Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1466 for “"Bioinformatics."”.
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Shape Analysis in Bioinformatics
In this thesis we explore two main themes, both of which involve proteins. The first area of research focuses on the analyses of proteins displayed as spots on 2-dimensional planes. The second area of research focuses on a specific protein and how interactions with this protein can naturally …
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BioInformatics, Phylogenetics, and Aspartate Transcarbamoylase
… the necessity of understanding and using bioinformatics is demonstrated using the enzyme aspartate transcarbamoylase (ATCase) as the model enzyme. The first portion of this research focuses on the use of bioinformatics. A partial sequence of the pyrB gene found in Enterococcus faecalis was …
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BIOINFORMATICS INVESTIGATION OF RNA PSEUDOKNOTS
… In this dissertation, three large scale bioinformatics investigations were carried out on the roles of pseudoknots in the −1 PRF, as well as stop codon readthrough, recoding mechanisms in viral and human mRNAs. To meet the specific needs of the bioinformatics investigations, a new …
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Optimization Algorithms for Protein Bioinformatics
The last part of this dissertation centers on combinatorial library design, which is a promising protein engineering method. Despite the fact that several mathematical models have been proposed recently and shown great promise, little is known about their theoretic properties. We have discovered …
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Analysis of the bioinformatics industry
… information have created a new industry: The Bioinformatics Industry. This thesis analyzes technologies, applications market and competitors in this industry and explores potential changes to the business models that are being used today. The technology and market information indicates that …
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Building bioinformatics solutions for biomarker identification
… the design, implementation and application of bioinformatics systems to aid work in the field of biomarker discovery and diagnostic test development. The aim of the work was to develop a flexible data storage and analysis platform that would be capable of housing and working with data from a …
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Bioinformatics study of mammalian MRNA polydenylation
… issues of mammalian mRNA polyadenylation through bioinformatics approaches: (1) the extensive documentation of several key aspects of polyadenylation sites in humans and mice on a genomic level; (2) the evaluation of whether polyadenylation is an evolutionarily conserved cellular process between …
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Bioinformatics and database tools for glycans
… molecules and enzymes in the cell. Developing bioinformatics tools has been integral to advancing genomics and proteomics. While these tools have been well-developed to store and process sequence and structure information for proteins and DNA, they are very poorly developed for polysaccharides. …
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The BioLighthouse: Reusable Software Design for Bioinformatics
… are among the least reproducible in terms of bioinformatics. Software tools are often poorly documented, under-maintained, and commonly have arcane dependencies requiring significant time investment to configure them correctly. Microbiome studies are multidisciplinary efforts but communication …
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Bioinformatics framework for genotyping microarray data analysis
Functional genomics is a flourishing science enabled by recent technological breakthroughs in high-throughput instrumentation and microarray data analysis. Genotyping microarrays establish the genotypes of DNA sequences containing single nucleotide polymorphisms (SNPs), and can help biologists …
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Bioinformatics analyses of non-coding genomic elements
… these sequences. I will discuss studies using bioinformatics that leveraged these advances to characterize three types of non-coding sequences: endogenous retroviruses, microsatellite markers and transcription factor binding sites. I conducted the bioinformatics design, coding and analyses, …
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Bioinformatics and Mass Spectrometry for Neuropeptide Characterization
The methods employed for the discovery of neuropeptide genes and gene products in insect, echinoderms and chordates along with neuropeptide processing predictors present generalized and successful approaches for neuropeptide discovery in any organism.
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Global Optimization in Systems Biology and Bioinformatics
Identification of transcription factor binding motif and sites is a crucial effort to elucidate gene regulatory networks and its combinatorial problem is NP -hard. In this thesis, the problem is modeled as an integer linear program with weak assumptions on the binding pattern. A computationally …
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Bioinformatics-guided discovery and characterization of graspetides
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Optimization, random resampling, and modeling in bioinformatics
Quantitative phenotypes regulated by multiple genes are prevalent in nature and many diseases falls into this category. High-throughput sequencing and high-performance computing provides a basis to understand quantitative phenotypes. However, finding a statistical approach correctly model the …
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Integration and visualisation of data in bioinformatics
The most recent advances in laboratory techniques aimed at observing and measuring biological processes are characterised by their ability to generate large amounts of data. The more data we gather, the greater the chance of finding clues to understand the systems of life. This, however, is only …
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