Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Bioinert"”.
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Controlling the assembly of proteins and cells on SiO₂ surfaces
… systems. An effective strategy for achieving "bioinertness" for surfaces is their modification by poly(ethylene glycol)s (PEGs), which provides protein and cell repelling properties. This thesis centers on the development of ultrathin films of PEG on SiO₂ surfaces that 1) can resist the …
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Chain-end functionalization and modification of polymers using modular chemical reactions
… so that they are thermoresponsive, yet bioinert and biocompatible with adjustable cloud point values (as it is the case in the present thesis), the whole generated system becomes "smart" and potentially applicable in different branches. The applications which were considered in the …
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Novel processing of porous bioceramic structures
… orthopaedic applications since the 1960s. While bioinert materials such as zirconia have been used in load bearing applications due to their impressive mechanical properties, bioactive materials such as hydroxyapatite (HA) have been used to promote bone growth. Porous bioceramic structures have …
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Nanostructured apatites as orthopedic biomaterials
… in these implants have been largely limited to bioinert titanium-based alloys, as well as to polycrystalline alumina and zirconia ceramics. However, analysis of implants incorporating these traditional biomaterials indicated that most failures involved an unstable implant-tissue interface and/or …
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Antifouling and Antithrombogenic Ultrathin Surface Chemistry for Bioanalytical and Biomedical Applications
… contacting bodily fluids/tissues to be `bioinert'. A popular strategy to address this technological constraint consists in passivating substrate materials with an antifouling (respectively a biocompatible) organic coating. Yet, despite tremendous research activity and progress in recent …
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Nanotexturing for Biomedical Implants
… is an elastomeric polymer that is bioinert with mechanical properties similar to silicone rubber. The proposed work will consist of three layers, a substrate, electrospun PEO nanofiber, and a thin continuous coating of Arbomatrix film. When combined, the texturing from the PEO …
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Controlling Biofouling by Surface Engineering and Molecular Inhibition
… of methyl-terminated SAMs, surrounded by bioinert chiral polyol-terminated SAMs. Interestingly, SAMs presenting racemic mixture of enantiomeric alkanethiols were found to confine the adhered mammalian cells or biofilm within the micrometer-sized patterns longer than the SAMs presenting …
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Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine
… microparticles synthesized from non-fouling, bioinert poly(ethylene glycol) (PEG) and functionalized with biomolecule probes offer great promise in the development of high-performance, multiplexed bioassays. To extend this platform to applications in high-throughput analysis, particle design …
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New Mass Spectrometry Approaches to Investigate Proteins and Protein Interactions
… (AEX), which uses a low-pressure and bioinert workflow with ammonium acetate mobile phases, is used to enhance native MS by removing common contaminants that interfere with MS, separating protein variants based on their charge, and isolating proteins from complex mixtures. Those …
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PATTERNED BIOFILM FORMATION TO INVESTIGATE BACTERIA-SURFACE INTERACTIONS
… nonspecific binding of planktonic cells on the bioinert background. Interestingly, the mutants of <i>luxS</i> and <i>motB</i> exhibited major defects in interaction between cell clusters. The phenotype of the <i>luxS</i> mutant was successfully restored by both complementing the <i>luxS</i> gene …
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Silicone microspheres and disposable separation technology for gaseous analytes
… USP PDMS microspheres are shown to be highly bioinert, are found to be taken into cell cytosol, and show impressive drug loading capacities (as high as 36% by weight). Functional silicone microspheres are obtained by simply adding the appropriate dopant (e.g., fluorescent dye, colloidal Fe3O4, …
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Improving Bioactivity and the Anti-Bacterial Properties of Two-Solution Bone Cement Containing Cross-Linked Polymethylmethacrylate (PMMA) Nanospheres (η-TSBC)
<p>The high viscosity standard two-solution bone cements (STSBC) developed in our laboratory exhibits several advantages over other commercial powder-liquid cement formulations. However, the high monomer concentration, viscosity, and exothermal temperature are considered a major limitation to the …