistry are two prominent sub-disciplines of chemistry. Complexes of the transition metals are prominent components of both disciplines. On the one hand, considerable efforts in transition-metal catalysis have culminated in practical and efficient …
-
Bio-inspired iron and cobalt complexes featuring a secondary coordination sphere: ligand design, complexation, and modeling of enzymatic processes
The activation of small molecules is crucial to the function of biological systems’ metabolic processes, detoxification, and cellular signaling. Metallocofactors and protein scaffolds often work in conjunction to attract and bind the small molecules, stabilize reactive intermediates, and shuttle …
-
Oxyanion reduction in a non-heme iron system
… systems and the work of others in the area of bioinorganic chemistry creating biomimetic systems, our group designed a tripodal ligand platform featuring a secondary coordination sphere. The ligand is tautomerizable, which allows for versatility in both the primary and secondary coordination …
-
Metalloprotein engineering with unnatural amino acids: application in functional heme-copper oxidase and azurin
… amino acids greatly expands the toolbox of bioinorganic chemists. Several methods for unnatural amino acid incorporation have been developed, including cavity complementation, total synthesis, native chemical ligation, expressed protein ligation and amber suppression. They all have their own …
-
Development of Stimulus-Responsive Ligands for the Modulation of Copper and Iron Coordination
<p>The ability to manipulate the coordination chemistry of metal ions has significant ramifications for the study and treatment of metal-related health concerns, including iron overload, UV skin damage, and microbial infection among many other conditions. To address this concern, chelating agents …
Page 1 of 3