Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Bioequivalence"”.
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Development and Bioavailability/Bioequivalence of a Fixed-Dose Combination Antiretroviral Reconstitutable Suspension Intended for Pediatrics
… designed to develop and assess bioavailability/ bioequivalence of age-appropriate fixed-dose combination granules of lamivudine/zidovudine/nevirapine as reconstitutable suspension for pediatrics for use in pediatric patients. The granules were developed via roller compaction process to improve …
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The disposition and bioequivalence of single-dose compounded, commercial, and intravenous levetiracetam in healthy dogs
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Topics in odds ratio estimation in the case-control studies and the bioequivalence testing in the crossover studies.
… eliminate the effect of several parameters on a bioequivalence testing procedure that plays an important role in the development of generic drugs. The current FDA criteria is not flexible with respect to highly variable drugs, and this characteristic has caused many good drugs to be rejected. …
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Using an In Vitro-In Vivo Correlation for the ‘Bioequivalence by Design’ Development of an Immediate Release Carbamazepine Product
… an alternative method, on the basis of errors in bioequivalence. The alternative method was based on the use of a physiologically based in vitro-in vivo correlation (PB-IVIVC) model that had been nested within a clinical trial simulation platform. The PB-IVIVC method provides a direct link from …
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Semiparametric Inference
… we develop a multivariate intersection-union bioequivalence test. The intersection- union test is uniform more powerful compare with other common used test for multivariate bioequivalence. Fourthly, we extend the multivariate bioequivalence test to functional data, which can also be considered …
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Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Fentanyl in Dogs
Results of the bioequivalence analysis indicated the model was not equivalent. The model was examined using time averaged inputs of tissue blood flows and using stepped changes in tissue blood flow representing measured changes in individual experimental subjects. Analysis of partial areas under …
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Statistical aspects of bioavailability
… is proposed as a tool for assessing bioequivalence. A new measure of bioequivalence, the Index of Concordance, is proposed. This index can be computed with equal ease for univariate or multivariate data using the bootstrap (Chapter 5). The bootstrap idea of resampling the data can …
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Relative Bio-Equivalence of Salbutamol MDIs Without and With the Attached Spacers. Development and validation of novel HPLC methods for the determination of salbutamol (and terbutaline) in urine excreted post-inhalation for bioequivalence and pharmacokinetic studies of Salbutamol MDIs
… dose (FPD) and total delivered dose (TDD). Bioequivalence studies were conducted in humans using the urinary pharmacokinetic method. Post-inhalation urinary excretion of salbutamol in the first 0.5 hour (lung deposition, USAL0.5) and over 24 hours (total systemic bioavailability, USAL24) …
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Early vascular access in the critical adult : intraosseous and intravenous approaches.
… thematically, studying ease of access and bioequivalence. Findings show that IO is as effective as PIV during resuscitation however it is temporary. Studies into how long the IO cannula can be left in situ are limited, along with research on the use of adrenaline and the 11 complications of …
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The development and evaluation of a hydrogel drug delivery system for dithranol.
… indicated that there was an approximate bioequivalence between the hydrogel and 0.1% Dithrocream. This was confirmed with 6 psoriatic patients which also showed that both are more effective than occlusion alone or blank hydrogel. From the data obtained, some suggestions about the possible …
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IN VITRO IN VIVO METHODS AND PHARMACOKINETIC MODELS FOR SUBCUTANEOUSLY ADMINISTERED PEPTIDE DRUG PRODUCTS
… Program involves the use of clinical data from a bioequivalence (BE) study of Iplex™ [(IGF-I (Insulin like growth factor-I)/IGFBP-3 (Insulin like growth factor binding protein-3)], administered subcutaneously, that was conducted at the Center for Drug Studies (CDS), VCU School of Pharmacy in the …
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Evaluation of adherence to antiretroviral therapy using efarivenz as a marker
… and interpretation of bioavailability, bioequivalence and pharmacokinetic data. Even with patient adherence, various intra-individual factors have an influence on the expression and function of the genes responsible for the transport (MDR1) and metabolism (CYP2B6) of Efavirenz (EFV). …
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Bioequivalência tópica de produtos contendo metronidazol através da dermatofarmacocinética (DPK)
A bioequivalência de três formulações de metronidazol (MTZ) 0,75% sendo uma delas disponível no Brasil, Rozex® (Galderma, Brasil, produto de referência) e duas formulações geleificadas (Teste 01 e Teste 02) desenvolvidas em nosso laboratório contendo os mesmos excipientes do produto referência …
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ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΙΣΟΔΥΝΑΜΙΑΣ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΚΥΚΛΟΦΟΡΟΥΝ ΣΤΗΝ ΕΛΛΑΔΑ
THE PHARMACOKINETIC BEHAVIOUR OF ORALLY ADMINISTERED PRODUCTS CONTAINING ACETYLSALICYLIC ACID WAS STUDIED IN HUMAN VOLUNTEERS. THE ADMINISTERED DRUGS, EACH OF WHICH CONTAINED 500 MG OF THE ACTIVE SUBSTANCE WERE THE FOLLOWING ASPIRIN R, COLFORT R, SALOSPIR R, NASPIN K, KALACALINE R AND CESPIRE R. …